Background: Psoriasis is a chronic, relapsing, immune-mediated inflammatory skin disease. Pro-inflammatory cytokines involved in its pathogenesis not only drive keratinocyte hyperproliferation but are also associated with systemic conditions such as metabolic syndrome and hyperuricemia, increasing the risk of multi-organ complications. In Mongolia, studies evaluating laboratory parameters among patients with psoriasis remain limited, which underscores the need for the present study. Aim: To assess selected laboratory parameters in patients with psoriasis. Materials and Methods: A retrospective study was conducted using medical records of 678 patients hospitalized with a diagnosis of psoriasis (ICD-10: L40) at the National Dermatology Center. Relevant laboratory data were extracted and analyzed. Results: Among the 678 patients, 397 (58.5%) were male and 281 (41.4%) were female, with a mean age of 42.6 ± 15.6 years. According to ICD-10 classification, 359 (52.9%) were diagnosed with psoriasis vulgaris (L40.0). Disease severity was significantly higher in males (p = 0.006). The mean laboratory values were as follows: total cholesterol 5.35 ± 1.72 mmol/L, triglycerides 2.02 ± 7.83 mmol/L, glucose 5.34 ± 4.46 mmol/L, AST 32.27 ± 36.23 U/L, ALT 35.39 ± 38.52 U/L, and uric acid 320.39 ± 106.67 µmol/L. Significant sex-based differences were observed in ALT, AST (p < 0.0005, p < 0.0001), and uric acid levels (p < 0.0001). A weak positive correlation was identified between uric acid levels and body mass index (r = 0.16, p < 0.05). Conclusion Chronic systemic inflammation in psoriasis is associated with an increased risk of metabolic syndrome, dyslipidemia, and hyperuricemia. Regular monitoring of laboratory parameters is a simple yet essential approach for early detection and prevention of comorbidities, ultimately contributing to improved patient outcomes and quality of life