Objective: To determine whether microtubule-associated protein 2 (MAP2) and microtubule-associated protein 1B (MAP1B) could be prognostic biomarkers for patients with pancreatic neuroendocrine tumors (PNETs). Methods:With immunohisto-chemical staining, the expressions of MAP2 and MAP1B were examined in 193 and 120 primary tumors and peritumoral tissues, re-spectively. Then, the relationship between the expression of each protein and clinicopathological characteristics, including prognosis was analyzed. Results:MAP2 and MAP1B were expressed in 88 of 193 (45.6%) and 77 of 120 (64.2%) tumors, respectively. The expres-sion of MAP2 was significantly associated with the favorable overall survival of patients with PNETs (P=0.012). Moreover, MAP2 expres-sion was associated with the improved overall survival in a subset of patients with stageⅡand stageⅢtumors (P=0.017). The MAP1B expression did not correlate with other clinicopathological features and prognosis. Conclusion:MAP2 could be a novel, independent prognostcbiomarker for PNETs.

This paper introduced the model of clinical pharmacists involving in pharmacy administration in Southwest Hospital.It features the following :1 .Establishment of the chief resident pharmacists mechanism , with clinical pharmacists involving in clinical drug treatment , therapy consultations and hospital‐wide consultations ;2 .Rational drug use quality control ,to supervise normative drug use of clinicians using the driver′s license management system for drug use;3 .Establishment of effective communication channels between physicians and pharmacists ,for mutual learning and supervision .Such model has helped clinical pharmacists to accumulate experiences in drug therapy ,and encouraged rational drug use .

A 74-Year-old female patient with coronarY arterY disease underwent primarY percutaneous coronarY intervention and received iodixanol 220 ml during the operation. Before the intervention,the patient's white blood cell(WBC)count was 8. 6 × 109/L,neutrophil(n)count was 4. 2 × 109/L,eosinophil(E)count was 0. 36 × 109/L,and serum creatinine level was 122 μmol/L. On daY 4 postoperation,the patient developed erYthema of bacK and right upper limb,swelling of hands( especiallY the right hand). she was given prednisone 5 mg and loratadine 10 mg once dailY. On daY 5 postoperation, the patient developed pruritus and pain on generalized sKin,erYthema of abdomen and thighs,and sKin chapping with exudation of right hand. The patient's WBC count was 12. 7 × 109/L,n count was 8. 6 × 109/L,and E count was 0. 73 × 109/L. DelaYed exfoliative dermatitis induced bY iodixanol was considered. Dexamethasone 10 mg once dailY was given bY an Iv infusion and calamine lotion was externallY applied on the sKin surface. After 4 daYs of treatments,the pruritus was improved and the patient developed excessivelY Keratinization with pachulosis and crusting in the right hand and arm. Dexamethasone was stopped. After 14 daYs of treatments,the patient's WBC count was 10. 6 × 109/L,n count was 6. 6 × 109/L,and E count was 0. 37 × 109/L;her sKin returned to normal. Then,prednisone and loratadinetreatments were stopped.

A 74-Year-old female patient with coronarY arterY disease underwent primarY percutaneous coronarY intervention and received iodixanol 220 ml during the operation. Before the intervention,the patient's white blood cell(WBC)count was 8. 6 × 109/L,neutrophil(n)count was 4. 2 × 109/L,eosinophil(E)count was 0. 36 × 109/L,and serum creatinine level was 122 μmol/L. On daY 4 postoperation,the patient developed erYthema of bacK and right upper limb,swelling of hands( especiallY the right hand). she was given prednisone 5 mg and loratadine 10 mg once dailY. On daY 5 postoperation, the patient developed pruritus and pain on generalized sKin,erYthema of abdomen and thighs,and sKin chapping with exudation of right hand. The patient's WBC count was 12. 7 × 109/L,n count was 8. 6 × 109/L,and E count was 0. 73 × 109/L. DelaYed exfoliative dermatitis induced bY iodixanol was considered. Dexamethasone 10 mg once dailY was given bY an Iv infusion and calamine lotion was externallY applied on the sKin surface. After 4 daYs of treatments,the pruritus was improved and the patient developed excessivelY Keratinization with pachulosis and crusting in the right hand and arm. Dexamethasone was stopped. After 14 daYs of treatments,the patient's WBC count was 10. 6 × 109/L,n count was 6. 6 × 109/L,and E count was 0. 37 × 109/L;her sKin returned to normal. Then,prednisone and loratadinetreatments were stopped.