1.Revisiting the Etiology of Cocaine-Related Ischemic Strokes: An Observational Cohort
Olivia A. KOZEL ; Sachin A. KOTHARI ; Harsh DESAI ; Anit BEHERA ; Rami Z. MORSI ; Archit B. BASKARAN ; Neha SEHGAL ; Shyam PRABHAKARAN ; Tareq KASS-HOUT ; James E. SIEGLER ; Scott J. MENDELSON
Journal of Stroke 2025;27(2):253-256
2.Papillary muscles: morphological differences and their clinical correlations
Neha XALXO ; Simarpreet KAUR ; Mohit CHAUHAN ; Ekta SHARMA ; Laishram SOPHIA ; Sneh AGARWAL ; Pooja JAIN
Anatomy & Cell Biology 2025;58(1):44-53
The complex architecture of the papillary muscles (PMs) of the ventricles plays a crucial role in cardiac function and pathology. This comparative study aimed to examine the differences in PMs morphology between the right and left ventricles, focusing on their number, location, and shape. A total of 38 grossly normal hearts from donated bodies were dissected, and the number, location, and shape of PMs in both ventricles were observed. In this study, the left ventricle predominantly exhibited a single PM with 71.05% on the sternocostal surface and 57.89% on the diaphragmatic surface.The right ventricle showed a higher prevalence of single PM, at 89.47% on the sternocostal surface and 63.16% on the diaphragmatic surface. Broad-based shape of the PM emerged as the predominant variant, constituting 55.26% and 44.73% on the sternocostal and diaphragmatic surfaces of the left ventricle, respectively. In contrast, conical-shaped PM predominated in the right ventricle. Unique findings included “H” and “b” shaped muscles, conjoint PMs were observed exclusively in the left ventricle, and small papillary projections with direct tendinous cord attachment in the right ventricle. A distinct webbed shaped configuration of PM was exclusively observed in the right ventricle in only one specimen. No significant difference (P=0.84) was noted in muscle bellies between ventricular surfaces. This study emphasizes the complexity and variability in PM morphology, highlighting the importance of a thorough understanding of these structures for cardiothoracic surgeons, radiologists, and cardiologists to enhance interventional techniques.
3.Papillary muscles: morphological differences and their clinical correlations
Neha XALXO ; Simarpreet KAUR ; Mohit CHAUHAN ; Ekta SHARMA ; Laishram SOPHIA ; Sneh AGARWAL ; Pooja JAIN
Anatomy & Cell Biology 2025;58(1):44-53
The complex architecture of the papillary muscles (PMs) of the ventricles plays a crucial role in cardiac function and pathology. This comparative study aimed to examine the differences in PMs morphology between the right and left ventricles, focusing on their number, location, and shape. A total of 38 grossly normal hearts from donated bodies were dissected, and the number, location, and shape of PMs in both ventricles were observed. In this study, the left ventricle predominantly exhibited a single PM with 71.05% on the sternocostal surface and 57.89% on the diaphragmatic surface.The right ventricle showed a higher prevalence of single PM, at 89.47% on the sternocostal surface and 63.16% on the diaphragmatic surface. Broad-based shape of the PM emerged as the predominant variant, constituting 55.26% and 44.73% on the sternocostal and diaphragmatic surfaces of the left ventricle, respectively. In contrast, conical-shaped PM predominated in the right ventricle. Unique findings included “H” and “b” shaped muscles, conjoint PMs were observed exclusively in the left ventricle, and small papillary projections with direct tendinous cord attachment in the right ventricle. A distinct webbed shaped configuration of PM was exclusively observed in the right ventricle in only one specimen. No significant difference (P=0.84) was noted in muscle bellies between ventricular surfaces. This study emphasizes the complexity and variability in PM morphology, highlighting the importance of a thorough understanding of these structures for cardiothoracic surgeons, radiologists, and cardiologists to enhance interventional techniques.
4.Papillary muscles: morphological differences and their clinical correlations
Neha XALXO ; Simarpreet KAUR ; Mohit CHAUHAN ; Ekta SHARMA ; Laishram SOPHIA ; Sneh AGARWAL ; Pooja JAIN
Anatomy & Cell Biology 2025;58(1):44-53
The complex architecture of the papillary muscles (PMs) of the ventricles plays a crucial role in cardiac function and pathology. This comparative study aimed to examine the differences in PMs morphology between the right and left ventricles, focusing on their number, location, and shape. A total of 38 grossly normal hearts from donated bodies were dissected, and the number, location, and shape of PMs in both ventricles were observed. In this study, the left ventricle predominantly exhibited a single PM with 71.05% on the sternocostal surface and 57.89% on the diaphragmatic surface.The right ventricle showed a higher prevalence of single PM, at 89.47% on the sternocostal surface and 63.16% on the diaphragmatic surface. Broad-based shape of the PM emerged as the predominant variant, constituting 55.26% and 44.73% on the sternocostal and diaphragmatic surfaces of the left ventricle, respectively. In contrast, conical-shaped PM predominated in the right ventricle. Unique findings included “H” and “b” shaped muscles, conjoint PMs were observed exclusively in the left ventricle, and small papillary projections with direct tendinous cord attachment in the right ventricle. A distinct webbed shaped configuration of PM was exclusively observed in the right ventricle in only one specimen. No significant difference (P=0.84) was noted in muscle bellies between ventricular surfaces. This study emphasizes the complexity and variability in PM morphology, highlighting the importance of a thorough understanding of these structures for cardiothoracic surgeons, radiologists, and cardiologists to enhance interventional techniques.
5.Revisiting the Etiology of Cocaine-Related Ischemic Strokes: An Observational Cohort
Olivia A. KOZEL ; Sachin A. KOTHARI ; Harsh DESAI ; Anit BEHERA ; Rami Z. MORSI ; Archit B. BASKARAN ; Neha SEHGAL ; Shyam PRABHAKARAN ; Tareq KASS-HOUT ; James E. SIEGLER ; Scott J. MENDELSON
Journal of Stroke 2025;27(2):253-256
6.Papillary muscles: morphological differences and their clinical correlations
Neha XALXO ; Simarpreet KAUR ; Mohit CHAUHAN ; Ekta SHARMA ; Laishram SOPHIA ; Sneh AGARWAL ; Pooja JAIN
Anatomy & Cell Biology 2025;58(1):44-53
The complex architecture of the papillary muscles (PMs) of the ventricles plays a crucial role in cardiac function and pathology. This comparative study aimed to examine the differences in PMs morphology between the right and left ventricles, focusing on their number, location, and shape. A total of 38 grossly normal hearts from donated bodies were dissected, and the number, location, and shape of PMs in both ventricles were observed. In this study, the left ventricle predominantly exhibited a single PM with 71.05% on the sternocostal surface and 57.89% on the diaphragmatic surface.The right ventricle showed a higher prevalence of single PM, at 89.47% on the sternocostal surface and 63.16% on the diaphragmatic surface. Broad-based shape of the PM emerged as the predominant variant, constituting 55.26% and 44.73% on the sternocostal and diaphragmatic surfaces of the left ventricle, respectively. In contrast, conical-shaped PM predominated in the right ventricle. Unique findings included “H” and “b” shaped muscles, conjoint PMs were observed exclusively in the left ventricle, and small papillary projections with direct tendinous cord attachment in the right ventricle. A distinct webbed shaped configuration of PM was exclusively observed in the right ventricle in only one specimen. No significant difference (P=0.84) was noted in muscle bellies between ventricular surfaces. This study emphasizes the complexity and variability in PM morphology, highlighting the importance of a thorough understanding of these structures for cardiothoracic surgeons, radiologists, and cardiologists to enhance interventional techniques.
7.Papillary muscles: morphological differences and their clinical correlations
Neha XALXO ; Simarpreet KAUR ; Mohit CHAUHAN ; Ekta SHARMA ; Laishram SOPHIA ; Sneh AGARWAL ; Pooja JAIN
Anatomy & Cell Biology 2025;58(1):44-53
The complex architecture of the papillary muscles (PMs) of the ventricles plays a crucial role in cardiac function and pathology. This comparative study aimed to examine the differences in PMs morphology between the right and left ventricles, focusing on their number, location, and shape. A total of 38 grossly normal hearts from donated bodies were dissected, and the number, location, and shape of PMs in both ventricles were observed. In this study, the left ventricle predominantly exhibited a single PM with 71.05% on the sternocostal surface and 57.89% on the diaphragmatic surface.The right ventricle showed a higher prevalence of single PM, at 89.47% on the sternocostal surface and 63.16% on the diaphragmatic surface. Broad-based shape of the PM emerged as the predominant variant, constituting 55.26% and 44.73% on the sternocostal and diaphragmatic surfaces of the left ventricle, respectively. In contrast, conical-shaped PM predominated in the right ventricle. Unique findings included “H” and “b” shaped muscles, conjoint PMs were observed exclusively in the left ventricle, and small papillary projections with direct tendinous cord attachment in the right ventricle. A distinct webbed shaped configuration of PM was exclusively observed in the right ventricle in only one specimen. No significant difference (P=0.84) was noted in muscle bellies between ventricular surfaces. This study emphasizes the complexity and variability in PM morphology, highlighting the importance of a thorough understanding of these structures for cardiothoracic surgeons, radiologists, and cardiologists to enhance interventional techniques.
8.Revisiting the Etiology of Cocaine-Related Ischemic Strokes: An Observational Cohort
Olivia A. KOZEL ; Sachin A. KOTHARI ; Harsh DESAI ; Anit BEHERA ; Rami Z. MORSI ; Archit B. BASKARAN ; Neha SEHGAL ; Shyam PRABHAKARAN ; Tareq KASS-HOUT ; James E. SIEGLER ; Scott J. MENDELSON
Journal of Stroke 2025;27(2):253-256
9.Inpatient Outcomes of Cerebral Venous Thrombosis in Patients With Malignancy Throughout the United States
Sima VAZQEZ ; Ankita DAS ; Eris SPIROLLARI ; Paige BRABANT ; Bridget NOLAN ; Kevin CLARE ; Jose F. DOMINGUEZ ; Neha DANGAYACH ; Krishna AMULURU ; Shadi YAGHI ; Ji CHONG ; Chaitanya MEDICHERLA ; Halla NUOAMAN ; Neisha PATEL ; Stephan A. MAYER ; Chirag D. GANDHI ; Fawaz AL-MUFTI
Journal of Stroke 2024;26(3):425-433
Background:
and Purpose Cerebral venous thrombosis (CVT) is associated with a high degree of morbidity and mortality. Our objective is to elucidate characteristics, treatments, and outcomes of patients with cancer and CVT (CA-CVT).
Methods:
The 2016–2019 National Inpatient Sample (NIS) database was queried for patients with a primary diagnosis of CVT. Patients with a currently active diagnosis of malignancy (CA-CVT) were then identified. Demographics and comorbidities were compared between CA-CVT and CVT patients. Subgroup analyses explored patients with hematopoietic cancer and non-hematopoietic cancers. Stroke severity and treatment were explored. Inpatient outcomes studied were discharge disposition, length of stay, and mortality.
Results:
Between 2016 and 2019, 6,140 patients had a primary diagnosis code of CVT, and 370 (6.0%) patients had a coexisting malignancy. The most common malignancy was hematopoietic (n=195, 52.7%), followed by central nervous system (n=40, 10.8%), respiratory (n=40, 10.8%), and breast (n=40, 10.8%). These patients tended to be older than non-CA-CVT and were more likely to have coexisting comorbidities. CA-CVT patients had higher severity scores on the International Study of Cerebral Vein and Dural Sinus Thrombosis Risk Score (ISCVT-RS) and increased complications. In a propensity-score matched cohort, there were no differences in inpatient outcomes.
Conclusion
Malignancy occurs in 6% of patients presenting with CVT and should be considered a potential comorbidity in instances where clear causes of hypercoagulabilty have not been identified. Malignancy was linked to higher mortality rates. Nonetheless, after adjusting for the severity of CVT, the outcomes for inpatients with cancer-associated CVT were comparable to those without cancer, indicating that the increased mortality associated with malignancy is probably due to more severe CVT conditions.
10.Caregiver acceptability of a novel social needs program in a pediatric emergency department during the coronavirus disease 2019 pandemic: a qualitative study
Neha CHOHAN ; Bianca NFONOYIM ; Lauren VONHOLTZ ; Ashlee MURRAY
Pediatric Emergency Medicine Journal 2023;10(1):11-16
Purpose:
The coronavirus disease 2019 pandemic has heightened social needs of many families, with the demand for resources, such as food, housing assistance, utilities, childcare, and mental health, rising throughout the United States. These needs were recognized by the Division of Emergency Medicine and Department of Social Work at Children’s Hospital of Philadelphia in April 2020, resulting in the creation of “Family Connects,” a program that mobilizes a multidisciplinary workforce to meet social needs in the emergency department (ED). We aimed to understand experiences of families who engaged with and received information about the resources through the program.
Methods:
We conducted a qualitative, semi-structured, telephone interview study with a purposive convenience sample of adult participants who visited our ED as legal guardians of their ill or injured children from December 2020 through February 2021 and were contacted by a Family Connects representative. Participants were recruited via phone calls and asked questions regarding their perspectives of the program logistics, the telephone interaction, and the information provided about resources. The interviews were recorded, transcribed verbatim, and de-identified. Transcripts were coded by 2 independent coders and analyzed for themes by 2 reviewers and the principal investigator.
Results:
Twenty-eight interviews were completed with 18 families who received information about resources, and 10 who did not. Four major themes arose: overall positive experience with the program, mixed preferences surrounding modes of communication and information distribution, poor timing of phone calls during ED visit, and numerous barriers to accessing resources. Participants provided suggestions for improvement, including sending a text-alert prior to receiving the phone calls and post-ED follow-ups to help families access resources.
Conclusion
Families expressed an openness to being asked about social needs, though barriers including difficulty accessing resources and suboptimal phone call timing must be addressed to improve program delivery and effectiveness.

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