The aim of study was to evaluate the antioxidant action of the medicinal herb ZygophyllumPotaninii Maxim on rat liver hepatitis induced by carbone tetrachloride (CCl4), and the content of selenium in this herb. The results showed that the content of selenium in the surface part of ZygophyllumPotaninii Maxim was 0.34 ppm, while in the infusion it was 0.14µg/ml and 0.12µg/mlin the extract. ZygophyllumPotaninii Maxim water extract at the dose of 200mg/kg. CCl4 was diluted with heliante oil (1 /4 v/v) for experimental groups and these treatments were administrated three times in a week for a period of 12 weeks. Therefore, the aim of the present study is to investigate the possible protective role of selenium on the experimental liver cirrhosis and some enzyme activities in blood plasma from rats. Based upon these results, selenium may play in important role in the preventive indication of hepatic cellular injury inducted by carbon tetrachloride.