1.Changes in rat behavior, lung, and hippocampal effects due to vaping exposure
Oyungerel S ; Tumenbayar B ; Javzandulam B ; Chimegsaikhan S ; Khulan B ; Altantsetseg B ; Mandakh-erdene B ; Munkhsoyol E
Mongolian Journal of Health Sciences 2025;87(3):141-146
Background:
Nicotine-containing vaporized liquids—composed of
propylene glycol, glycerin, water, flavorings, and the thickening agent
vitamin E acetate—have been implicated in the development of EVALI.
Under conditions of low liquid levels and overheating, these substances
release toxic carbonyl compounds (e.g., formaldehyde, acetaldehyde,
acrolein). In a 2019 national survey, 3.5% of adolescents aged 13–15
reported cigarette use, and 10% used e-cigarettes.
Aim:
To study the changes in the behavior, lung, and hippocampal
structures of rats due to the effects of electronic cigarettes and their
vapor.
Materials and Methods:
In this study, nineteen 14-day-old SHR rats
were exposed to 1 g/mg/day of nicotine and dry hit vapor (control, nicotine
and dry hit groups) for four weeks. Behavioral assessments (Open
Field Test, Elevated Plus Maze, Conditioned Place Preference), bronchoalveolar
lavage (BAL), and histological analysis of lung and hippocampal
tissue were conducted.
Results:
The dry hit vapor group showed significantly reduced body
weight (p=0.034), increased anxiety (p=0.006, p=0.025), and avoidance
of the smoky chamber. BAL revealed elevated total cells, neutrophils,
and macrophages (p=0.01, p=0.04) in both nicotine and dry hit groups.
Lung tissue exhibited alveolar septal thickening, inflammation, and emphysema-
like changes. Extensive neuronal death was observed in the
hippocampus.
Conclusion
Anxiety-like behavior was observed in both the burn and
control groups. Analysis of BAL in the dry hit group revealed inflammation
predominantly characterized by macrophage infiltration. Histological
examination of lung tissue from both experimental groups
demonstrated a reduction in the number of alveoli, accompanied by
acute inflammation and thickening of the interalveolar septa. In the hippocampal
region, neuronal loss and a reduction in neuronal density
were also observed.
2.The assessment of physical development of children
Otgon G ; Tsetsegdolgor D ; Sarangerel D ; Osokhbayar Ch ; Munkhsoyol E ; Burenjargal B ; Bat-Erdene Ch ; Jadamba M ; Gundegmaa L ; Achsailkhan G ; Batkhishig B
Diagnosis 2025;113(2):89-93
Introduction:
Factors such as social and economic conditions, technological development, modern urbanization, lifestyle, physical activity, nutrition, and air pollution affect physical growth and development. Aim: To study the physical development of Mongolian children.
Objectives:
1. To measure the physical indices (weight, height) of children aged 6-17 years old with some influencing factors.
Material and method:
Using a random sampling method, children's body height and weight were examined at a particular point in time using widely accepted methods. Statistical analysis was performed using the "SPSS ver.25" program.
Result:
The growth of children's height and weight is progressing according to general patterns of age and gender. Girls grow rapidly between the ages of 10-13 and stabilize after wards, while boys a sharp growth spurt between the ages of 13-17, with the average height of 17-year-old boys being 171.44 cm and 160.25 cm for girls, which is slightly higher than previous studies (Otgon G, 2006, Munkhzaya M, 2020). The trend of weight growth is more prominent in boys. However, compared to international standards (Russia, WHO, CDC), our children's height and weight are lower. The statistics show that parental education, income, exercise, and living environment positively influence growth and development, whereas excessive television watching and air pollution negatively affect it (p< 0.05).
Conclusion
1. Children's growth is normal, but observed increase of the body weight of boys. Having healthy and well educated parents, as well as engaging in physical activity positively influences children's height. A lack of physical activity negatively affects height and increases weight. Mongolian children are shorter and lighter compared to foreign children (from Russia and America - CDC).
Result Analysis
Print
Save
E-mail