1.Outcomes of measures to prevent dose selection errors (2023-2024)
Nomin-Erdene Ts ; Tserennyam D ; Delgermaa Ts ; Orgilmaa Ts ; Mungunchimeg M ; Khulan M ; Khulan A ; Nina M ; Erdenetuya M
Mongolian Journal of Health Sciences 2025;87(3):154-160
Background:
A drug related problem is defined by the Pharmaceutical Care
Network Europe Association as an an event or circumstance involving drug
therapy that actually or potentially interferes with desired health outcomes.
One critical aspect of preventing such errors is proper dose adjustment, which
plays a vital role in the diagnosis and treatment of disease. For instance, adjusting
the dose of warfarin based on the patient’s INR level is essential. In
a 1995 study conducted in England, clinical pharmacists recommended target
doses of angiotensin-converting enzyme (ACE) inhibitors for patients with
chronic heart failure. As a result, patients experienced a significant reduction
in pulmonary and peripheral edema, along with improved exercise test outcomes.
At the Mongolian-Japanese Hospital of the Mongolian Medical University
of Science and Technology, it is important to analyze dosage-related
issues identified by clinical pharmacists and inform healthcare professionals
about common dosage selection errors and associated risks.
Aim:
We analyzed issues related to medication dosage.
Materials and Methods:
A retrospective study was conducted to examine
problem related to dosage detected through prescription monitoring at the
Mongolian Japanese Hospital of the Mongolian National University of Health
Sciences from 2023 to 2024.
Results:
Out of a total of 2340 drug-related problem identified across five
inpatient wards during this period, 581 (100%) were related to dosage. Clinical
pharmacists performed prescription review on approximately 67% of all
inpatients, which was consistent between years. However, medication-related
problems tended to decrease from 41.1% (n=1499) in 2023 to 22.3% (n=841)
in 2024 (p=0.05). The majority of dose-related problems, 75.6% (n=440), were
overdoses. Medication-related problems were most common in the surgical
department, with 59.5% (n=346) (p=0.001). The most frequent dosage-related
errors involved exceeding the daily dose of diclofenac, administering higher-
than-recommended doses of ceftriaxone, failing to adjust cefotaxime for
renal function, and using inappropriate doses of metronidazole in patients with
impaired liver function. The leading cause of these errors was failure to adhere
to guideline-recommended dosing, which accounted for 71.3% (n=415)
of cases (p=0.001). When dosage-related recommendations were provided to
physicians before of treatment, acceptance rates increased by 14% (p=0.001).
These interventions resulted in an estimated cost saving of 1.267.219₮ and a
reduction of 363 injections.
Conclusion
Therefore, clinical pharmacist-led prescription review can help
reduce the risk of dosage errors, lower associated healthcare costs, and alleviate
the burden on medical staff.
2.Knowledge, attitudes, and practices regarding modifiable cardiovascular risk factors and healthy lifestyle among adults
Punsaldulam Ts ; Mungunchimeg D ; Tumur-Ochir Ts ; Narandelger M ; Adiya N ; Batnaran D ; Mungun-Ulzii Kh ; Suvd B
Mongolian Medical Sciences 2025;213(3):20-31
Introduction :
Noncommunicable diseases (NCDs) caused at least 43 million deaths in 2021, equivalent
to 75% of non-pandemic-related deaths globally. Cardiovascular diseases account for most
NCD deaths, or at least 19 million deaths in 2021, followed by cancers (10 million), chronic
respiratory diseases (4 million), and diabetes (over 2 million including kidney disease deaths
caused by diabetes). These four groups of diseases account for 80% of all premature NCD
deaths. According to the Fourth National Survey on the Prevalence of Noncommunicable
Diseases, Injuries, and Their Risk Factors: 14.0% of adults aged 15–69 have experienced
a heart attack or stroke, 11.0% report taking aspirin to prevent or manage cardiovascular
disease (CVD), 2.2% use lipid-lowering medications (statins) for CVD prevention or treatment,
among adults aged 40–69, 19.3% are at high risk of developing CVD within the next 10 years.
These findings underscore the urgent need to strengthen cardiovascular disease prevention
efforts and improve the management of key risk factors in Mongolia.
Goal:
To determine the population’s knowledge, attitudes, and practices related to cardiovascular
disease risk factors and healthy lifestyle behaviors.
Materials and Methods:
This descriptive cross-sectional study included 2,532 participants aged 18–69 years from all
21 provinces of Mongolia and Ulaanbaatar city, as part of the “Cardiology, Cardiac Surgery,
and Telemedicine in Mongolia” (MON/007) Project. Data were collected using a structured
questionnaire comprising six sub-sections, designed to assess knowledge, attitudes, and practices related to 10 modifiable cardiovascular risk factors. Ethical approval was obtained
prior to the study, and data were analyzed using SPSS version 23.
Results:
Thirty-three percent of study participants reported having no knowledge of cardiovascular
disease, indicating that roughly one in three adults consider themselves to have little or no
understanding of cardiovascular health. In the study, 53.0% of participants reported being
unaware of the symptoms of a heart attack, while 42.0% did not recognize the symptoms of a
stroke. Among participants who could identify these symptoms, 68.0% indicated dizziness as
a sign of hypertension, 65.0% reported headache, and 58.0% noted blurred vision. Among
the respondents, 31.0% knew that the normal arterial blood pressure for an adult is 120/80
mmHg, 57.0% were aware that an adult should sleep 7–8 hours per day, 13.0% knew about
body mass index (BMI), 30.0% were aware of fasting blood glucose levels, and 44.0%
recognized that adults should engage in 30 minutes of physical activity daily. Knowledge of
key physiological indicators was significantly associated with educational attainment, gender,
and age group, with lower levels of awareness observed among participants with lower
education, males, and younger adults (p=0.001). The majority of participants (75.0%-96.0%)
reported being aware of the modifiable risk factors for cardiovascular disease. Among the
study participants, nine out of ten agreed that maintaining a healthy lifestyle includes regular
physical activity, exercising, walking short distances, and understanding that hypertension
is harmful and smoking adversely affects the heart. Furthermore, 80–85% reported avoiding
excessive alcohol consumption, and 79% believed that cardiovascular disease is preventable.
To prevent or reduce obesity, a risk factor for cardiovascular disease, 49.0% of participants
reported engaging in regular physical activity, while 33.0% reported following a healthy diet.
Among all study participants, 61.0% had never checked their cholesterol levels, 49.0% had
never measured their blood glucose, and 15.0% had never monitored their blood pressure.
Among respondents exhibiting 1–3 common risk factors, the majority were female, aged
25–34 years, living in rural areas or ger districts, with secondary or specialized secondary
education, employed in government institutions, and had a normal BMI. In contrast, among
those with 7 or more common risk factors, the majority were male, aged 35–44 years, residing
in Ulaanbaatar, living in ger districts, and employed in private organizations.
Conclusion
Most of surveyed participants had sufficient knowledge and positive attitudes toward
modifiable risk factors for cardiovascular diseases (p=0.001). However, they exhibited
inadequate preventive practices related to these risk factors. This indicates the importance
of targeted intervention on behavior change to address this gap.
Result Analysis
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