1.Exploring the Pathogenesis and Prevention Strategies for Recurrence and Metastasis of Ovarian Cancer after Cytoreductive Surgery from the Perspective of"Impairment of Chong-Ren Meridians and Retention of Cancer-Toxin"
Journal of Nanjing University of Traditional Chinese Medicine 2025;41(6):726-729
Given the high recurrence and mortality rates following cytoreductive surgery for ovarian cancer,Professor Wu Mianhua,a nationally renowned(traditional Chinese medicine)TCM expert,proposed that the core pathogenesis of ovarian cancer after cytore-ductive surgery lies in the impairment of the Chong-Ren meridians and retention of Cancer-Toxin.Damage to Chong-Ren meridians is the root cause,and residual cancer toxins are the key.Syndrome differentiation is always based on the deficiency of the root and the ex-cess of the symptoms.In view of the above pathogenesis,the basic treatment method of"regulating Chong-Ren meridians,dissipating turbidity and detoxifying"is established.Harmonizing Chong-Ren meridians consolidates the root,and the treatment is based on meth-ods such as tonifying the kidney and strengthening the spleen,nourishing blood and soothing the liver;dissipating turbidity and detoxif-ying treats the symptoms,and the corresponding methods,such as removing stasis,draining dampness,and resolving phlegm,are used throughout.Clinical application should be tailored based on the roots and symptoms,the degree of urgency,and the characteristics of the syndromes.
2.Analysis of the Idea of Diagnosis and Treatment of Prostate Cancer Based on the Theory of"Strengthening the Root and Clearing the Filth"
Binying YU ; Wenting LI ; Qi ZHANG ; Mianhua WU
Journal of Nanjing University of Traditional Chinese Medicine 2025;41(6):721-725
This paper summarizes the ideas and methods of Professor Wu Mianhua's diagnosis and treatment of prostate cancer based on the theory of"solidifying the root and clearing the filth",and believes that prostate cancer is a combination of deficiency in the root and excess in the manifestation,with deficiency and excess mixed.Spleen and kidney deficiency and cancer toxicity accumula-tion are the basis of prostate cancer,and the mutual entanglement of dampness,phlegm,heat and stasis is the key to the pathogenesis of prostate cancer.Clinically,prostate cancer is diagnosed and treated from the perspective of"solidifying the root and clearing the filth",warming the kidney and nourishing the kidney to consolidate the innate root,strengthening the spleen and activating the spleen to cultivate the acquired root,clearing heat and dampness,resolving phlegm and removing stasis to clear filth and detoxify.Strengthen the root to promote clearing the filth,and clear the fifth to help strengthen the root,achieve dynamic balance,and synergistically con-trol the progression of tumors.
3.Exploring the Pathogenesis and Prevention Strategies for Recurrence and Metastasis of Ovarian Cancer after Cytoreductive Surgery from the Perspective of"Impairment of Chong-Ren Meridians and Retention of Cancer-Toxin"
Journal of Nanjing University of Traditional Chinese Medicine 2025;41(6):726-729
Given the high recurrence and mortality rates following cytoreductive surgery for ovarian cancer,Professor Wu Mianhua,a nationally renowned(traditional Chinese medicine)TCM expert,proposed that the core pathogenesis of ovarian cancer after cytore-ductive surgery lies in the impairment of the Chong-Ren meridians and retention of Cancer-Toxin.Damage to Chong-Ren meridians is the root cause,and residual cancer toxins are the key.Syndrome differentiation is always based on the deficiency of the root and the ex-cess of the symptoms.In view of the above pathogenesis,the basic treatment method of"regulating Chong-Ren meridians,dissipating turbidity and detoxifying"is established.Harmonizing Chong-Ren meridians consolidates the root,and the treatment is based on meth-ods such as tonifying the kidney and strengthening the spleen,nourishing blood and soothing the liver;dissipating turbidity and detoxif-ying treats the symptoms,and the corresponding methods,such as removing stasis,draining dampness,and resolving phlegm,are used throughout.Clinical application should be tailored based on the roots and symptoms,the degree of urgency,and the characteristics of the syndromes.
4.Analysis of the Idea of Diagnosis and Treatment of Prostate Cancer Based on the Theory of"Strengthening the Root and Clearing the Filth"
Binying YU ; Wenting LI ; Qi ZHANG ; Mianhua WU
Journal of Nanjing University of Traditional Chinese Medicine 2025;41(6):721-725
This paper summarizes the ideas and methods of Professor Wu Mianhua's diagnosis and treatment of prostate cancer based on the theory of"solidifying the root and clearing the filth",and believes that prostate cancer is a combination of deficiency in the root and excess in the manifestation,with deficiency and excess mixed.Spleen and kidney deficiency and cancer toxicity accumula-tion are the basis of prostate cancer,and the mutual entanglement of dampness,phlegm,heat and stasis is the key to the pathogenesis of prostate cancer.Clinically,prostate cancer is diagnosed and treated from the perspective of"solidifying the root and clearing the filth",warming the kidney and nourishing the kidney to consolidate the innate root,strengthening the spleen and activating the spleen to cultivate the acquired root,clearing heat and dampness,resolving phlegm and removing stasis to clear filth and detoxify.Strengthen the root to promote clearing the filth,and clear the fifth to help strengthen the root,achieve dynamic balance,and synergistically con-trol the progression of tumors.
5.Preferred retinal locus of eccentric fixation in eyes with high myopia
Yading JIA ; Gaiyun LI ; Mianhua ZHANG
Chinese Journal of Ocular Fundus Diseases 2009;25(5):364-367
Objective To investigate the distribution of the preferred retinal locus (PRL) of eccentric fixation in eyes with high myopia. Methods A total of 40 highly myopic patients (54 eyes) with eccentric fixation were examined by MP-1 microperimeter to identify the PRL. The position of PRL relative to the fovea was estimated using the 90% confidence ellipse of normal adult foveal fixation. The differences of visual acuity between "desirable" and "undesirable" PRL were tested by analysis of variance. Results In 54 eyes with high myopia, 24 eyes (44.44%) had PRL of eccentric fixation below the scotoma after loss of central vision; 19 eyes (35.19%) had a left-field PRL; 6 eyes (11.11%) had an upper-field PRL; and 5 eyes (9.26%) had right-field PRL. In 14 patients who had binocular eccentric fixation, 13 had the same fixation pattern in both eyes, including lower-field PRL in 7 (50.00 %), left-field PRL in 5 (35.71 %), and upper-field PRL in 1 patient (7.14%). The difference of visual acuity between lower- and left-field PRL group and right- and upper-field undesirable PRL group was not statistically significant (F=0.144, P > 0.05). Conclusions The eccentric fixation in eyes with high myopia is usually situated as near as possible to the fovea. The optimal PRL is inferior visual field.
6.Intravitreal triamcinolone injection combined with or without macular grid laser photocoagulation to treat macular edema
Yajian DUAN ; Yading JIA ; Mianhua ZHANG
Chinese Journal of Ocular Fundus Diseases 2009;25(4):270-274
Objective To compare the efficacy of intravitreal triamcinolone(IVTA) injection and IVTA combined with macular laser grid photocoagulation (MLGP) to treat macular edema.Methods Consecutive 89 patients (109 eyes)diagnosed with macular edema by examinations of ocular fundus and optical coherence tomography (OCT).The visual acuity was hand moving- 0.8 (0.19±0.13);the intraocular pressure(IOP)ranged from 7 mm Hg to 21 mm Hg(1 mm Hg=0.133 kPa)and the average IOP was 13.78 mm Hg.All the patients received OCT and microperimetry examinations,the central macular thickness was (570±182) μm;the average light sensitivity was (5.07±3.94) dB and the fixation percentage was 70.67% within 4 ° area around the macular fovea.All the patients received IVTA treatment,39 patients (48 eyes)further received MLGP 1 month later (IVTA-MLGP group).The remaining 50 patients (61 eyes) without MLGP treatment was the IVTA group.Best corrected visual acuity (BCVA),lOP,lens,OCT and microprimetry examinations before and after IVTA (1,3,6,12 months) were followed and analyzed.Results On the 12th months,the BCVA in IVTA-MLGP and IVTA group was (0.41±0.20),(0.24±0.19) respectively (P<0.05);the central macular thickness was (309±187) and (487±206) μm respectively(P<0.05);the mean light sensitivity of 4° central macular was (8.24±4.64)and(6.30±3.22) dB respectively (P<0.05);the fixation percentage was (87.01±19.70)% and (78.85±20.41) % respectively (P<0.05).During the follow-up recurrent macular edema was noticed in 28 eyes of IVTA group and 8 eyes of IVTA-MLGP group.Conclusions IVTA combined with MLG was more effective than IVTA to cure macular edema.
7.Current Situation and Countermeasures of the Rural Human Capital Investment in Guangdong Province
Haizhu TAN ; Mianhua YANG ; Shengguo ZHANG
Chinese Journal of Medical Education Research 2006;0(11):-
Guangdong Province,with its rapid economic development,is one of the fastest provinces of china in the progress of urbanization,while its rural development is relatively laged.The main reason of this phenomenon is: the government paid too much attention to the city,but the investment in human capital to the rural areas is insufficient.In this paper,the reason for the phenomenon is briefly analyzed.
8.Issues to be Paid Attention to in Teacher Training of New Medical Teaching Mode
Shaoxian CAI ; Weiying CHEN ; Mianhua YANG ; Danian QIN ; Jinkun ZHANG ; Bogui WEN
Chinese Journal of Medical Education Research 2005;0(05):-
Teachers are principal parts in the innovation and implementation of teaching.Along with the deepening transformation of new medical teaching mode,higher demands have been set for the construction of teachership and for the education and training of teachers.The article gives an analysis on several issues that should be given attention to in the teacher training.
9.Effects of Lo Central Venous Pressure Decreasing Blood Loss in Lobectomy of Liver Under Ventroscope
Weiming OU ; Mianhua ZHANG ; Hongzhen LIU
Journal of Chinese Physician 2002;0(S1):-
0.05); and there was no significant difference between two groups in variance of renal function 24h after lobectomy. Conclusion WT LCVP is able to obviously reduce patients' blood loss and blood transfusion in lobectomy of liver under ventroscope and has no significant effects on renal function.
10.Clinical study of continuous spinal anesthesia and postoperative analgesia with a “catheter-over-needle” system in aged patients
Chengxiang YANG ; Heng LI ; Mianhua ZHANG
Chinese Journal of Anesthesiology 1996;0(08):-
Objective To evaluate the effect of continuous spinal anesthesia with a "catheter-over-needle" system which diminished the leakage of CSF through the hole in the dura alongside the inserted catheter and minimizes the risk of post-dura-puncture headache. Methods Sixty ASA Ⅰ - Ⅱ patients aged over 60 yr, scheduled for transurethral prostatectomy, were randomly divided into two groups of 30 patients in each group: group I continuous spinal anesthesia (CSA); group Ⅱ continuous epidural anesthesia(CEA) . Catheter was placed at L2-3 or L3-4. Both groups received 0.5% bupivacaine for surgery. A loading dose of 1.5-2.5 ml (groupⅠ ) or 8-13 ml (group Ⅱ) was given. If the surgery exceeded 2 h a third of the loading dose was injected. For postoperative analgesia a mixture of 0.125% bupivacaine + 0.0006% fentanyl was used. In group I the PCA setting was loading dose 0.5ml, background infusion at 0.5 ml/h, bolus dose 0.5 ml and lock-out interval 8 min. In group Ⅱ the loading dose was 2 ml followed by background infusion at 2 ml/h and bolus dose was 2 ml with lock-out interval of 15 min. Onset time and level of analgesia were recorded during surgery and VAS pain score and movement of lower extremities (modified Bromage score) were assessed. Postoperative PCA was maintained for 50 h. Results The demographic data including age, height and body weight were comparable between the two groups. There was no significant difference in the duration of surgery between the two groups. The onset of block was significantly faster in group I (3.5 ?2.3) min than that in the group Ⅱ (9.5 ?3.4) min. Motor blockade was less intense in group Ⅱ as assessed by modified Bromage score. Analgesia was more satisfactory in group I as less patients received fentanyl and droperidol iv during surgery in group I . Thetotal amount of bupivacaine used during postoperative analgesia was significantly less in group I , only about one-fifth of the total amount used in group Ⅱ. Two patients complained of headache in group I but in group Ⅱ there was also one patient complaining of headache. Conclusion Continuous spinal anesthesia has the advantage of faster onset of block, better analgesia, more intense motor block with less local anesthetic.

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