Objective To understand the status of body image disturbance and its influencing factors in patients with ankylosing spondylitis (AS), so as to provide a scientific basis for the clinical management of AS. Methods A total of 353 AS patients admitted from January 2022 to December 2024 were selected as research subjects. Chinese version of Body Image Disturbance Questionnaire (BIDQ) was used to investigate the body image disturbance in AS patients. Single factor analysis was performed by t test and analysis of variance, and multiple factors were analyzed by multivariate linear regression. Results The total score of BIDQ in 342 AS patients was (25.01±4.22). Multivariate linear regression analysis results showed that self-paid medical expense, nighttime VAS score and negative emotion PANAS score could positively predict body image disturbance in AS patients (standardized regression coefficient=0.413, 0.413, 0.460, P<0.05), and PSSS score, positive emotion PANAS score and exercise management CDSSM score could negatively predict body image disturbance (standardized regression coefficient=-0.245, -0.134, -0.247, P<0.05). Conclusion The body image disturbance in AS patients is worthy of clinical attention. Nighttime pain, negative emotion and self-paid medical treatment can increase the risk of body image disturbance. Positive emotion, social support and high self-management level of exercise behavior can reduce the formation of body image disturbance, which can provide new ideas for clinical management of AS patients.

Objective:To explore the influence of individual contraceptive intervention on postpartum women, and to provide basis for widely developing postpartum contraception in the future.Methods:A prospective study was adopted from July 2019 to June 2020 in the Affiliated Hospital of Chongqing Population and Family Planning Science and Technology Research Institute and other seven hospitals, a total of 4200 cases hospitalized delivery female were randomly divided into observation group and control group using random number table, each group included 2100 cases. The observation group was given the following intervention measures: strict education on contraception during delivery in hospital and 42 d after delivery; individualized implementation of contraceptive measures; distribution of contraceptive brochures and condoms; join the contraceptive consultation and communication platform. The control was given routine education and monitoring. After 3, 6, 9 and 12 months of postpartum, the patients were followed up by telephone. All of the information about their postpartum sexual life recovery time, menstruation time, contraceptive methods and use, breastfeeding time, one year of accidental pregnancy and outcomes were obtained.Results:Between observation group and control group, there were significant differences in the awareness rate of postpartum contraceptive knowledge [62.96% (1314/2087) vs. 29.35% (606/2065), P<0.001], the rates of standard contraception [91.71% (1914/2087) vs. 44.94% (928/2065), P<0.001], high-effect and long-effect contraception [28.08% (586/2087) vs. 10.02% (207/2065), P<0.001], accidental pregnancy rate [2.06% (43/2087) vs. 8.04% (166/2065), P<0.001] and induced abortion rate within one year after delivery [1.29% (27/2087) vs. 7.36% (152/2065), P<0.001]. Conclusion:Individualized contraceptive intervention as early as possible after delivery is more conducive to these women to grasp the knowledge of contraception, improve the effective contraceptive rate, avoid unwanted pregnancy, timely maintain the pregnancy interval, protect fertility and ensure reproductive health.

Objective:To explore the influence of individual contraceptive intervention on postpartum women, and to provide basis for widely developing postpartum contraception in the future.Methods:A prospective study was adopted from July 2019 to June 2020 in the Affiliated Hospital of Chongqing Population and Family Planning Science and Technology Research Institute and other seven hospitals, a total of 4200 cases hospitalized delivery female were randomly divided into observation group and control group using random number table, each group included 2100 cases. The observation group was given the following intervention measures: strict education on contraception during delivery in hospital and 42 d after delivery; individualized implementation of contraceptive measures; distribution of contraceptive brochures and condoms; join the contraceptive consultation and communication platform. The control was given routine education and monitoring. After 3, 6, 9 and 12 months of postpartum, the patients were followed up by telephone. All of the information about their postpartum sexual life recovery time, menstruation time, contraceptive methods and use, breastfeeding time, one year of accidental pregnancy and outcomes were obtained.Results:Between observation group and control group, there were significant differences in the awareness rate of postpartum contraceptive knowledge [62.96% (1314/2087) vs. 29.35% (606/2065), P<0.001], the rates of standard contraception [91.71% (1914/2087) vs. 44.94% (928/2065), P<0.001], high-effect and long-effect contraception [28.08% (586/2087) vs. 10.02% (207/2065), P<0.001], accidental pregnancy rate [2.06% (43/2087) vs. 8.04% (166/2065), P<0.001] and induced abortion rate within one year after delivery [1.29% (27/2087) vs. 7.36% (152/2065), P<0.001]. Conclusion:Individualized contraceptive intervention as early as possible after delivery is more conducive to these women to grasp the knowledge of contraception, improve the effective contraceptive rate, avoid unwanted pregnancy, timely maintain the pregnancy interval, protect fertility and ensure reproductive health.

Lipid rafts composed of saturated phospholipids,sphingomyelin,and cholesterol are usually defined as liquid ordered microdomains located in the cell membrane. Lipid rafts are involved in many physiological and pathological processes of cells. Based on the difference in composition and distribution between lipid raft and non-raft domains,a lipid raft probe with aggregation-induced emission (AIE),cholesterol-triethylene glycol-tetraphenylethylene (TCHS-TPE),was designed and synthesized for convenient and specific imaging of lipid raft domains on cell membranes in this study. In this paper,TCHS-TPE was successfully synthesized,and the photophysical properties of TCHS-TPE were measured to evaluate its AIE characteristics. And finally the specific imaging of TCHS-TPE on the lipid raft region of B16F10 melanoma cell membrane was studied using confocal laser scanning microscopy. Compared with the existing lipid raft probe cholera toxin B (CTxB),the TCHS-TPE lipid raft probe has the advantages of simple operation and high specificity. The successful synthesis of the fluorescent probe will provide a useful tool for studying the physiological and pathological processes related to lipid raft domains,and offer a theoretical basis for the design of imaging probes for other lipid raft domains.

A new series of 3-phenyl-3-pyrrolylpentane derivatives are synthesized through modifying the structure of lead compound LG19055,a nonsecosteroidal vitamin D receptor(VDR)agonist.The VDR-agonistic ability of target compounds was measured indirectly by evaluating the differentiation ability of HL-60 cell.The results showed that compounds 13a,13c,13d,13h,13i,13j have excellent VDR-agonistic ability(EC50 <50 μmol /L), especially for compound 13j (EC50 =0.10 μmol /L),which was more potential than that of lead compound LG190155.Their proliferation inhibitory activities in vitro were evaluated by MTT assay in MCF-7,PC-3,Caco-2, HepG2 and L02 cell lines.Compound 13a exhibited significant inhibitory effects on HepG2 cell line(IC50 =0.11μmol /L).Moreover,the inhibitory effect of compound 13a on non-tumor liver L02 cell line was relatively weak (IC50 =15.24 μmol /L ),suggesting that compound 13a has selective inhibitory effects on liver cancer cells.Additionally,HL-60 cell differentiation-inducing activity and the inhibitory effect of cancer cells were posi-tively related.