Rationale and Background: : Maternal anxiety is sometimes considered a normal response to stress or danger and part of the usual human experience. However, it might become a medical condition if happened exaggerated. Anxiety during pregnancy is the most common of psychological problems and estimated to affect between 15 and 23% of women and is associated with increased risk for a range of negative maternal and child outcomes. Objectives: : Describe the difference between high risk pregnant and low risk pregnant related to Anxiety during pregnancy at Mother and children hospital Vientiane capital a Lao PDR. Methodology: : This study was cross-sectional, descriptive study among the pregnant women both in high-risk and low-risk pregnancy conducted from June to December 2023 of the 351 sample size. Data were collected by using questionnaire interviewed face to face for social demographic, obstetric information also medical history and PASS self-rated questionnaire for investigating anxiety symptoms. The data were entered in Microsoft excel and analyzed by using SPSS software. Results: : Of 351 pregnant women, low-risk pregnancy was 57.6% and 42,4% was high-risk pregnancy, these high-risk pregnancy complications for 149 samples shown 21.5% were Advanced maternal age, followed by 17.6% for Anemia and Gestational diabetes mellitus, 14.1% were maternal overweight, 9.4% was previous caesarean, and 12.8% for others. The total PASS score among participants ranged from 0-93 and the mean was 16.3 (SD 11.3) with median 14. There were 109 pregnant women (31.1%) whose PASS score was 21 or higher, and they were defined as they have anxiety symptoms during pregnancy in this study, the incidence of high-risk (n=46, 30.9%) with mild to moderate symptoms (n=41, 27.5%) and Severe symptoms (n=5, 3.4%), also Low-risk group (n=63, 31.1%) with mild to moderate symptoms (n=59, 29.1%) and Severe symptoms (n=4, 2%). Conclusion: the study concludes that the incidence of anxiety symptoms during pregnancy was 31.1% among pregnant women in the Mother and children hospital in Vientiane capital, Lao PDR and associated with social demographic information, Obstetric profile and Medical history. However this study found negative finding that there were no different of anxiety levels comparative of two groups even Low-risk pregnancies has fewer complications and good quality maternal health status.