Background: Nicotine-containing vaporized liquids—composed of propylene glycol, glycerin, water, flavorings, and the thickening agent vitamin E acetate—have been implicated in the development of EVALI. Under conditions of low liquid levels and overheating, these substances release toxic carbonyl compounds (e.g., formaldehyde, acetaldehyde, acrolein). In a 2019 national survey, 3.5% of adolescents aged 13–15 reported cigarette use, and 10% used e-cigarettes. Aim: To study the changes in the behavior, lung, and hippocampal structures of rats due to the effects of electronic cigarettes and their vapor. Materials and Methods: In this study, nineteen 14-day-old SHR rats were exposed to 1 g/mg/day of nicotine and dry hit vapor (control, nicotine and dry hit groups) for four weeks. Behavioral assessments (Open Field Test, Elevated Plus Maze, Conditioned Place Preference), bronchoalveolar lavage (BAL), and histological analysis of lung and hippocampal tissue were conducted. Results: The dry hit vapor group showed significantly reduced body weight (p=0.034), increased anxiety (p=0.006, p=0.025), and avoidance of the smoky chamber. BAL revealed elevated total cells, neutrophils, and macrophages (p=0.01, p=0.04) in both nicotine and dry hit groups. Lung tissue exhibited alveolar septal thickening, inflammation, and emphysema- like changes. Extensive neuronal death was observed in the hippocampus. Conclusion Anxiety-like behavior was observed in both the burn and control groups. Analysis of BAL in the dry hit group revealed inflammation predominantly characterized by macrophage infiltration. Histological examination of lung tissue from both experimental groups demonstrated a reduction in the number of alveoli, accompanied by acute inflammation and thickening of the interalveolar septa. In the hippocampal region, neuronal loss and a reduction in neuronal density were also observed.

The study is devoted to the morphological characteristics of the maturation of lung tissue structures in the fetal period. Fetal histology of the lungs presents the intrauterine development of lung tissue in four successive stages: pseudoglandular, canalicular, saccular and alveolar, each has specific morphological criteria. The following morphological features are predetermined: the development of alveolar epithelium, the ratio of mesenchyme towards the area in alveolar spaces, the degree of proliferation and location of vessels of the microcirculatory bed towards prealveolar partitions. During the fetal period the alveolar columnar epithelium is flattened and differentiates into alveolocytes type I lung histology with the demonstration of histological preparations of the lungs at different stages of intrauterine development. Keywords: fetal lungs, prealveolar structures, pseudoglandular stage, canalicular stage, alveolar stage, alveolar capillary membrane, immunohistochemical study. 16 and II, the area of the mesenchyme gradually decreases and by the birth of a full-term newborn kid it is present mainly in the thickness between the alveolar septa, microcirculation vessels, initially laying deep in the thickness of the mesenchymal tissue, gradually proliferate, approach the pre-alveolar epithelium, channeling it with the formation of alveolar capillary membranes. Air exchange in the lung tissue is mainly provided with two factors: the presence of second-order alveolocytes capable of producing surfactant, and a sufficient formation of alveolias well. This work summarizes the basics of fetal lung histology with the demonstration of histological preparations of the lungs at different stages of intrauterine development.

Abstract Epilepsy, a neurological disorder characterized by recurrent seizures, affects millions of people worldwide. Significant advancements in both diagnostic and therapeutic approaches have greatly improved outcomes, particularly for individuals with drug-resistant epilepsy. Modern neurostimulation techniques such as Responsive Neurostimulation (RNS), Deep Brain Stimulation (DBS), and Vagus Nerve Stimulation (VNS) have demonstrated effectiveness in reducing seizure frequency in these patients. Additionally, emerging technologies like gene therapy and optogenetics are being explored to better understand the underlying mechanisms of epilepsy and hold promise as future treatment modalities.Traditional imaging techniques often fail to detect subtle epileptogenic zones. However, the introduction of ultra high-field 7T MRI scanners represents a major breakthrough. These advanced scanners use eight transmitters to generate higher-resolution images, reducing signal dropout and enabling the identification of previously undetected lesions. In one study involving 31 patients, 58% had their treatment plans modified based on 7T MRI findings, highlighting its potential to inform surgical decision-making. In terms of pharmacological treatment, newer medications such as sultiame, cannabidiol (CBD), and non-pharmacological approaches like the ketogenic diet have emerged as additional therapeutic options for drug-resistant epilepsy. These developments contribute to more effective, personalized management strategies for epilepsy. In summary, the landscape of epilepsy diagnosis and treatment is rapidly evolving. Innovations in imaging and therapeutic interventions are offering new hope for patients with drug-resistant epilepsy. Ongoing research and clinical trials remain essential to further refine these approaches and improve patient outcomes.

Abstract This article included overview of study of Traditional Mongolian prescription Sugmel-7.
The uses of traditional medicine Sugmel-7 collected by Classic books of Mongolian traditional medicine, Prescription of Mongolian traditional medicine textbooks. Overview modern medicine study of Sugmel-7 searched by online Chinese fund of knowledge, research materials of Inner Mongolian University of nationalities. It would be provided traditional prescription Sugmel-7 future study clarification.

Psycho-neurological syndrome which is driver’s health status plays a crucial role in ensuring road traffic safety.GoalThe study aims to determine factors leading to traffic accidents by assessing psycho-neurological status of drivers who caused road traffic accidents.MethodsIt is a double-randomized and cross-sectional study. Drivers caused the traffic accidents in the territory of Bayanzurkh District of Ulaanbaatar city between September 2011 and May 2012 were involved.Following investigations were done:• Thorough neurological examination using a prepared clinical pathway;• EEG test;• Assessment of attention, memory, intellectual speed and anxiety of drivers using Lusher test and computer based test.SPSS 18 was applied in data analysis and chi square test was applied in differentiation the proportions.ResultsThe male-female ratio among 394 drivers was 61.9% and 38.1% respectively. 322 drivers (89.04%) had symptoms of episodic headache, dizziness, blurred vision and unsteadiness. 60 drivers (15.2%) had nystagmus which is the main symptom of vertigo (p<0.001). 159 (40.9%) drivers experienced an insomnia. Epileptic and nonepileptic seizure was observed in 155 cases. Out of 394 drivers 243 (61.6%) had symptoms of anxiety. It was observed that 64.6% had low level of anxiety, 27.9% had medium, 7% had high level and 0.4% had severe anxiety. According to the Shultz table, we found that 46.4% of drivers were disintegrated attention and 12.4% (49) were with slow intellectual speed. The hypomnesia was 27.4% (108).Conclusions:1. According to our study, anxiety is dominated among the drivers and attention is disintegrated and slow.2. EEG results (abnormal II and III) proved that drivers who have epileptic and nonepileptic seizures are involved in the traffic accidents.3. Recurrent neurological conditions like headache, dizziness, insomnia, blurred vision and unsteadiness are preconditions for attention dispel, slowing of attention distribution and anxiety of drivers who caused traffic accidents and those recurrent neurological conditions are prevalent among drivers.

In this study, the effects of traditional drugs such as Zachun-13 and Sampilnorov on serum levels of tumor necrosis factor (TNF) in mice model of arthritis induced by formalin were examined. Moreover, the effect of traditional external therapies including acupuncture, cauterization, pricking-cupping and massage on serum TNF levels in patients with spinal disk herniation and long-term back muscle injury. The study was done at the Research Center of Monos Medical University. Arthritis was induced by formalin (0.5 g/kg) injection into the phalangeal joints of mice. Sampilnorov and Zachun-13 were administered daily through oral tube at concentration of 42.5 mg/kg and 14 mg/kg respectively. Serum levels of TNF were determined 1, 3 and 7 days after initiating the treatment. Acupuncture, cauterization, pricking-cupping and massage were applied to patients once a day for 10 days. After 1 day of treatment, serum levels of TNF was increased 3.09 fold by formalin administration compare to control. This increase was reduced by Sampilnorov and Zachun-13 1.19 and 1.8 fold respectively. Serum levels of TNF were increased 3.0 fold in mice after 3 days of formalin administration. Sampilnorov and Zachun-13 reduced these increases 1.17 and 1.93 fold respectively. Serum levels of TNF increased 15.2 fold in patients with spinal disk herniation and long-term back muscle injury compare to normal range of TNF level. Acupuncture, cauterization, pricking-cupping and massage reduced increased serum levels of TNF in patients 1.3 fold. These results indicate that traditional drugs Zachun-13 and Sampilnorov and traditional external therapies including acupuncture, cauterization, pricking-cupping and massage can be effective for treatment of joint conditions by inhibiting TNF production.