Depressive disorder is a kind of mental disorder characterized by persistent and significant depressed mood, with complex etiology and high recurrence rate. At present, more precise and effective diagnostic and therapeutic approaches are still required. Increasing evidence suggests that hypoxia inducible factor-1 (HIF-1) and related pathways are involved in regulating the development and recovery of depression. HIF-1 enhances neuroplasticity, mitigates neuroinflammatory responses, alleviates oxidative stress, and modulates brain energy metabolism by influencing specific molecules associated with depression. This paper reviews pertinent domestic and international studies, examine the potential mechanisms of HIF-1 in the pathogenesis and progression of depression, and explore antidepressant treatment strategies targeting the HIF-1 signaling pathway. This article provides novel insights into elucidating the pathogenesis of depression and developing innovative therapeutic approaches.

Due to the particularity of their disease and medical habits,cancer patients need to make regular appointments with treatment experts for follow-up visits and monitor disease progression,which can easily lead to a shortage of resources in famous experts' offline clinics.The rise of Internet diagnosis and treatment has realized the reasonable diversion of patients and improved the convenience and timeliness of medical services.In recent years,Cancer Hospital Chinese Academy of Medical Sciences has achieved good results by establishing the outpatient mode of"Internet+famous expert team",integrating the advantages of both,releasing offline space.It introduces the construction ideas,main methods,and achievements of this model,aiming to further improve the outpatient system,and provide references for improving patients experience.

[Objective]To explore and discuss the mechanism of ZHANG Zhongjing's methods of wind medicine in treating delayed-pulse heart disease by applying the theory of wind medicine in Neijing and the understanding of wind medicine by medical practitioners throughout the history.[Methods]Summarize ZHANG Zhongjing's compilation of Treatise on Febrile Diseases and Synopsis of the Golden Chamber,explore the etiology and pathogenesis of delayed-pulse heart disease,as well as the mechanism of wind medicine for restoring meridians,and use modern pharmacological research to demonstrate the effective ingredient targets of wind medicine.[Results]It was found that the causes of wind-induced delayed-pulse included external wind evil,internal liver wind,wind damaging heart Qi and evil obstructing heart meridians which were its basic pathogenesis.The treatment methods of tonifying the heart and supporting the essence,dispelling wind and unblocking the meridians were the main methods.Based on this,a wind medicine complex pulse treatment method was established,and Zhongjing's differentiation and medication were classified into 9 types and 9 methods,forming a series of treatment frameworks,including:regulating and tonifying the Ying Wei,dispelling wind and dispelling evil,clearing upper and warming lower,dispelling wind and dispersing toxins,nourishing Qi and blood,dispelling wind and removing Bi,unblocking Yang and dispersing cold,calming the Ying Wei,resolving phlegm and promoting stagnation,promoting Bi and unblocking the meridians,promoting and clearing spleen,invigorating Qi for relieving desertion,warming kidney and nourishing essence,stimulating Wei Qi,promoting lung and strengthening heart,warming water and drinking method,dispelling wind and unblocking meridians,promoting blood circulation and removing stasis.Furthermore,the mechanism of action of wind medicine in restoring meridians was analyzed,including expelling external wind,relieving liver and dispelling wind,harmonizing Yin and Wei,promoting spleen and clearing blood,resolving phlegm and dampness,promoting blood circulation and unblocking collaterals,nourishing blood,and calming the heart and mind.This was confirmed to be consistent with the effective ingredient targets of modern pharmacological research on wind medicine.[Conclusion]The Zhongjing wind herbal pulse restoration method has significant theoretical guidance and clinical application value in the diagnosis and treatment of refractory bradycardia.

Major depressive disorder (MDD) is a common mental disorder characterized by long-term low mood, anhedonia, and may even lead to suicidal behavior. The development and progression of MDD involves a range of pathological alterations in the central nervous system, including dysfunction of synaptic transmission, hyper-activation of neuroinflammation, and diminished neurogenesis. The transient receptor potential vanilloid 1 (TRPV1) channel is highly expressed in brain regions associated with depression, and can regulate physiological activities such as neuroinflammation, neurogenesis, and synaptic transmission efficacy. Hence, the TRPV1 channel should be implicated in the pathogenesis of depression and be considered as a promising candidate for antidepressant treatment. This paper provides an overview of the structure and function of TRPV1 channel, with a focus on elucidating the potential mechanism of action of TRPV1 channel in depression, and explores its research trajectory and development prospects in the context of depression therapy.

Depressive disorder is a kind of mental disorder characterized by persistent and significant depressed mood, with complex etiology and high recurrence rate. At present, more precise and effective diagnostic and therapeutic approaches are still required. Increasing evidence suggests that hypoxia inducible factor-1 (HIF-1) and related pathways are involved in regulating the development and recovery of depression. HIF-1 enhances neuroplasticity, mitigates neuroinflammatory responses, alleviates oxidative stress, and modulates brain energy metabolism by influencing specific molecules associated with depression. This paper reviews pertinent domestic and international studies, examine the potential mechanisms of HIF-1 in the pathogenesis and progression of depression, and explore antidepressant treatment strategies targeting the HIF-1 signaling pathway. This article provides novel insights into elucidating the pathogenesis of depression and developing innovative therapeutic approaches.

Due to the particularity of their disease and medical habits,cancer patients need to make regular appointments with treatment experts for follow-up visits and monitor disease progression,which can easily lead to a shortage of resources in famous experts' offline clinics.The rise of Internet diagnosis and treatment has realized the reasonable diversion of patients and improved the convenience and timeliness of medical services.In recent years,Cancer Hospital Chinese Academy of Medical Sciences has achieved good results by establishing the outpatient mode of"Internet+famous expert team",integrating the advantages of both,releasing offline space.It introduces the construction ideas,main methods,and achievements of this model,aiming to further improve the outpatient system,and provide references for improving patients experience.

[Objective]To explore and discuss the mechanism of ZHANG Zhongjing's methods of wind medicine in treating delayed-pulse heart disease by applying the theory of wind medicine in Neijing and the understanding of wind medicine by medical practitioners throughout the history.[Methods]Summarize ZHANG Zhongjing's compilation of Treatise on Febrile Diseases and Synopsis of the Golden Chamber,explore the etiology and pathogenesis of delayed-pulse heart disease,as well as the mechanism of wind medicine for restoring meridians,and use modern pharmacological research to demonstrate the effective ingredient targets of wind medicine.[Results]It was found that the causes of wind-induced delayed-pulse included external wind evil,internal liver wind,wind damaging heart Qi and evil obstructing heart meridians which were its basic pathogenesis.The treatment methods of tonifying the heart and supporting the essence,dispelling wind and unblocking the meridians were the main methods.Based on this,a wind medicine complex pulse treatment method was established,and Zhongjing's differentiation and medication were classified into 9 types and 9 methods,forming a series of treatment frameworks,including:regulating and tonifying the Ying Wei,dispelling wind and dispelling evil,clearing upper and warming lower,dispelling wind and dispersing toxins,nourishing Qi and blood,dispelling wind and removing Bi,unblocking Yang and dispersing cold,calming the Ying Wei,resolving phlegm and promoting stagnation,promoting Bi and unblocking the meridians,promoting and clearing spleen,invigorating Qi for relieving desertion,warming kidney and nourishing essence,stimulating Wei Qi,promoting lung and strengthening heart,warming water and drinking method,dispelling wind and unblocking meridians,promoting blood circulation and removing stasis.Furthermore,the mechanism of action of wind medicine in restoring meridians was analyzed,including expelling external wind,relieving liver and dispelling wind,harmonizing Yin and Wei,promoting spleen and clearing blood,resolving phlegm and dampness,promoting blood circulation and unblocking collaterals,nourishing blood,and calming the heart and mind.This was confirmed to be consistent with the effective ingredient targets of modern pharmacological research on wind medicine.[Conclusion]The Zhongjing wind herbal pulse restoration method has significant theoretical guidance and clinical application value in the diagnosis and treatment of refractory bradycardia.

Major depressive disorder (MDD) is a common mental disorder characterized by long-term low mood, anhedonia, and may even lead to suicidal behavior. The development and progression of MDD involves a range of pathological alterations in the central nervous system, including dysfunction of synaptic transmission, hyper-activation of neuroinflammation, and diminished neurogenesis. The transient receptor potential vanilloid 1 (TRPV1) channel is highly expressed in brain regions associated with depression, and can regulate physiological activities such as neuroinflammation, neurogenesis, and synaptic transmission efficacy. Hence, the TRPV1 channel should be implicated in the pathogenesis of depression and be considered as a promising candidate for antidepressant treatment. This paper provides an overview of the structure and function of TRPV1 channel, with a focus on elucidating the potential mechanism of action of TRPV1 channel in depression, and explores its research trajectory and development prospects in the context of depression therapy.

Objective To analyze the effect of Xiaozhi Decoction in the treatment of hyperlipidemiain different classification of physical constitution in TCM.Methods We screened 206 patients with Hyperlipidemia in our hospital and had been treated with drugs during May 2020 to March 2023.Totally 103 patients in the TCM group were treated with Xiaozhi Decoction,103 patients in the western medicine group were treated with atorvastatin.Selected total cholesterol(TC),triglyceride(TG),high-density lipoprotein cholesterol(HDL-C),low-density lipoprotein cholesterol(LDL-C)and liver transaminase before and after a period of treatment.The non-high-density lipoprotein cholesterol(non-HDL-C)will be calculated,too.Results In the Phlegm-Dampness constitution,TC,TG,LDL-C and non-HDL-C decreased significantly all in the TCM group(P<0.05);TC,TG and non-HDL-C decreased significantly all in the western medicine group(P<0.05).The TCM group is superior to the western medicine group in TC,LDL-C,non-HDL-C(P<0.05).In the Qi-Deficiency constitution,TC,TG,LDL-C and non-HDL-C decreased significantly all in the TCM group(P<0.05);TC,LDL-C and non-HDL-C decreased significantly all in the western medicine group(P<0.05).The TCM group is superior to the western medicine group in non-HDL-C(P<0.05).In the Blood-Stasis constitution,TC,TG,LDL-C and non-HDL-C decreased significantly all in the western medicine group only(P<0.05).The western medicine group is superior to the TCM group in TC,LDL-C,non-HDL-C(P<0.05).In the Yin-Yang Harmony constitution,TC and non-HDL-C decreased significantly both in the TCM group(P<0.05).TC,LDL-C and non-HDL-C decreased significantly all in the western medicine group(P<0.05).The western medicine group is superior to the TCM group in TC,LDL-C,non-HDL-C(P<0.05).Conclusion Xiaozhi Decoction is superior to the the atorvastatin in the treatment of hyperlipidemia for the Phlegm-Dampness constitution and Qi-deficiency constitution groups.But it is not superior to the atorvastatin in the treatment of hyperlipidemia for the Blood-Stasis constitution and Yin-Yang Harmony constitution groups.

Objective:To evaluate the clinical effect of orbital fat releasing and repositioning through supra-suborbicularis oculi fat (SOOF) in lower eyelid blepharoplasty.Methods:The authors retrospectively analyzed the clinical data of patients who received lower eyelid blepharoplasty in the Department of Plastic Surgery, Beijing Tsinghua Changgung Hospital from January 2017 to January 2023. Lower eyelid blepharoplasty with orbital fat releasing and repositioning through supra-SOOF was performed. The tear trough ligament and orbicularis retaining ligament were released between the orbicularis oculi muscle and SOOF via skin approach. Orbital septal fat was released to this space, lateral fat flap was fixed to the SOOF capsule, medial fat flap was fixed to the superficial fascia of the levator labii superioris muscle, orbital septum was repositioned, and lateral canthus was suspended. After the operation, lower eyelid morphology and complications were evaluated.Results:A total of 58 patients were enrolled, including 8 males and 50 females with the age of (49.8 ± 10.4) years (32 to 70 years). All patients had obvious lower eyelid bags on both sides, combining the tear trough deformity and (or) palabromalar groove. Fifty-seven patients were followed up for (29.1 ± 16.9) months (6-67 months). All patients were satisfied with the operation. The appearance of lower eyelid was greatly improved, with elimination of fat prominence and tear trough deformity. Mild lower eyelid ectropion was observed two cases 1 week after the operation, and were relieved by moderate massage 2 weeks postoperatively. In one case, mild lower eyelid retraction was observed 1 month postoperatively, with no complaint of discomfort or further treatments. Bulbar conjunctival hemorrhage occurred in 1 case and recovered without further interventions.Conclusion:Lower eyelid blepharoplasty with orbital fat releasing and reposting through supra-SOOF can effectively release the tear trough ligament and the orbicularis retaining ligament, with stronger fat fixation and less surgical difficulty. After the operation, eyelid contour was flat and tight with fewer complications and higher patient satisfaction.