Objective To explore main risk factors associated with stroke among workers in Zhanjiang Base of Offshore Oil Industry , so as to provide scientific evidence for the development of preventive and control measures against stroke .Methods A comparative study was made by using 117 stroke inpatients and the same number of non-stroke patients .By using the same health survey questionnaire , relative medical data , including gender, age, body mass, yeas of service at sea, smoking, alcoholism, blood pressure, diabetes, heart disease, mental stress, cholesterol, triglyceride, low density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol ( HDL-C ) and homocysteine were collected and analyzed .Multiple-factor unconditional Logistic regression analysis was applied to evaluate major risk factors associated with stroke among workers in Zhanjiang Base of Offshore Oil Industry .Results Multiple-factor unconditional Logistic regression analysis showed that the OR value and 95%CI for age were (2.052, 1.041-5.063), hypertension (2.108, 1.104-5.152), smoking (2.452, 1.156 -5.607), diabetes (1.053, 1.031 -3.077), heart disease (1.965, 1.105-4.344), high body mass index ( 2.353, 1.120-4.675), high mental stress (1.854, 1.091-7.501), years of service at sea (1.974, 1.124 -4.351), alcoholism (0.837, 0.784 -0.996), homocysteine (1.221, 1.092-3.325), low-density lipoprotein (1.536, 1.105 -2.227) and high-density lipoprotein (0.313, 0.092-1.025).Conclusions Research results indicated that age , hypertension, smoking, diabetes, heart disease, high mental stress, long years of service at sea, high body mass index, low-density lipoprotein, homocysteine were all risk factors associated with stroke , high-density lipoprotein cholesterol was a protective factor and alcoholism was not a risk factor of stroke .

Objective To explore main risk factors associated with stroke among workers in Zhanjiang Base of Offshore Oil Industry , so as to provide scientific evidence for the development of preventive and control measures against stroke .Methods A comparative study was made by using 117 stroke inpatients and the same number of non-stroke patients .By using the same health survey questionnaire , relative medical data , including gender, age, body mass, yeas of service at sea, smoking, alcoholism, blood pressure, diabetes, heart disease, mental stress, cholesterol, triglyceride, low density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol ( HDL-C ) and homocysteine were collected and analyzed .Multiple-factor unconditional Logistic regression analysis was applied to evaluate major risk factors associated with stroke among workers in Zhanjiang Base of Offshore Oil Industry .Results Multiple-factor unconditional Logistic regression analysis showed that the OR value and 95%CI for age were (2.052, 1.041-5.063), hypertension (2.108, 1.104-5.152), smoking (2.452, 1.156 -5.607), diabetes (1.053, 1.031 -3.077), heart disease (1.965, 1.105-4.344), high body mass index ( 2.353, 1.120-4.675), high mental stress (1.854, 1.091-7.501), years of service at sea (1.974, 1.124 -4.351), alcoholism (0.837, 0.784 -0.996), homocysteine (1.221, 1.092-3.325), low-density lipoprotein (1.536, 1.105 -2.227) and high-density lipoprotein (0.313, 0.092-1.025).Conclusions Research results indicated that age , hypertension, smoking, diabetes, heart disease, high mental stress, long years of service at sea, high body mass index, low-density lipoprotein, homocysteine were all risk factors associated with stroke , high-density lipoprotein cholesterol was a protective factor and alcoholism was not a risk factor of stroke .

Objective To investigate the relationship between the expression patterns of fibronectin (Fn) and its receptors-α5β1 and αVβ3 integrins and angiogenesis after cerebral ischemia in aged mice. Methods Both young (2 months) and aged (18 months) C57BL6 male mice were subject to middle cerebral artery occlusion. The brain endothelial cells (BECs) proliferation was assessed by using dual-immunofluorescent staning (IF) for Ki67 and CD31 and the vessel density was quantified by counting the number of CD31-positive vessels per field of view. The expression patterns of Fn,α5β1 and αVβ3 on blood vessels was assessed by using dual-IF for CD31/ɑ5,CD31/β3 and CD31/Fn. Results The number of CD31/Ki67 dual-positive cells in the penumbra at day 7 after cerebral ischemia of was significantly lower in the aged mice than in the young mice (4.7±0.8/field, P<0.05). The number of CD31-positive vessels in the penumbra at day 7 and 14 of was both significantly lower in aged mice than in the young mice (38.3±3.9/field, 45±4.4/field, both P<0.01). Furthermore, the expression of Fn, α5 and β3 on blood vessels in the penumbra at day 7 after cerebral ischemia was significantly lower in age mice than in the young mice (P<0.05). Conclusions The cerebral angiogenesis after ce?rebral ischemia is impaired in the aged stroked mice, which is associated with the low expression of fibronectin and its receptors-α5β1 andαVβ3 integrins on blood vessels.

Objective To investigate the effects of collateral pathways on prognosis of cerebral infarct patients with prior transient ischemic attack (TIA) and its role in neuroprotective mechanism of TIA. Methods A total of 164 cases of the first ever cerebral infarct patients were consecutively allocated into three groups: A , B and C group according to their age.Three groups were divided into two subgroups respectively based on the absence or presence of prior ipsilateral TIA: A1, A2, B1, B2, C1, C2 group. Neurological dysfunctional scores at admission and 1 month after treatment, barthel index, collateral pathways status, and cerebral infarction volume were evaluated respectively. The relationship between development of collateral pathways and prognosis was assessed at the same time. Results The neurological dysfunctional scores and cerebral infarction volume of patients in A1 group and B1 group were significantly lower than those of A2 group and B2 group (P