1.Research progress of the multi-target anti-inflammatory drugs based on the arachidonic acid pathway
Dan WU ; Longchen CUI ; Fumei XU ; Jie WANG ; Yanli XU ; Qili ZHANG ; Jiaojiao LI ; Lei ZHAO
Journal of China Pharmaceutical University 2025;56(6):782-792
Arachidonic acid can be transformed into a variety of metabolites that trigger an inflammatory response through cyclooxygenase, lipoxygenase, cytochrome P450 enzymes, and other metabolic pathways. Moreover, it plays a key role in the occurrence and development of inflammatory diseases. In recent years, multi-target drugs based on the arachidonic acid metabolic pathway have become an important direction of anti-inflammatory drug research. This article summarizes the opportunities and challenges of arachidonic acid metabolic pathways as well as their interference in the development of anti-inflammatory drugs, reviews the research progress of multi-target drug design, synthesis, and anti-inflammatory activity based on the arachidonic acid metabolic pathway, and discusses the difficulties and prospects of multi-target drugs based on metabolic pathways in anti-inflammatory drug development, aiming to provide some reference and inspiration for the study of multi-target anti-inflammatory drugs based on the arachidonic acid metabolic pathway.
Result Analysis
Print
Save
E-mail