As a distinct pathological factor and metastatic route of malignant tumors,perineural invasion(PNI)exhibits a close association with the prognosis of several cancer types.In recent years,the clinical significance and underlying mechanisms of PNI in gynecological malignant tumors have increasingly drawn research attention.Currently,it is recognized that PNI is clinicopathologically and prognostically linked to cervical cancer and vulvar cancer.The exploration of its mechanisms encompasses multiple gynecological tumors and numerous molecular pathways,including the CCL2/CCR2 axis,NGF/TrkA pathway,GluR2,among others.Nevertheless,the existing research models are fragmented,lacking systematicity and in-depth analysis,thus necessitating integration.This paper presents a comprehensive review of the occurrence of PNI in gynecologic malignancies,its correlations with clinicopathology and prognosis,its implications for surgical approaches and postoperative adjuvant therapies,as well as the potential molecular mechanisms.By synthesizing the advancements in both clinical and basic research,this review aims to offer a solid theoretical foundation for further exploration of the mechanisms underlying PNI in gynecologic malignancies and for the optimization of clinical therapeutic strategies.

As a distinct pathological factor and metastatic route of malignant tumors,perineural invasion(PNI)exhibits a close association with the prognosis of several cancer types.In recent years,the clinical significance and underlying mechanisms of PNI in gynecological malignant tumors have increasingly drawn research attention.Currently,it is recognized that PNI is clinicopathologically and prognostically linked to cervical cancer and vulvar cancer.The exploration of its mechanisms encompasses multiple gynecological tumors and numerous molecular pathways,including the CCL2/CCR2 axis,NGF/TrkA pathway,GluR2,among others.Nevertheless,the existing research models are fragmented,lacking systematicity and in-depth analysis,thus necessitating integration.This paper presents a comprehensive review of the occurrence of PNI in gynecologic malignancies,its correlations with clinicopathology and prognosis,its implications for surgical approaches and postoperative adjuvant therapies,as well as the potential molecular mechanisms.By synthesizing the advancements in both clinical and basic research,this review aims to offer a solid theoretical foundation for further exploration of the mechanisms underlying PNI in gynecologic malignancies and for the optimization of clinical therapeutic strategies.

OBJECTIVE: To analyze the status quo of quantitative classification in Hunan Province catering industry, and to discuss the countermeasures in-depth. METHODS: According to relevant laws and regulations, and after referring to Daily supervision and quantitative scoring sheet and consulting experts, a checklist of key supervision indicators was made. The implementation of quantitative classification in 10 cities in Hunan Province was studied, and the status quo was analyzed. RESULTS: All the 390 catering units implemented quantitative classified management. The larger the catering enterprise, the higher level of quantitative classification. In addition to cafeterias, the smaller the catering units, the higher point of deduction, and snack bars and beverage stores were the highest. For those quantified and classified as C and D, the point of deduction was higher in the procurement and storage of raw materials, operation processing and other aspects. CONCLUSION The quantitative classification of Hunan Province has relatively wide coverage. There are hidden risks in food security in small catering units, snack bars, and beverage stores. The food hygienic condition of Hunan Province needs to be improved.
China ; Food Contamination ; prevention & control ; Food Microbiology ; Food Services ; organization & administration ; Foodborne Diseases ; prevention & control ; Hygiene ; Restaurants ; legislation & jurisprudence

0.05 ) between two groups. The side effects were 7.7 % and 13.3 % in treatment group and control group, respectively. CONCLUSION: The combination of CLA+CBS+Met for 1 wk is an effective and safe treatment for eradication of HP infection with recurrent abdominal in children.