Pharmacological theory based on natural phenomena(abbreviated as natural-phenomena-based pharmacology)belongs to the traditional theory of Chinese herbal medicine,and is originated from Huang Di Nei Jing(The Yellow Emperor's Inner Classic).By analyzing the correlation of four properties and five flavors of medicines with the seasonal changes of nature,Zhang Yuansu,a famous physician of Yuan Dynasty,put forward the view that medicines'properties accord with the features of climatic factors of nature,showing that wind has the properties of ascending and generating,heat has the properties of going up and growing,dampness has the properties of transforming and developing,dryness has the properties of descending and reaping,and cold has the properties of sinking and storing,and then established the theory of natural-phenomena-based pharmacology.As a promotion of the theory,Li Dongyuan advocated that the medication should adapt to the seasonal changes and to the ascending,descending,floating and sinking of qi movement of human body.By reviewing the viewpoints of Zhang Yuansu and Li Dongyuan on natural-phenomena-based pharmacology,this paper discussed the application of natural-phenomena-based pharmacological theory,such as wind-medicine having the properties of ascending and generating,heat-medicine having the properties of going up and growing,damp-medicine having the properties of transforming and developing,dry-medicine having the properties of descending and reaping,and cold-medicine having the properties of sinking and storing,in the identification and treatment of gynecological diseases.The unique way of classification of Chinese herbal medicines according to the theory of natural-phenomena-based pharmacology reflects the view of correspondence between human being and nature.And medication following the theory of natural-phenomena-based pharmacology accords with the thinking of traditional Chinese medicine(TCM),and is in line with the seasonal changes,which reflects the biological rhythm of the human body.Identification of gynecological diseases from the disorders of qi movement,and medication following the theory of medicinal-feature-based pharmacology for gynecological diseases in TCM will provide a novel approach to homotherapy for heteropathy of gynecological diseases in TCM.

Endometriosis(EMs)is a chronic inflammatory disease.It has been proved that inflammatory microenvironment is the key role in EMs occurance and development.Chinese medicine posits that the theory of"same disease of blood and water",which generally refers to"intermingling dampness and blood stasis",serves as a crucial pathogenesis in EMs.The inflammatory microenvironment is the main manifestation of dampness and blood stasis in EMs,while the insufficiency of vital qi results in endogenous dampness.The stagnation of blood stasis serves as the foundation for the formation of intermingling dampness and blood stasis.Based on contemporary theories in molecular biology,the macrophage-mediated inflammatory microenvironment serves as the foundation for the formation of dampness,while the participation of macrophages in angiogenesis is crucial for the formation of blood stasis.Investigating the intrinsic connection between the inflammatory microenvironment in EMs and the theory of"same disease of blood and water"can contribute to a better understanding of the pathogenesis of EMs from a novel perspective.Remodeling of the inflammatory microenvironment in endometriosis by targeting macrophages may provide a new strategy for EMs treatment.

Objective:To systematically review the relationship between PTGER 4 genetic polymorphisms and the risk of inflam-matory bowel disease (IBD).Methods:All eligible case-control studies which published up to February 29,2016 were searched by PubMed,Embase,Web of Science.The studies in accordance with high quality were included in this study .We synthesized pooled odds ratio ( OR) and its 95%confidence interval ( CI) using STATA12.0.The sensitivity analysis was used to determine the stability of re-sults in meta-analysis.The Egger′s analysis was performed to evaluate the publication bias .Results:Twenty original publications invol-ving 44 case-control studies were included in this study ,in which 25179 patients with Crohn′s disease (CD),5261 patients with ulcer-ative colitis ( UC) and 44652 control subjects were detected .The allelic frequency ,additive model ,dominant model and recessive mod-el were used to analyze the association of rs 4613763 T/C polymorphism and CD ,and the pooled OR and 95%CI were as followings:1.24 (1.06-1.45),1.32 (1.06-1.64),1.25 (1.06-1.48),1.28 (1.03-1.59).For rs17234657T/G polymorphism and CD,the pooled OR (95%CI) of four genetic models were 1.35 (1.28-1.47),2.12 (1.70-2.63),1.46 (1.36-1.57) and 1.90 (1.54-2.35),re-spectively.For rs4495224A/C polymorphism and CD,the pooled OR(95%CI) were 1.05 (0.79-1.41),1.08 (0.62-1.88),1.12 (0.75-1.65) and 1.00 (0.67-1.49).And the pooled OR (95%CI) were 0.77 (0.67-0.88),0.59 (0.51-0.69),0.73 (0.61-0.87),0.68 (0.59-0.79) for rs9292777G/T polymorphism and CD.For rs1373692T/G polymorphism and CD,the pooled OR (95%CI) were 1.23 (0.96-1.57),1.39 (0.74-2.59),1.26 (0.74-2.13),1.31 (1.00-1.72).The pooled OR (95%CI) of allelic fre-quency , additive model , dominant model and recessive model for the association of rs 4613763 T/C polymorphism with UC were 1.30 (1.17-1.44 ), 1.73 ( 1.16-2.59 ), 1.32 ( 1.17-1.48 ), 1.64 ( 1.10-2.45 ), respectively.Conclusion: Polymorphisms of rs17234657T/G,rs4613763T/C and rs9292777G/T are associated with CD.Polymorphism of rs4613763T/C is associated with UC sus-ceptibility.

To study the mechanism of Shenkangling (SKL), a compound traditional Chinese herbal medicine, combined with prednisone in treating adriamycin-induced nephropathy in rats.

Objective:To explore the influence of life circumstances on the subjective well-being in children. Methods: A sample of 368 children aged from 10 to 16 years old was administered ISLQ and EMBU. Results: The subjective well-being of children were influenced positively by their parental rearing style of warmth and understanding, and influenced negatively by rearing style of rejection. The favoritism from mother was one of major factor to influence the affective component of subjective satisfaction of children. Also, the following variables of mother's education, achievement in school, sex, and pattern of family affected the subjective well-being in children to varying degrees. Conclusion:The quality of life in children was influenced significantly by their life circumstances, especially parental rearing patterns.

0.05 ). It is indicated that both eight extra-meridians acupuncture therapy and Jin Sanzhen therapy can improve intelligence index of VD, and the possible mechanism is related to the regulation of central nervous system function, elimination of SOD and reduction of NE and NO secretion.

AIM:To improve the quality control standard based on 3 kinds of Radix Isatidis preparations-Radix Isatidis syrup,chewable tablet and granules. METHODS: A TLC method was established for iden tification of with Isatidis indigotica RS,Vleucine CRS and Arginine CRS as the references.A HPLC method was developed for the determination of adenosine and igoitrin in Radix Isatidis Preparations,with DIKMA Diamonsil C_(18) column(5 ?m,200 mm?4.6 mm id),a mixure of acetonitrile-water-triethylamine(10∶90∶0.2,using glacial acetic acid to adjust to pH 5.2)-water(85∶15) as the mobile phase.The detection wavelength was set at 245 nm. RESULTS: Isatidis indigotica,Vleucine and Arginine were detected in all the preparations.The contents of adenosine and igoitrin varied greatly in tested samples from different pharmaceutical enterprises. CONCLUSION: The above methods are simple,accurate,and suitable for the quality control of Radix Isatidis Preparations.

Objective To evaluate the safety of magnesium borate ore powder (MBOP) as a molluscicide, especially for the arsenic content in the soil samples from the fields used MBOP over more than one year. Method The arsenic in the soil samples was assayed by using the AgDDTC method recommended by the government. Result In all of the soil samples, the arsenic contents did not exceed the national health criterion. However, the arsenic in the MBOP treated soil samples was higher than that in the control one′s. Conclusion The application of MBOP as a molluscicide in the fields does cause some side effects on the environment.