ObjectiveTo establish a mouse model of basilar artery dolichoectasia （BAD） and explore the mechanism of modified Tongqiao Huoxuetang （JTQHX） in regulating BAD via phosphatidylinositol 3-kinase （PI3K）/protein kinase B （Akt） pathway. MethodSixty C57/BL6 female mice were randomized into sham operation （injected with 10 U·mL^-1 inactivate elastase）， model， atorvastatin calcium tablets （2.6 mg·kg·d^-1）， and low- and high-dose （crude drug 3.4， 17 g·kg^-1·d^-1， respectively） JTQHX groups. The mouse model of BAD was established by injection with 10 U·mL^-1 elastase. After 14 days of modeling， the sham operation group and model group were administrated with equal volumes of pure water by gavage， and other groups with corresponding drugs for 2 months. The levels of interleukin-6 （IL-6） and calpain （LpA） in the serum were measured by enzyme-linked immunosorbent assay （ELISA）. Verhoeff 's Van Gieson （EVG） staining was employed to observe the pathological changes of blood vessels. Terminal-deoxynucleotidyl transferase mediated nick end labeling （TUNEL） was employed to examine the apoptosis rate of vascular smooth muscle cells （VSMCs）. Image Pro Plus was used to observe and calculate the curvature index， elongation length， percentage increase in vessel diameter， and curvature angle of the basilar artery vessels in mice. Western blot was employed to determine the expression levels of PI3K and Akt in the vascular tissue. ResultCompared with the sham operation group， the model group showed lowered IL-6 level （P<0.01）， no significant change in LpA level， increased apoptosis of VSMCs （P<0.01）， and increased curvature index， elongation length， percentage increase in vessel diameter， and curvature angle （P<0.01）. Furthermore， the modeling up-regulated the protein levels of PI3K and Akt in blood vessels （P<0.01） and aggravated the destruction of the inner elastic layer， atrophy of the muscular layer， and hyaline changes in the connective tissue of the medial membrane of the basilar artery wall. Compared with the model group， 2 months of treatment with JTQHX elevated the IL-6 level （P<0.01）， reduced the apoptosis of VSMCs （P<0.01）， decreased the curvature index， elongation length， percentage increase in vessel diameter， and curvature angle （P<0.05， P<0.01）， and down-regulated the protein levels of PI3K and Akt in blood vessels （P<0.01）. In addition， the treatment alleviated the destruction of the inner elastic layer， atrophy of the muscular layer， and hyaline changes in the connective tissue of the medial membrane of the basilar artery wall. ConclusionJTQHX inhibits the elongation， expansion， and curvature of basilar artery vessels and alleviates the pathological changes by reducing the apoptosis of VSMCs and down-regulating the expression of PI3K/Akt pathway.

Cystic echinococcosis, a zoonotic disease that poses a significant threat to human health and animal husbandry development, is prevalent across the world and predominantly occurs in agricultural and pastoral regions. However, cystic echinococcosis cases are rare in non-endemic areas, which is likely to cause misdiagnosis or missing diagnosis, resulting in delay in treatment. This report presents an overseas imported cystic echinococcosis case misdiagnosed as pulmonary and hepatic cysts, so as to provide insights into diagnosis and treatment of cystic echinococcosis in non-endemic areas.

Objective To explore the correlation between epicardial fat volume(EFV),epicardial fat volume indexed(EFVi)and coronary artery lumen stenosis in young adults.Methods The data of 80 young patients who underwent both coronary computed tomography angiography(CCTA)and coronary angiography(CAG)within 2 weeks were analyzed retrospectively.The correlation between EFV,EFVi and coronary artery lumen stenosis in young adults was evaluated.Results A total of 80 patients were enrolled,taking CAG exomination results as the gold standard,58 cases were enrolled into the lesion group and the other 22 cases were enrolled into the control group.The incidence of coronary artery lumen stenosis was higher in young males than that in young females(t=4.309,P=0.038).EFV and EFVi in the lesion group were higher than those in the control group(t=3.023,P=0.001;t=2.785,P=0.001).The EFV in males was higher than that in females(t=2.558,P=0.012).There was no significant difference in EFVi between male and female groups.The differences between EFV and EFVi of males in lesion group and control group were statistically significant(t=4.083,P<0.01;t=4.429,P<0.01).The differences between EFV and EFVi of females in lesion group and control group showed no sta-tistical significance.EFV and EFVi were moderately positively correlated with coronary artery lumen stenosis(rs=0.437,P<0.01;rs=0.463,P<0.01).Receiver operating characteristic(ROC)curve analysis of EFV and EFVi showed that the area under the curve(AUC)of EFV was 0.784,the cut-off value was 107.24 cm3,the sensitivity was 0.776,and the specificity was 0.682.The AUC,cut-off value,sensitivity and specificity of EFVi was 0.793,53.68 cm3/m2,0.81,0.682,respectively.Conclusion EFV and EFVi are moderately positively correlated with coronary artery lumen stenosis in young adults,which is helpful to the diagnosis of coronary heart disease.However,the differences between EFV and EFVi of young females in lesion group and control group show no statistical significance.

AIM: To report three cases of viral keratitis caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).METHODS: Slit lamp, intraocular pressure, corneal fluorescence staining, anterior segment photography, in vivo confocal microscopy(IVCM), and routine fundus screening were performed in the three confirmed patients. Treatment involved Ganciclovir, artificial tears and glucocorticoid eye drops.RESULTS: Three patients with SARS-CoV-2 keratitis(SCK)recovered well after standard treatment.CONCLUSION: SARS-CoV-2 keratitis typically presents as corneal subepithelial infiltration and can result in a decrease in corneal subepithelial nerve fiber density and an increase in dendritic cells(DC). Antiviral therapy in combination with glucocorticoid has proven to be effective.

The construction of"flagship"hospitals of the synergy of Chinese and Western medicine is promoting of quality development of public hospitals and for enhancing the status and effectiveness of integrated Chinese and Western medicines in the treatment of patients.By collecting data from 62"flagship"hospitals in China,it analyzed the current situation of the construction from the aspects of regional layout,practical experience,and practical problems,and proposed the key paths for the future high-quality development of the"flagship"hospitals of the synergy of Chinese and Western medicines in the light of the policy objectives:adhering to the leadership of Party building,constructing the evaluation index system of the"flagship"hospitals of Chinese and Western medicine collaboration,establishing a long-term safeguard mechanism through the collaboration of multiple main bodies,introducing lean management,and promoting the construction of digital intelligence.

The construction of"flagship"hospitals of the synergy of Chinese and Western medicine is promoting of quality development of public hospitals and for enhancing the status and effectiveness of integrated Chinese and Western medicines in the treatment of patients.By collecting data from 62"flagship"hospitals in China,it analyzed the current situation of the construction from the aspects of regional layout,practical experience,and practical problems,and proposed the key paths for the future high-quality development of the"flagship"hospitals of the synergy of Chinese and Western medicines in the light of the policy objectives:adhering to the leadership of Party building,constructing the evaluation index system of the"flagship"hospitals of Chinese and Western medicine collaboration,establishing a long-term safeguard mechanism through the collaboration of multiple main bodies,introducing lean management,and promoting the construction of digital intelligence.

The construction of"flagship"hospitals of the synergy of Chinese and Western medicine is promoting of quality development of public hospitals and for enhancing the status and effectiveness of integrated Chinese and Western medicines in the treatment of patients.By collecting data from 62"flagship"hospitals in China,it analyzed the current situation of the construction from the aspects of regional layout,practical experience,and practical problems,and proposed the key paths for the future high-quality development of the"flagship"hospitals of the synergy of Chinese and Western medicines in the light of the policy objectives:adhering to the leadership of Party building,constructing the evaluation index system of the"flagship"hospitals of Chinese and Western medicine collaboration,establishing a long-term safeguard mechanism through the collaboration of multiple main bodies,introducing lean management,and promoting the construction of digital intelligence.

The construction of"flagship"hospitals of the synergy of Chinese and Western medicine is promoting of quality development of public hospitals and for enhancing the status and effectiveness of integrated Chinese and Western medicines in the treatment of patients.By collecting data from 62"flagship"hospitals in China,it analyzed the current situation of the construction from the aspects of regional layout,practical experience,and practical problems,and proposed the key paths for the future high-quality development of the"flagship"hospitals of the synergy of Chinese and Western medicines in the light of the policy objectives:adhering to the leadership of Party building,constructing the evaluation index system of the"flagship"hospitals of Chinese and Western medicine collaboration,establishing a long-term safeguard mechanism through the collaboration of multiple main bodies,introducing lean management,and promoting the construction of digital intelligence.

The construction of"flagship"hospitals of the synergy of Chinese and Western medicine is promoting of quality development of public hospitals and for enhancing the status and effectiveness of integrated Chinese and Western medicines in the treatment of patients.By collecting data from 62"flagship"hospitals in China,it analyzed the current situation of the construction from the aspects of regional layout,practical experience,and practical problems,and proposed the key paths for the future high-quality development of the"flagship"hospitals of the synergy of Chinese and Western medicines in the light of the policy objectives:adhering to the leadership of Party building,constructing the evaluation index system of the"flagship"hospitals of Chinese and Western medicine collaboration,establishing a long-term safeguard mechanism through the collaboration of multiple main bodies,introducing lean management,and promoting the construction of digital intelligence.

The construction of"flagship"hospitals of the synergy of Chinese and Western medicine is promoting of quality development of public hospitals and for enhancing the status and effectiveness of integrated Chinese and Western medicines in the treatment of patients.By collecting data from 62"flagship"hospitals in China,it analyzed the current situation of the construction from the aspects of regional layout,practical experience,and practical problems,and proposed the key paths for the future high-quality development of the"flagship"hospitals of the synergy of Chinese and Western medicines in the light of the policy objectives:adhering to the leadership of Party building,constructing the evaluation index system of the"flagship"hospitals of Chinese and Western medicine collaboration,establishing a long-term safeguard mechanism through the collaboration of multiple main bodies,introducing lean management,and promoting the construction of digital intelligence.