The survey on the hesitant status of rubella-containing vaccine (RCV) vaccination was conducted among 2 141 women of childbearing age in four provinces, Liaoning, Jiangsu, Zhejiang, and Anhui, from May 2017 to March 2018. Among the 2 141 study participants, a total of 38.21% (818) of women of childbearing age were aware of rubella and 21.25% (455) of women of childbearing age knew about RCV. Among the 455 women of childbearing age who were aware of RCV, 262 (57.58%) were willing to be vaccinated with RCV; 304 women of childbearing age (66.81%) tended to be vaccinated with RCV free of charge. Among the 193 women of childbearing age who did not want to be vaccinated or did not decide whether they preferred to be vaccinated with RCV, no one around them was vaccinated (89, 46.11%) and fear of vaccine safety (70, 36.27%) were the main reasons for hesitation to receive RCV.

The survey on the hesitant status of rubella-containing vaccine (RCV) vaccination was conducted among 2 141 women of childbearing age in four provinces, Liaoning, Jiangsu, Zhejiang, and Anhui, from May 2017 to March 2018. Among the 2 141 study participants, a total of 38.21% (818) of women of childbearing age were aware of rubella and 21.25% (455) of women of childbearing age knew about RCV. Among the 455 women of childbearing age who were aware of RCV, 262 (57.58%) were willing to be vaccinated with RCV; 304 women of childbearing age (66.81%) tended to be vaccinated with RCV free of charge. Among the 193 women of childbearing age who did not want to be vaccinated or did not decide whether they preferred to be vaccinated with RCV, no one around them was vaccinated (89, 46.11%) and fear of vaccine safety (70, 36.27%) were the main reasons for hesitation to receive RCV.

Objective: To compare the clinical efficacy of anterior column reconstruction using single or double titanium mesh cage (TMC) after total en bloc spondylectomy (TES) of thoracic and lumbar spinal tumors. Methods: A retrospective cohort study was performed involving 39 patients with thoracic or lumbar spinal tumors. All patients underwent TES, followed by anterior reconstruction and screw-rod instrumentation via a posterior-only procedure. Twenty-two patients in group A were treated with a single TMC to reconstruct the anterior column, whereas 17 patients in group B were reconstructed with double TMCs. Results: The overall follow-up is 20.5 ± 4.6 months. There is no significant difference between the 2 groups regarding age, sex, body mass index, tumor location, operative time, and intraoperative blood loss. The time for TMC placement was significantly shortened in the double TMCs group (5.2 ± 1.3 minutes vs. 15.6 ± 3.3 minutes, p = 0.004). Additionally, postoperative neural complications were significantly reduced with double TMCs (5/22 vs. 0/17, p = 0.046). The kyphotic Cobb angle and mean intervertebral height were significantly corrected in both groups (p ≤ 0.001), without obvious loss of correction at the last follow-up in either group. The bone fusion rates for single TMC and double TMCs were 77.3% and 76.5%, respectively. Conclusion Using 2 smaller TMCs instead of a single large one eases the placement of TMC by shortening the time and avoiding nerve impingement. Anterior column reconstruction with double TMC is a clinically feasible, and safe alternative following TES for thoracic and lumbar tumors.

Objective: To compare the clinical efficacy of anterior column reconstruction using single or double titanium mesh cage (TMC) after total en bloc spondylectomy (TES) of thoracic and lumbar spinal tumors. Methods: A retrospective cohort study was performed involving 39 patients with thoracic or lumbar spinal tumors. All patients underwent TES, followed by anterior reconstruction and screw-rod instrumentation via a posterior-only procedure. Twenty-two patients in group A were treated with a single TMC to reconstruct the anterior column, whereas 17 patients in group B were reconstructed with double TMCs. Results: The overall follow-up is 20.5 ± 4.6 months. There is no significant difference between the 2 groups regarding age, sex, body mass index, tumor location, operative time, and intraoperative blood loss. The time for TMC placement was significantly shortened in the double TMCs group (5.2 ± 1.3 minutes vs. 15.6 ± 3.3 minutes, p = 0.004). Additionally, postoperative neural complications were significantly reduced with double TMCs (5/22 vs. 0/17, p = 0.046). The kyphotic Cobb angle and mean intervertebral height were significantly corrected in both groups (p ≤ 0.001), without obvious loss of correction at the last follow-up in either group. The bone fusion rates for single TMC and double TMCs were 77.3% and 76.5%, respectively. Conclusion Using 2 smaller TMCs instead of a single large one eases the placement of TMC by shortening the time and avoiding nerve impingement. Anterior column reconstruction with double TMC is a clinically feasible, and safe alternative following TES for thoracic and lumbar tumors.

Objective: To compare the clinical efficacy of anterior column reconstruction using single or double titanium mesh cage (TMC) after total en bloc spondylectomy (TES) of thoracic and lumbar spinal tumors. Methods: A retrospective cohort study was performed involving 39 patients with thoracic or lumbar spinal tumors. All patients underwent TES, followed by anterior reconstruction and screw-rod instrumentation via a posterior-only procedure. Twenty-two patients in group A were treated with a single TMC to reconstruct the anterior column, whereas 17 patients in group B were reconstructed with double TMCs. Results: The overall follow-up is 20.5 ± 4.6 months. There is no significant difference between the 2 groups regarding age, sex, body mass index, tumor location, operative time, and intraoperative blood loss. The time for TMC placement was significantly shortened in the double TMCs group (5.2 ± 1.3 minutes vs. 15.6 ± 3.3 minutes, p = 0.004). Additionally, postoperative neural complications were significantly reduced with double TMCs (5/22 vs. 0/17, p = 0.046). The kyphotic Cobb angle and mean intervertebral height were significantly corrected in both groups (p ≤ 0.001), without obvious loss of correction at the last follow-up in either group. The bone fusion rates for single TMC and double TMCs were 77.3% and 76.5%, respectively. Conclusion Using 2 smaller TMCs instead of a single large one eases the placement of TMC by shortening the time and avoiding nerve impingement. Anterior column reconstruction with double TMC is a clinically feasible, and safe alternative following TES for thoracic and lumbar tumors.

Objective: To compare the clinical efficacy of anterior column reconstruction using single or double titanium mesh cage (TMC) after total en bloc spondylectomy (TES) of thoracic and lumbar spinal tumors. Methods: A retrospective cohort study was performed involving 39 patients with thoracic or lumbar spinal tumors. All patients underwent TES, followed by anterior reconstruction and screw-rod instrumentation via a posterior-only procedure. Twenty-two patients in group A were treated with a single TMC to reconstruct the anterior column, whereas 17 patients in group B were reconstructed with double TMCs. Results: The overall follow-up is 20.5 ± 4.6 months. There is no significant difference between the 2 groups regarding age, sex, body mass index, tumor location, operative time, and intraoperative blood loss. The time for TMC placement was significantly shortened in the double TMCs group (5.2 ± 1.3 minutes vs. 15.6 ± 3.3 minutes, p = 0.004). Additionally, postoperative neural complications were significantly reduced with double TMCs (5/22 vs. 0/17, p = 0.046). The kyphotic Cobb angle and mean intervertebral height were significantly corrected in both groups (p ≤ 0.001), without obvious loss of correction at the last follow-up in either group. The bone fusion rates for single TMC and double TMCs were 77.3% and 76.5%, respectively. Conclusion Using 2 smaller TMCs instead of a single large one eases the placement of TMC by shortening the time and avoiding nerve impingement. Anterior column reconstruction with double TMC is a clinically feasible, and safe alternative following TES for thoracic and lumbar tumors.

Objective: To compare the clinical efficacy of anterior column reconstruction using single or double titanium mesh cage (TMC) after total en bloc spondylectomy (TES) of thoracic and lumbar spinal tumors. Methods: A retrospective cohort study was performed involving 39 patients with thoracic or lumbar spinal tumors. All patients underwent TES, followed by anterior reconstruction and screw-rod instrumentation via a posterior-only procedure. Twenty-two patients in group A were treated with a single TMC to reconstruct the anterior column, whereas 17 patients in group B were reconstructed with double TMCs. Results: The overall follow-up is 20.5 ± 4.6 months. There is no significant difference between the 2 groups regarding age, sex, body mass index, tumor location, operative time, and intraoperative blood loss. The time for TMC placement was significantly shortened in the double TMCs group (5.2 ± 1.3 minutes vs. 15.6 ± 3.3 minutes, p = 0.004). Additionally, postoperative neural complications were significantly reduced with double TMCs (5/22 vs. 0/17, p = 0.046). The kyphotic Cobb angle and mean intervertebral height were significantly corrected in both groups (p ≤ 0.001), without obvious loss of correction at the last follow-up in either group. The bone fusion rates for single TMC and double TMCs were 77.3% and 76.5%, respectively. Conclusion Using 2 smaller TMCs instead of a single large one eases the placement of TMC by shortening the time and avoiding nerve impingement. Anterior column reconstruction with double TMC is a clinically feasible, and safe alternative following TES for thoracic and lumbar tumors.

Objectives:To investigate the postoperative survival and risk factors in patients with spinal metastases from non-small cell 1ung cancer.Methods:The data of 105 patients with non-small cell lung cancer and spinal metastases who were surgically treated at our hospital between January 2012 and January 2022 were retrospectively collected.The patients were divided into three groups based on the surgical proce-dure,corpectomy with bone cement isolation group(n=33),piecemeal total spondylectomy group(n=46),and total en bloc spondylectomy group(n=26).Demographic characteristics,laboratory test results,radiological examina-tion findings(including spinal involvement,non-spinal bone metastases,visceral metastases,etc.)and pathologi-cal examination results were recorded.Patients'neurological function and general condition were assessed us-ing the Frankel classification,Karnofsky performance scale(KPS)score and Eastern Cooperative Oncology Group(ECOG)score preoperatively and at 1-year follow-up.The 1-year survival rate was evaluated using the Kaplan-Meier method.Risk factors affecting prognosis were identified through univariate analysis(Log-rank test)and confirmed by multivariate analysis(Cox regression model).Results:All the cases had good postopera-tive recovery.Six cases developed incision infections,of which five healed after antibiotic treatment and dressing changes,while one healed after debridement.Seven cases experienced cerebrospinal fluid leakage,and four developed pleural effusions;All recovered after symptomatic treatment.The average follow-up time was 14.4±7.3 months.The average KPS score of the patients improved from 65.4±18.0 preoperatively to 75.1±17.6 postoperatively.The proportion of patients classified as Frankel grades D and E increased from 65.7％before surgery to 81.0％after surgery.The proportion of patients with ECOG scores of 0-1 increased from 40.0％preoperatively to 69.5％postoperatively.The overall survival of the 105 patients was 19.8±1.4 months,and the recurrence-free survival was 15.1±0.8 months.According to Cox regression analysis,preoperative ECOG score(P=0.002),visceral metastasis(P＜0.001),surgical procedure(P=0.02),and immunotherapy(P=0.002)were the independent risk factors affecting the overall survival of patients with spinal metastases from non-small cell lung cancer after surgery.Conclusions:Surgical treatment can significantly improve the neurological function and general condition of patients with spinal metastases from lung cancer.There are no significant differences in the alleviation of clinical symptoms between different surgical methods,but total en bloc verte-brectomy can effectively reduce postoperative tumor recurrence.Preoperative ECOG score,visceral metastasis,surgical approach and immunotherapy are independent risk factors affecting the overall survival of patients.

Objectives:To investigate the postoperative survival and risk factors in patients with spinal metastases from non-small cell 1ung cancer.Methods:The data of 105 patients with non-small cell lung cancer and spinal metastases who were surgically treated at our hospital between January 2012 and January 2022 were retrospectively collected.The patients were divided into three groups based on the surgical proce-dure,corpectomy with bone cement isolation group(n=33),piecemeal total spondylectomy group(n=46),and total en bloc spondylectomy group(n=26).Demographic characteristics,laboratory test results,radiological examina-tion findings(including spinal involvement,non-spinal bone metastases,visceral metastases,etc.)and pathologi-cal examination results were recorded.Patients'neurological function and general condition were assessed us-ing the Frankel classification,Karnofsky performance scale(KPS)score and Eastern Cooperative Oncology Group(ECOG)score preoperatively and at 1-year follow-up.The 1-year survival rate was evaluated using the Kaplan-Meier method.Risk factors affecting prognosis were identified through univariate analysis(Log-rank test)and confirmed by multivariate analysis(Cox regression model).Results:All the cases had good postopera-tive recovery.Six cases developed incision infections,of which five healed after antibiotic treatment and dressing changes,while one healed after debridement.Seven cases experienced cerebrospinal fluid leakage,and four developed pleural effusions;All recovered after symptomatic treatment.The average follow-up time was 14.4±7.3 months.The average KPS score of the patients improved from 65.4±18.0 preoperatively to 75.1±17.6 postoperatively.The proportion of patients classified as Frankel grades D and E increased from 65.7％before surgery to 81.0％after surgery.The proportion of patients with ECOG scores of 0-1 increased from 40.0％preoperatively to 69.5％postoperatively.The overall survival of the 105 patients was 19.8±1.4 months,and the recurrence-free survival was 15.1±0.8 months.According to Cox regression analysis,preoperative ECOG score(P=0.002),visceral metastasis(P＜0.001),surgical procedure(P=0.02),and immunotherapy(P=0.002)were the independent risk factors affecting the overall survival of patients with spinal metastases from non-small cell lung cancer after surgery.Conclusions:Surgical treatment can significantly improve the neurological function and general condition of patients with spinal metastases from lung cancer.There are no significant differences in the alleviation of clinical symptoms between different surgical methods,but total en bloc verte-brectomy can effectively reduce postoperative tumor recurrence.Preoperative ECOG score,visceral metastasis,surgical approach and immunotherapy are independent risk factors affecting the overall survival of patients.

【Objective】 To investigate the value of three hemolysis tests and carboxyhemoglobin (COHb) level in the diagnosis of hemolytic disease of the fetus and newborn (HDFN). 【Methods】 From January 1, 2019 to December 31, 2022, the neonates hospitalized in the Department of Neonatology of Hebei Provincial Children's Hospital with suspected hemolytic disease who had serological testing were retrospectively enrolled in the study. They were distributed into HDFN group and non-HDFN group according to the final diagnosis. Their clinical and laboratory data were collected and analyzed, and the COHb level was detected by blood gas analyzer. 【Results】 A total of 378 neonates with HDFN and 217 neonates without HDFN were included in the study. Most of the neonates in HDFN group were full-term infants (348/378, 92.1%), with median gestational age of 39.1 (38.3, 40.0) weeks. Three hundred and fifty-four cases (354/378, 93.7%) were ABO-HDFN and the rest were Rh HDFN. There were significant differences in the level of serum total bilirubin, hemoglobin, COHb and reticulocyte percentage at admission between the two groups(P<0.05). The positive rate of three hemolysis tests in HDFN group decreased with the increase of the days after birth. The highest positive rate (more than 80%) was observed within 2 days after birth. Correlation analysis showed a negative relationship between the COHb level and the age (rs = -0.434, P<0.001) . Among the three hemolysis tests in HDFN group, the positive rate of antibody release test was the highest (69.0%), followed by the free antibody test (55.6%) and the direct antiglobulin test (DAT) (36.0%). Receiver operating characteristic (ROC) curve analysis showed that the optimal cut-off value of COHb was 1.15%.The sensitivity of COHb ≥ 1.15% was 51.8%, higher than single DAT (36.0%) . The diagnosis effectiveness of three hemolysis tests couldn't be improved when combined with COHb detection(Z = -0.727, P>0.05) . 【Conclusion】 The three hemolysis tests are important in the diagnosis of HDFN, among which the antibody release test has the highest sensitivity. COHb has certain value for the diagnosis of HDFN, but joint testing cannot improve the diagnosis effectiveness of three hemolysis tests. Hemolysis tests and/or COHb detection should be conducted for neonates at risk of hemolysis as early as possible after birth.