Lymphatic filariasis (LF) remains a significant public health challenge in many tropical regions where the disease is endemic. In Malaysia, LF is found in small pockets across the country. Asymptomatic carriers play a critical role in transmission but are often undetected. This report details an investigation of an asymptomatic filariasis reported by local health authorities involving an 83-year-old female patient residing in the Bako area, Sarawak. Despite being immobile due to a stroke, routine screening identified an infection with Brugia malayi through microscopy and a rapid diagnostic test. Interestingly, the patient exhibited no acute or chronic symptoms typically associated with filariasis. Contact tracing among her family members revealed that her son was also infected. Both patients received treatment with diethylcarbamazine (DEC) at a dosage of 6 mg/kg, along with albendazole 400 mg and ivermectin 12 mg. Preventive measures included health education, entomological studies, and the implementation of a ‘Test & Treat Filariasis’ program in the village. By documenting both the index case and a secondary asymptomatic case within the same household, the study provides a strong example of how routine screening and contact tracing can identify hidden sources of infection. This adds significant value to LF elimination strategies and emphasizes the importance of community-level surveillance programs. Coordinated efforts by health authorities, including contact tracing, environmental assessments, and targeted treatment, are essential for controlling the spread of LF and safeguarding public health.

To examine the fate of cryopreserved meniscus used as orthotopic allograft on alternative to total removal of menisci, the authors have performed replacement of medial meniscus with cryopreserved one which had been preserved at −70℃ for 7 days in right side and with fresh autograft without cryopreservation in left side as a control group.Transplanted menisci were sampled at 4, 8, 12 ,16 weeks, postoperatively to observe their gross and histological findings. At 4 weeks, the allograft was healed to the perioheral capsular tissue and meniscal horn attachments of the host by fibrovascular scar tissue retained their normal appearance in gross findings. It showed an increased cellularity immediately adjacent to its peripheral attachment covered by the vascularized synovial tissues. At 8 weeks, it showed even distribution of cellularity in histological finding. At 12 weeks, gross findings of mild shrinkage and degeneration were seen and those were covered by both synovial and connective tissue with regenerated chondrocyte in histological findings. At 16 weeks, a little difference between allograft and normal meniscus was showed in gross and histological findings. There are regenerated chondrocytes in the deep area some degenerative changes were noted in the tibial and femoral cartilage not covered by meniscus. Above results showed cryopreserved meniscal allograft was able to regenerate and clinically suggest good treatment modality in case of unable to reshape to normal structure after total meniscectomy.
Allografts ; Animals ; Autografts ; Cartilage ; Chondrocytes ; Cicatrix ; Connective Tissue ; Cryopreservation ; Horns ; Knee ; Menisci, Tibial