1.Application and Reflection of Simiao Yong'an Tang in Pan-vascular Diseases
Aolin LI ; Kangzheng GUO ; Xitong SUN ; Lerong YU ; Wei ZHOU ; Junping ZHANG
Chinese Journal of Experimental Traditional Medical Formulae 2026;32(21):235-243
Pan-vascular diseases are a group of diseases involving the systemic vascular system, with vascular lesions (especially atherosclerosis) as a common pathological feature. Pan-vascular diseases have attracted widespread attention due to the high healthcare burden that accompanies high morbidity. Inflammation is the core pathogenesis of pan-vascular diseases. Targeted anti-inflammatory strategies have achieved certain success in basic research. However, due to the increased risk of infection, their clinical application has been hindered. Simiao Yong'an Tang (SMYAT), which has the effects of nourishing Yin, detoxifying, and activating blood, demonstrates unique therapeutic advantages. Clinical evidence indicates that SMYAT alone or in combination with conventional Western Medicine/other compound formulas/non-drug therapies can effectively alleviate the clinical symptoms and traditional Chinese medicine (TCM) syndromes of pan-vascular diseases. At the same time, it can reduce the serum levels of inflammatory factors and the risk of infection, improve glucose and lipid metabolism and blood viscosity, and promote wound healing, thereby enhancing the quality of life. The research on the pharmacological material basis indicates that when SMYAT enters the bloodstream, it can be converted into various active components such as harpagide, harpagoside, and chlorogenic acid. Basic research suggests that SMYAT can exert anti-inflammatory effects through multiple pathways and targets, such as interfering with immune cell adhesion and aggregation, macrophage polarization, foam cell autophagy, neovascularization in the outer membrane and plaque, lipid metabolism and cholesterol reverse transport. The current research lacks comprehensive discussion on vascular diseases. In-depth studies on the effects and mechanisms of SMYAT can provide new therapeutic approaches for pan-vascular diseases. Moreover, they help to gain an overall understanding of the disease progression, demonstrating the superiority of the TCM concept of treating different diseases with the same method. This paper provides a systematic overview of the TCM and Western Medicine understanding of pan-vascular diseases, the theoretical framework and material basis of SMYAT, and the progress of clinical and basic research on SMYAT treatment of pan-vascular diseases. The ultimate goal is to provide theoretical evidence and guidance for the development and application of SMYAT in the field of pan-vascular diseases. In the future, further research should be conducted to standardize the compound formula and explore the mechanism of treatment with integrated TCM and Western Medicine.
2.Application and Reflection of Simiao Yong'an Tang in Pan-vascular Diseases
Aolin LI ; Kangzheng GUO ; Xitong SUN ; Lerong YU ; Wei ZHOU ; Junping ZHANG
Chinese Journal of Experimental Traditional Medical Formulae 2026;32(21):235-243
Pan-vascular diseases are a group of diseases involving the systemic vascular system, with vascular lesions (especially atherosclerosis) as a common pathological feature. Pan-vascular diseases have attracted widespread attention due to the high healthcare burden that accompanies high morbidity. Inflammation is the core pathogenesis of pan-vascular diseases. Targeted anti-inflammatory strategies have achieved certain success in basic research. However, due to the increased risk of infection, their clinical application has been hindered. Simiao Yong'an Tang (SMYAT), which has the effects of nourishing Yin, detoxifying, and activating blood, demonstrates unique therapeutic advantages. Clinical evidence indicates that SMYAT alone or in combination with conventional Western Medicine/other compound formulas/non-drug therapies can effectively alleviate the clinical symptoms and traditional Chinese medicine (TCM) syndromes of pan-vascular diseases. At the same time, it can reduce the serum levels of inflammatory factors and the risk of infection, improve glucose and lipid metabolism and blood viscosity, and promote wound healing, thereby enhancing the quality of life. The research on the pharmacological material basis indicates that when SMYAT enters the bloodstream, it can be converted into various active components such as harpagide, harpagoside, and chlorogenic acid. Basic research suggests that SMYAT can exert anti-inflammatory effects through multiple pathways and targets, such as interfering with immune cell adhesion and aggregation, macrophage polarization, foam cell autophagy, neovascularization in the outer membrane and plaque, lipid metabolism and cholesterol reverse transport. The current research lacks comprehensive discussion on vascular diseases. In-depth studies on the effects and mechanisms of SMYAT can provide new therapeutic approaches for pan-vascular diseases. Moreover, they help to gain an overall understanding of the disease progression, demonstrating the superiority of the TCM concept of treating different diseases with the same method. This paper provides a systematic overview of the TCM and Western Medicine understanding of pan-vascular diseases, the theoretical framework and material basis of SMYAT, and the progress of clinical and basic research on SMYAT treatment of pan-vascular diseases. The ultimate goal is to provide theoretical evidence and guidance for the development and application of SMYAT in the field of pan-vascular diseases. In the future, further research should be conducted to standardize the compound formula and explore the mechanism of treatment with integrated TCM and Western Medicine.
3.Music therapy for alleviating cognitive dysfunction in early stroke patients
Lanfen REN ; Lerong SUN ; Jie HUANG ; Yanlin LIAO ; Wei LI ; Dong QIN ; Weijing LIAO
Chinese Journal of Physical Medicine and Rehabilitation 2010;32(1):30-33
Objective To investigate the effects of music therapy in treating cognitive dysfunction in early stroke patients. Methods Forty patients who had suffered a stroke in the previous four weeks were randomly di-vided into two groups of 20. One received music therapy as part of their cognitive training ( observation group) , and the other did not (control group). Before and after 6 weeks of treatment, cognitive functioning was evaluated using the second Chinese edition of Loewenstein's occupational therapy cognitive assessment (LOTCA). The patients' a-bility in the activities of daily living was also evaluated using the modified Barthel index (MBI). Results After treatment, the total LOTCA and MBI scores in both groups were significantly higher than before. Both LOTCA and MBI scores in the observation group were significantly higher than in the control group, and there were also signifi-cant differences between the observation and control groups on all of the LOTCA sub-items except spatial percep-tion. Conclusions Music therapy can improve the effects of rehabilitation on cognition and the ADL ability of early stroke patients.

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