INTRODUCTION: Dysgenesis of the corpus callosum is a brain abnormality  involving  the  large  nerve  fibers  connecting  the  two  hemispheres  of  the  brain.  The  corpus  callosum  connects  the  left  and  right  cerebral  hemispheres  and  facilitates  interhemispheric  communication.  When it is malformed, these functions might be affected.
CLINICAL PRESENTATION: This case report documents a patient with a malformed corpus callosum. She came in for first-onset generalized tonic clonic seizures. As part of a routine workup  for  patients  with  first-onset  seizures,a computed tomography (CT) scan of the brain was done. It revealed dysgenesis  of  the  corpus  callosum.  She  was  started on valproic acid and was discharged improved.
CONCLUSION: Callosal disorders  usually present with some degree of neurologic impairment. The index case however has  no  detectable  neurologic  deficits  and  is  apparently normal.  The  rarity  of  a  dysgenetic  corpus  callosum mandates more epidemiological studies to further elucidate this disease.

Human ; Female ; Adult ; Corpus Callosum ; Seizures ; Valproic Acid ; Agenesis Of Corpus Callosum ; Brain Diseases ; Nervous System Malformations ; Brain ; Cerebrum ; Nerve Fibers ; Epidemiologic Studies

OBJECTIVE

To describe and assess the evidence from randomized controlled trials on the efficacy and tolerability of statins in the prevention of vasospasm after aneurysmal subarachnoid hemorrhage.

METHODS

Data from three relevant studies were retrieved by means of computerized search. Data were extracted on the basis of intention-to-treat principle, the treatment effect was measured as odd's ratio between stalin and placebo. Pooled estimates were computed according to the fixed effects model.

RESULTS

A total of 1 58 patients were included in 3 trials. No significant heterogeneity was found (Q-value =
3.705, df 2, P value = 0.1 57). The combined odds ratio for the responder rate was 0.1 53 in favor of statin, with a 95% Confidence Interval of 0.268 to 0.982. Elevation of ALT and creatine kinase were not significant in the statin group.

CONCLUSION

High-dose statins on top of standard aneurysmal subarachnoid hemorrhage therapy is effective
and safe based on the available trials of small sample size.

Human ; Statins ; Vasospasm