The inaugural hybrid virtual and in-person meeting of the Global Outbreak Alert and Response Network partners in the WHO Western Pacific Region convened on 20–21 November 2024 in Tokyo, Japan. Hosted by the National Centre for Global Health and Medicine and Japan's Ministry of Health, Labour and Welfare, the meeting aimed to enhance regional preparedness and response capabilities for emerging health threats, aligning with the Asia Pacific Health Security Action Framework. The meeting concluded with a consensus on the necessity for sustained engagement, expanded training programs, and strengthened research initiatives to fortify health security across the Western Pacific Region.

The purpose of the present study was to examine the associations of replacing accelerometer-measured sedentary behavior (SB) with physical activity (PA) and depression in a sample of Japanese frail older adults using an Isotemporal Substitution (IS) model. Among 139 frail older adults, accelerometer was utilized to identify the daily average time spent in SB, light-intensity PA (LPA), and moderate- to vigorous-intensity PA (MVPA). Depression was assessed using the Geriatric Depression Scale-Short Version-Japanese (GDS-S-J). The relationship between SB, LPA, and MVPA with depression was examined with three models of multiple regression analysis: single factor model, partition model, and IS model. As results, LPA times was negatively associated with GDS-S-J scores in the single factor model (B = -0.09, p = 0.007) and the partition model (B = -0.13, p < 0.001). In the IS model, replacement of 10 minutes of SB with an equal amount of LPA time showed a significant negative association with GDS-S-J scores (B = -0.09, p=0.003). These results suggest that replacing a small amount of SB with LPA may be associated with an improvement in depression in frail older adults.