1.Metabolic Dysfunction–Associated Steatotic Liver Disease Among Children and Adolescents in a Tertiary Centre in Sarawak
Geraldine Yee Pei Lim ; Victoria David ; Kiew Siong Lau ; Chiong Hung Kiew ; Hooi Peng Cheng
Journal of the ASEAN Federation of Endocrine Societies 2026;41(S1):131-
Introduction:
The global rise in paediatric obesity has led to an increasing burden of metabolic comorbidities, including metabolic
dysfunction–associated steatotic liver disease (MASLD). Obstructive sleep apnea (OSA), characterized by chronic
intermittent hypoxia, has been implicated in the pathogenesis of liver injury. This study aimed to evaluate the prevalence
of MASLD and its association with OSA among children and adolescents in a tertiary centre.
Methodology:
A retrospective cross-sectional study was conducted involving children aged 6–15 years who were admitted for
polysomnography at Sarawak General Hospital between 2024 and 2025. Clinical, biochemical, and lifestyle data were
obtained from medical records and parental questionnaires. Hepatic steatosis was assessed using hepatobiliary ultrasound
in a subset of patients.
Results:
A total of 132 children (mean age 10.8 ± 2.7 years; 87.5% male) were included. The median BMI SDS was 2.50 (IQR: 2.29–
2.93). The mean apnea–hypopnea index (AHI) was 12.0 ± 7.9, with 60% classified as severe OSA.
Among the 16 children who underwent liver ultrasound, MASLD was identified in 81.2%, including five cases of grade
1 and eight cases of grade 2 steatosis. Liver transaminitis was present in six patients. Metabolic comorbidities were
common, with 43.8% requiring metformin for insulin resistance or impaired glucose tolerance, and four patients requiring
antihypertensive therapy.
Unhealthy lifestyle behaviors were prevalent: 64.2% consumed sugary drinks ≥3 times weekly, 42.9% consumed fast food
≥3 times weekly, and only 24.3% reported daily fruit or vegetable intake. Physical inactivity (≤2 times/week) was observed
in 71.4%, while 64.3% had screen time exceeding 2 hours daily.
Conclusion
Children and adolescents with moderate-to-severe OSA exhibit a high burden of metabolic dysfunction, including MASLD.
The findings support a potential contributory role of OSA-related hypoxia in paediatric fatty liver disease and highlight
the need for integrated screening and early intervention in this high-risk population.
Adolescent
;
Child
;
Malaysia
;
Liver Diseases
2.Relapsing retroperitoenal abscess secondary to juvenile dermatomyositis: Complexity in management
Jothinathan Muniandy ; Lau Kiew Siong ; Vanusha Devaraja Pillai
The Medical Journal of Malaysia 2020;75(2):178-180
Juvenile dermatomyositis (JDM) is a systemic autoimmune
condition with myopathy. Gastrointestinal and pulmonary
manifestations are rare presentation of JDM.
Gastrointestinal perforation incidence in JDM is associated
with vasculopathy and ischaemia. There are only few
reported case of management of JDM with gastrointestinal
complication. Management of such condition is challenging.
We present a 21-year-old man with spontaneous descending
colon perforation undergoing Hartmann’s procedure. He
subsequently presented with recurrent retroperitoneal
abscess at five and 30 months following the initial
presentation which was treated with percutaneous drainage.
A high index of suspicion is necessary in JDM patients
presenting with acute abdomen


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