Background: Identifying reliable biomarkers for early detection, risk stratification, and prognosis of CVD in the context of CKD is, therefore, of critical importance. Cystatin C has emerged as a potential biomarker capable of reflecting both cardiac injury and renal impairment, particularly in patients with arterial hypertension. This study aimed to evaluate the association between serum cystatin C levels, left ventricular hypertrophy, and chronic kidney disease in individuals with hypertension. Objective: To assess serum cystatin C concentrations in patients with left ventricular hypertrophy and chronic kidney disease secondary to arterial hypertension. Materials and Methods: A case-control analytical study was conducted, enrolling 44 patients aged 45 years or older with both left ventricular hypertrophy and chronic kidney disease due to arterial hypertension alongside a control group of apparently healthy individuals. Serum cystatin C levels were measured using immunoturbidimetric assay. Statistical analysis was performed using SPSS version 25.0. Group comparisons were made using independent-sample t-tests, while multivariate regression and receiver operating characteristic (ROC) analyses were employed to explore associations and the predictive value of cystatin C. Results: The mean serum cystatin C concentration in the case group was 1.6±0.1 mg/L, significantly higher than in the control group (0.88±0.03 mg/L, p<0.05). Similarly, the estimated glomerular filtration rate (eGFR) was markedly reduced in the case group (44.88±6.8 mL/min/1.73 m²) compared to the controls (92.88±3.4 mL/ min/1.73 m², p<0.05). In the case group, a statistically significant inverse correlation was observed between serum cystatin C levels and glomerular filtration rate (GFR), with a regression coefficient of β=−0.028 (p<0.006). Conclusion The elevated serum cystatin C levels (1.6±0.1 mg/L) and decreased eGFR (38.99±12.7 mL/min/1.73 m²) observed in the case group suggest that cystatin C may serve as a potential biomarker for the early diagnosis of left ventricular hypertrophy due to arterial hypertension and chronic kidney disease, as well as for predicting related complications.

Background: The capital city of Mongolia, Ulaanbaatar is not only one of the coldest capitals in the world but has also become one of the most polluted cities in recent years due to the prolonged effects of severe cold. According to the World Health Organization (WHO), the most harmful air pollutant to human health is PM2.5. These fine particulate matters can penetrate the human body through the respiratory tract, causing various changes in the body and the oral cavity. Aim: Relationship between dental caries, gingivitis and periodontal status and PM2.5 air pollutant levels among 12 years old children in different areas of Ulaanbaatar. Materials and Methods: The study population consisted of 190 children aged 12 years old, who were selected from high and low level areas with air pollutant PM2.5 in Ulaanbaatar city, Mongolia. We obtained informed consent No.24-25/10-1 of the Ethical Committee, MNUMS. The oral examination of every child was done according to WHO recommendation (2013). We determined the prevalence of dental caries and mean DMFT score, and the prevalence of gingivitis, and CAL score. Statistical analysis was done by the SPSS 29 software. Results: The prevalence and mean DMF/t score of dental caries were 96% аnd 5.37±2.75 among children living in the high level area of the PM2.5 air pollutant; and 91% and 5.39±3.95 in the low level area, respectively (p<0.01). The prevalence of gingivitis was 23.2% among all children; 25.2% among children living in the high level area of the PM2.5 air pollutant and 20.5% in the low level area. The CAL score was 1.89±0.89 mm in the high polluted area and 1.94±0.77 mm in the low polluted area (p<0.001). Conclusion The prevalence of dental caries and gingivitis and the mean DMFT and CAL score among children living in air polluted areas were higher than low polluted areas.

Background: Background: In recent years, ensuring a safe and healthy working environment for mining employees, improving working conditions, protecting and promoting health, and paying attention to other factors affecting health have become essential requirements. While infectious diseases, noncommunicable (chronic) diseases, nutritional disorders, occupational injuries, and mental health conditions are the main indicators for assessing the health impact on mining workers, there is still a lack of research on noncommunicable diseases among mining sector employees in Mongolia. This gap served as the basis for the present study. Aim: To study the risk factors of noncommunicable diseases among employees of Erdenet Mining Corporation Materials and Methods: A total of 303 employees from 15 divisions of Erdenet Mining Corporation participated in the study. Participants belonging to high-risk groups for noncommunicable diseases were selected using a purposive sampling method. The survey questionnaire was developed based on the WHO STEP wise approach to Surveillance (STEPS) of noncommunicable disease risk factors. Results: Of all participants, 70% were male and 30% were female, with an average age of 46 years. The average total duration of employment was 23 years, of which male employees had worked an average of 19.3 years and female employees 17.3 years at Erdenet Mining Corporation. Among participants, 48.5% had never smoked, while 38.3% were current smokers. When analyzing alcohol consumption by job position, it was found that 85.7% of managers and 66.7% of administrative and decoration workers had high levels of alcohol consumption. Regarding physical activity, 23% of male and 15.2% of female employees reported engaging in active exercise more than three days per week, indicating that male employees were more physically active than females. In terms of dietary habits, 28.3% of males and 17.6% of females did not control their salt intake. As for eating patterns, 53.6% of employees regularly had breakfast, 77.3% regularly had lunch, and 76.6% regularly had dinner at a fixed time. Conclusions 1. Among the employees surveyed, 48.5% had never smoked, while 38.3% were current smokers. Daily smoking was most prevalent among employees aged 35–54 years (74.2%), with the 25–34 age group also showing a relatively high rate of smoking. Regarding alcohol consumption, 38.2% of male employees reported drinking vodka or similar alcoholic beverages. Alcohol consumption was significantly higher among males compared to females, indicating that it is a major risk factor for noncommunicable diseases (p=0.003). 2. In terms of dietary patterns, 53.6% of employees reported regularly having breakfast, 77.3% regularly had lunch, and 76.6% regularly had dinner. Eating habits varied by gender. Concerning physical activity, 23% of male employees and 15.2% of female employees engaged in regular exercise, indicating that male employees were more physically active than females. The study found that lifestyle and behavioral factors such as smoking, alcohol consumption, insufficient physical activity, and poor dietary habits contribute to an increased risk of noncommunicable diseases among employees.

Background: Researchers have identified that occupational exposures related to mining operations-such as dust, noise, and vibration—can increase the risk of developing occupational diseases, including pneumoconiosis, hearing loss, and spinal injuries, as well as noncommunicable conditions such as hypertension and cardiovascular diseases. Work-related stress, living away from family, reliance on portable food services, and shift work systems also contribute to weight gain and negatively affect endocrine function. Aim: To investigate the prevalence of metabolic syndrome and noncommunicable diseases among employees of Erdenet Mining Corporation Materials and methods: A total of 303 employees from 15 divisions of Erdenet Mining Corporation participated in the study. Participants included employees with 10–20 years or more of service; 15% were female, and 75% were technical workers. Employees belonging to high-risk groups for noncommunicable diseases were selected using a purposive sampling method. Results: When analyzing body mass index (BMI) by occupation, overweight or obesity was found among 79.2% of service workers, 65% of electricians, 100% of fuel distributors, 77.8% of decorators, 75.5% of mechanics, 94.7% of specialists, 86.4% of professional workers, 75.7% of operators and engineers, and 88.9% of administrative staff. Central obesity was also analyzed by job position, revealing that 79.2% of service workers, 60% of laboratory staff, 35% of electricians, 64.9% of operators and engineers, and 66.7% of administrative employees had central obesity. Among all participants, 20.7% had a previous history of cardiovascular disease, of whom 71.4% were male and 28.6% were female. The mean blood glucose level among participants was 6.0 mmol/L, with a median of 5.6 mmol/L, a minimum of 3.9 mmol/L, and a maximum of 18.3 mmol/L. The median glucose level was 0.2 mmol/L lower than the national average. No statistically significant difference in blood glucose levels was found between males and females (p = 0.135). By job position, elevated blood glucose levels (prediabetic range) were found in 62.5% of service workers, 40% of laboratory staff, 35% of electricians, 71.4% of managers, and 55.6% of administrative employees. Conclusion The findings indicate an increasing trend in metabolic and cardiovascular risk factors among employees of Erdenet Mining Corporation SOE.

Background: The first confirmed case of COVID-19 in Mongolia was reported on November 11, 2020. In response, the government imposed a nationwide lockdown, which significantly impacted the population’s mental health. Heightened levels of stress, anxiety, loneliness, and depression during the pandemic altered individuals’ psychological stability and behavior. Personality traits—defined as relatively stable patterns of emotion, cognition, and behavior—play a key role in stress responses and emotional regulation under pressure. Emerging evidence suggests that these psychological factors may influence the immune system’s responsiveness, including vaccine-induced antibody production. Aim: To evaluate the association between post-vaccination antibody responses and personality types following two doses of COVID-19 vaccines. Materials and Methods: A total of 738 participants who received two doses of COVID-19 vaccines (AstraZeneca ChAdOx1, n=29; Pfizer-BioNTech, n=119; Sinopharm BBIBP, n=590) and had no prior SARS-CoV-2 infection were enrolled. Serum samples were collected 21–28 days after the second dose, and SARS-CoV-2 RBD (S) IgG antibodies were measured using ELISA (Proteintech Inc., USA). Personality types were assessed using a 56-item temperament questionnaire developed by A. Belov, categorizing individuals into classical temperament types (choleric, phlegmatic, sanguine, melancholic). Logistic regression and ROC analysis were used to examine associations between personality types and antibody response. Results: The presence of an antibody response was significantly higher among individuals with a melancholic temperament, and significantly lower among those with a phlegmatic temperament. Furthermore, antibody titers were higher in participants with melancholic and sanguine temperaments and lower in those with a phlegmatic type. Conclusions 1. During the early period following the second dose of COVID-19 vaccination, the antibody response was higher in individuals with a pure melancholic temperament, while it was lower in those with a phlegmatic temperament. 2. After the second dose of the Sinopharm BBIBP COVID-19 vaccine, antibody titers were higher in individuals with pure melancholic and sanguine temperaments, and lower in those with a phlegmatic temperament.

Background: In the treatment of plaque-induced gingivitis, in addition to mechanical plaque control, the use of chemical plaque control such as mouth rinses for a certain period has shown a positive effect on treatment outcomes and prognosis. Aim: To evaluate the efficacy of a probiotic mouthwash in the treatment of plaque-induced gingivitis. Materials and Methods: A randomized controlled clinical trial was designed for a period of 2 weeks on 45 systemically healthy subjects between 20 and 25 years having plaque-induced gingivitis. The study population was divided into three groups. Group 1-15 subjects were advised experimental (probiotic) mouthwash. Group 2-15 subjects were advised positive control (chlorhexidine) mouthwash and Group 3-15 subjects into a negative control group. Oral prophylaxis was done for all groups at baseline. After the proper oral hygiene instructions, groups 1 and 2 were instructed to rinse their mouth with 15 ml of their respective mouthwashes, for 1 min twice daily, 30 min after brushing. Clinical parameters such as Full mouth plaque score (FMPS), Full mouth bleeding score (FMBS) were assessed at baseline, 2 weeks respectively. Results: At baseline, there was no statistically significant difference between the groups in terms of FMBS and FMPS mean values (p=0.174, p=0.887). At day 14, the FMPS, FMBS mean values were significantly reduced by all treatment modalities ranking probiotic and chlorhexidine is greater than negative control group (p<0.001, p<0.001). Conclusion The probiotic mouthwash was effectively used as an adjunct to mechanical plaque control in the treatment of plaque-induced gingivitis.

Background: In recent years, work-life balance has become a pressing issue for healthcare workers in many developing countries around the world. An imbalance between work and personal life leads to psychological stress, health problems, loss of self-confidence, job dissatisfaction, and decreased work productivity due to an inability to concentrate. It also results in a decline in the quality of treatment and services. Furthermore, it increases the risk of medical errors and contributes to both physical and mental burnout, ultimately leading to resignation. Aim: The study analyzed the work-life balance and turnover intentions of employees at family health centers. Materials and Methods: The study was conducted using a cross-sectional model and a quantitative survey method. The work-life balance of employees at Family Health Centers was examined using the work-life balance assessment question naire developed by Hayman (2005), and turnover intentions were assessed using the standard questionnaire developed by Auerbach et al. (2014). The research was carried out in 2024. The study included 123 employees from 22 Family Health Centers located in the Bayangol, Bayanzurkh, Sukhbaatar, Songinokhairkhan, Khan-Uul, and Chingeltei districts of Ulaanbaatar. Results: Of the participants, 95.1% were female, with an average age of 35.2±9.5. Among them, 55.3% were doctors, 29.3% were nurses, 9.8% were health social workers, and 5.7% were other non-medical staff. The income of Family Health Center employees was found to be insufficient; 8.9% had incomes below the minimum subsistence level, and their ability to meet basic household needs was very limited. The results show that participants’ work negatively impacted their personal life (WIPL–23.5), and personal life negatively affected their work (PLIW–15), both of which scored high. Meanwhile, the positive interaction between work and personal life (WPLE–10.7) was low, indicating a disruption in their work-life balance. Working overtime was statistically significant in relation to work-life imbalance (p=0.038). As age and years worked at the current organization increased, the negative impact of work on personal life and personal life on work tended to decrease. Conclusion The work-life balance of Family Health Center employees has been disrupted. The level of work negatively affecting personal life and personal life negatively affecting work is high. 65% of Family Health Center employees are considering leaving their current organization, and 41% are considering leaving the healthcare field.

Background: In recent years, the incidence of liver diseases due to complications of non-alcoholic fatty liver disease (NAFLD) has shown a significant upward trend in Southeast Asian countries. NAFLD is a hepatic disorder characterized by lipid accumulation in the microstructure of the liver in individuals who consume little to no alcohol. It is often associated with insulin resistance and is diagnosed when steatosis affects more than 5% of hepatocytes histologically, or when the fat signal intensity on MRI exceeds 5.6%, based on fat-to-water ratio measurements. In Mongolia, histological studies using frozen liver sections with routine and special staining techniques are limited, highlighting the necessity of this study. Aim: To determine and compare the degree of steatosis and fibrosis in frozen liver tissue samples of patients with NAFLD through histological analysis. Materials and Methods: This study was conducted at the the Department of Anatomy, School of Biomedicine and Bio medical Research Institute of MNUMS in collaboration with the Second State Central Hospital. Ethical approval was obtained from the Research Ethics Committee of MNUMS (Protocol No. 2024/3-06). All procedures adhered strictly to laboratory biosafety protocols. Participants were selected among patients undergoing elective laparoscopic cholecystectomy, from whom informed consent was obtained. Based on inclusion criteria, five participants were grouped as follows: healthy control (n=1), NAFLD without fibrosis (n=2), and NAFLD with fibrosis (n=2). Liver biopsies (approx. 1 cm in size) were obtained intraoperatively, immediately deep-frozen in liquid nitrogen, and prepared for histological evaluation. Results: In patients with NAFLD compared to the healthy liver group, disruption of hepatocyte columnar architecture and mild periportal lymphocytic infiltration were observed. Oil Red O staining revealed 34–66% micro- and macrovesicular steatosis, corresponding to grade 2 steatosis. Masson’s trichrome staining showed no fibrotic changes in perivenular or periportal areas (Ishak grade 0/4) at this stage. However, upon progression to grade 3 steatosis, early-stage fibrosis was observed in both perivenular and periportal regions (Ishak grade 1/4). Further progression to stage 4 fibrosis was characterized by the development of connective tissue septa, although no significant changes in droplet size were observed. Conclusions 1. Increasing stages of fibrosis are not directly influenced by the severity of hepatic steatosis in NAFLD. 2. Although the degree of steatosis increases, the absence of corresponding fibrotic changes in early stages indicates a complex progression pattern of NAFLD requiring further investigation.

Background: Cleft lip and palate (CLP) is a congenital anomaly that accounts for approximately 65% of all craniofacial malformations. In Mongolia, the prevalence of CLP is estimated at 0.93 to 1 per 1,000 live births, which is comparable to the global average but slightly higher than the average reported among Asian countries. The incidence is observed to be twice as common in males compared to females. Diagnosis: The patient is a 15-year-old male with a history of congenital unilateral cleft lip and palate. He underwent primary surgical repair of the cleft at the age of 9. As of May 2022, clinical examination revealed maxillary hypoplasia, anterior crowding, and a combination of bilateral posterior and anterior crossbite. Cephalometric analysis demonstrated a skeletal Class III malocclusion with midfacial deficiency. Treatment: Orthodontic treatment was initiated in October 2022 using a non-removable, self-ligating bracket system (MBT 0.022” slot, stainless steel). In the first month, CuNiTi 0.014 archwires were placed, and cross elastics were applied from the maxillary to mandibular canines on the left side for two months. On December 10, 2022, CuNiTi 0.014×0.025 archwires were placed in both arches, accompanied by coil springs to open space. Subsequent phases involved transitioning to stainless steel (SS) and titanium-molybdenum alloy (TMA) archwires for alignment and leveling. Treatment Outcome: At the end of treatment, a Class I molar and canine relationship was achieved. The axial inclinations of the upper and lower incisors reached normative values based on lateral cephalometric analysis. The maxillary arch form was expanded and improved to a more ideal rounded contour. Dental crowding was resolved without extraction, and both transverse and sagittal occlusal relationships were significantly improved. Conclusion This clinical case demonstrates that fixed orthodontic treatment in a patient with unilateral cleft lip and palate can effectively correct dental crowding, normalize occlusal relationships, and significantly improve facial esthetics, phonetics, and overall quality of life. Orthodontic intervention played a vital role in restoring function and supporting psychosocial and physical development.

Background: Children with developmental disabilities benefit from support in motor skills, sensory processing, cognitive development, and social skills. Mongolia has trained occupational therapists for a decade, with 37% specializing in pediatrics, but long-term therapy facilities remain limited. Aim: This study provides a case report on a child with developmental disabilities who received occupational therapy to evaluate improvements in sensory processing, social communication, and daily living skills. Materials and Methods: The study participants were purposively selected from children undergoing occupational therapy at the “Enerel” Child Development Center. Participant A is a 16-year-old male with hearing and speech impairments, as well as an intellectual disability. The initial assessment showed poor sensory processing and behavioral problems and communication difficulties. A tailored program incorporating sensory-based therapies, communication cards, and sign language was developed with caregiver collaboration. Occupational therapy was conducted five times weekly for 11 weeks. Pre and post test assessments included goal attainment scaling (GAS) and Sensory profile 2 (Child). Results: The participant showed improved communication using cards and sign language, better emotional regulation, enhanced sensory processing, and reduced hyperactivity to external stimuli. Goal Achievement (GAS) +2, meaning the goal was achieved better than expected and positive changes were found on the Sensory profile 2, with large effect sizes. Conclusion The study found that sensory- based occupational therapy and sign language training improved occupational performance and goal achievement in children with sensory, behavioral, and communication difficulties.