1.A comparative study of the mechanism of action of Dmar chen-13 on wind-blood ascending disease and its effect in dexamethasone-induced hypertension pathological model
Ulaan-Оd Kh ; Khastana M ; Anu A ; Khaliunaa B ; Chimedragchaa Ch ; Bold Sh
Mongolian Medical Sciences 2023;205(3):20-26
Background:
Some scholars believe that the study of ancient medical works to gain insight into their scientific
concepts and correctly understand the profound techniques of doctors are very important to the
development of traditional medicine in the 21st century. Cardiovascular disease, the third leading
cause of morbidity in Mongolia's population, was 936 per 10,000 people in 2021, an increase of
128 over the ten-year average and 68 decreased the previous year. According to 2021 statistics,
cardiovascular diseases remain the leading cause of death in the population, with 5000-5500 deaths
per year, or one death in every three people. In 2021, hypertension accounted for 51.6 percent of
cardiovascular diseases, an increase of 7.9 percent from 2012.
Goal:
To analyze the mechanism of action of Marcin-13 on the wind-blood ascending disease and compare
with its effect on the pathological model of hypertension induced by dexamethasone.
Materials and methods:
In our study, we used the book named "Oral Instruction Tantra" as main reference material and for
research methods, we used the checklist method to list relevant information about the pathogenesis
of wind-blood ascending disease and Dmar chen-13 traditional medicine from the literature, so as
to provide preconditions for further analysis. The pathogenesis of wind-blood ascending disease
and the mechanism of action of Dmar chen-13 were analyzed by theoretical analysis methods and
the comparison method was used to contrast the mechanism of action of Dmar chen-13 on the
wind-blood ascending disease and its effect on the pathological model of hypertension induced by
dexamethasone.
Results
The mechanism of action of Dmar chen-13 in the treatment of wind and blood ascending disease is to
transform pathological blood into physiological blood so as to adjust the disorder of wind and blood and
finally achieve the purpose of treatment. We compared the mechanism of action of Dmar chen-13 on
wind and blood ascending disease with its effect on the dexamethasone-induced hypertension model.
Inhibiting the release of renin, angiotensin and aldosterone is equivalent to transforming pathological
blood into physiological blood, opening up blood vessels, and balancing wind and blood disorders in
traditional medicine.
2.Analyzing additional methods of the prescription in the “Man ngag bdud rtsi zegs ma” written by khamba Nomun Khan Luvsandanzanjantsan
Khastana M ; Pingcuodajie ; Sumiyatseren B ; Ulaan-Od H ; Bold Sh
Mongolian Pharmacy and Pharmacology 2022;20(1):86-90
Abstract:
Mongolian traditional medicine is an enormous knowledge that has been battling with long term diseases of Mongolian ancestors by gaining experience, analyzing and learning from foreign medicinal theory and practice for 5000 years. Throughout this long historic evolution Mongolian scholars have published many writings about diagnosis, treatment, medicines and ingredients and among these arised Mongolian traditional medicine theory and practice.
The development basis of XXI century traditional medicine are the books and writings of previous doctors, scientists’ knowledge and search through them in depth about practice, medicine especially ingredients and their correlation backgrounds are essential.
Purpose:
Analyzing additional methods of the prescription included in the “man ngag bdud rtsi zegs ma” written by Khamba Nomun Khan Luvsandanzanjantsan
Methods:
Methods of check list, textual analysis for ancient books and analysis and synthesis were used in the study.
Conclusion
There ara 47 prescription for the addition medicine included in the “man ngag bdud rtsi zegs ma” written by Khamba Nomun Khan Luvsandanzanjantsan. We classified them into 4 categories as supporting medicine, ruling medicine, changed medicine and dominant medicine.
The supporting medicines were chosen by doctors’ knowledge and practice. Ruling medicine ingredients are used to elevate the effects on the cause, nature and symptoms of the disease, changed medicine ingredients are used to treat three humors’s disorders and dominant medicine ingredients are used to treat complications.
3.Clarification of ancient works written by foreign researchers on mongolian pharmacology and pharmaceutical formulation
Khastana M ; Gerelmaa B ; Chimedragchaa Ch ; Bold Sh
Mongolian Pharmacy and Pharmacology 2020;17(2):49-53
Abstract:
In recent years, the study of pharmacology and pharmaceutical formulation of traditional Mongolian medicine has been developing significantly. However, there are few research papers on Mongolian pharmacology and development of pharmaceutical formulation written by foreign researchers in ancient times. Therefore, the study was carried out to fill this “gap” and to clarify the ancient works of foreign researchers related to Mongolian pharmacology and development of pharmaceutical formulation.
Purpose of the study:
To chronologically identify the early works of foreign researchers on the study of pharmacology and pharmaceutical formulation of traditional Mongolian medicine.
Research method:
Hermeneutic approach, analysis of ancient textbook, and analysis and synthesis methods were used.
Conclusion
According to facts and eyewitnesses in the book of Zhouhou Beijifang (Emer- gency Prescriptions) by Ge Hong (261-341) of the Jin Dynasty, Jingui Yaolüe (Essential Prescriptions from the Golden Cabinet) by Chang Ji, the Northern Han Dynasty’s notes on “Xiongnu Doctors Carry Toxic Drugs”, Jāmiʿ al-Tawārīkh (Compendium of Chronicles) by Rashid-ad-Din, William de Rubruck’s “Journey to the Orient”, and book of Plano Carpini, an Italian tourist, the development of pharmacology and pharmaceuticals in traditional Mongolian medicine dates back to the Xiongnu period. Later, in the fourteenth century, it became an independent system of medical knowledge of many nations, as evidenced by the writings of Chinese, Persian, French, and Italian scholars as well as religious envoys.
4.A collection of Chinese medicinal raw materials and prescriptions in Zorigt wang’s “Mthong ba dga’ byad” sutra and their explanations
Khastana M ; Baolidao ; Tsetsegmaa S ; Bold Sh
Mongolian Pharmacy and Pharmacology 2020;17(2):54-58
Abstract:
In addition to citing from the old medical scriptures by Indian, Tibetan, and Mongolian medical scholars, “Mthong ba dga’ byad” by Jigmeddanzanjamts, also contains a number of prescriptions of Chinese medicine that were widely used in Chinese medical practice at that time. Therefore, crude drugs and prescriptions of Chinese medicine in this book has a great significance, but there are few studies done in the last decades.
Purpose:
To make selection of Chinese herbal medicines and recipes from the book “Mthong ba dga’ byad” by Jigmeddanzanjamts and explain them.
Research methods:
Research methods in ancient textbook, check list, analysis and synthesis methods were used.
Conclusion
It was clarified that in the book “Mthong ba dga’ byad” by Jigmeddanzanjamts there are 44 names of herbal medicines and prescriptions of Chinese origin, and some prescriptions are explained. According to these herbal medicines and prescriptions, Mongolian doctors and maarambas used not only Indian Ayurvedic and Tibetan medicines, but also Chinese medicines and prescriptions in their medical care.
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