1.Results of determining the content of some biologically active substances in compound herbal extract
Azzaya N ; Khandmaa D ; Naranchimeg E ; Batdorj D ; Khaliunsarnai B ; Badamtsetseg S ; Enkhsaikhan L ; Lkhaasuren R ; Khurelbaatar L ; Chimidtseren S
Mongolian Journal of Health Sciences 2025;85(1):85-90
Background:
Medicinal herbs have been used in traditional medicine to treat systemic inflammatory disease for many
years. For instance, Rhodiola rosea L extracts were used to enhance behavioural stresses for improving fatigue and
depression. Gallic acid, found in Rhodiola rosea L and Rhodiola quidrifida is, a natural polyphenol, exhibits multiple
therapeutic activities, including anti-inflammatory, anti-cancer, antioxidant, and anti-angiogenic effects. Saposhnikovia
divaricate (its ethanol extract mainly) notified to support function of musculoskeletal tissue and to enhance tissue regeneration by its anti-inflammatory effect. The Salsola laricifolia L has been studied for its strong antioxidant activity, improve
immune function, boost energy, and exhibit anti-inflammatory effects. This study allowed us to screen anti-inflammatory
effects of medicinal plants and future therapeutic possibility.
Aim:
To study the content of phenolic compounds (gallic acid) in the composition of complex products of plants widely
used in Mongolian traditional medicine, which have been found to have biological activity of the extracts
Materials and Methods:
The herbal extract was extracted from Rhodiola rosea L, Saposhnikovia divaricata (Tuscz)
Schischk, Rhodiola quidrifida Pall.Fisch, Salsola laricifolia Turcz.ex Litv in laboratory of the Drug Research Institute of
Monos Group, Mongolia.
We used solvents for HPLC grade was used to identify the bioactive components that Gallic acid in the compound plant
extract.
:
Results: The bioactive compounds in each of the Rhodiola rosea L, Rhodiola quadrifida Pall.Fisch and four medicinal
plant extracts were identified using HPLC, confirming the presence of Gallic acid.
Conclusion
Our research results showed that the quantitative content of Gallic acid in the composite plant extract was
high, at 1.02%.
2.Study on Students’ Eating Behavior and Some Influencing Factors
Zolzaya B ; Altanchimeg D ; Ser-Od KH ; Khandmaa S ; Darambazar G
Mongolian Journal of Health Sciences 2025;85(1):96-101
Backround:
The university period is a unique phase in students’ lives, often marked by independent living, changes in
lifestyle, diet, sleep patterns, increased psychological stress, and the development of unhealthy behaviors. Among students, particularly those studying in the medical field, research on dietary habits and influencing factors is scarce in our
country, which serves as the rationale for this study.
Aim:
The aim of this study is to investigate the dietary habits of medical students and the factors influencing them, including sleep, impulsivity, depression, anxiety, and stress.
Materials and Methods:
A cross-sectional study was conducted among 358 students from years 1 to 6 across 7 schools of
the Mongolian National University of Medical Sciences (MNUMS). Data were collected using internationally standardized and validated questionnaires, including the Three-Factor Eating Questionnaire Revised-18 (TFEQ-R18), the Short
UPPS-P Impulsive Behavior Scale-20 (SUPPS-P-20), the Depression, Anxiety, and Stress Scale-21 (DASS-21), and the
Pittsburgh Sleep Quality Index (PSQI). Statistical analysis was performed using SPSS 25.0.
Results:
In terms of eating behavior, uncontrolled eating (UE) and cognitive restraint (CR) were similar between male
and female students, while emotional eating (EE) was more prevalent among male students. Students’ eating behaviors
were associated with body mass index (BMI). As BMI increased, levels of depression, anxiety, and stress also tended to
rise. Sensation-seeking and positive urgency were higher among female students. Overall, 83.5% of students had poor
sleep quality, which contributed to increased depression, anxiety, stress, and impulsivity. Psychological burden and impulsivity were independent of the field of study but decreased as students progressed through their academic years, while
sleep quality improved.
Conclusion
The dietary habits of medical students were similar across genders but varied by academic year and field
of study. Poor sleep quality, observed in 83.5% of students, was associated with increased depression, anxiety, stress,
and impulsivity. Psychological burden and impulsivity were unrelated to the field of study but decreased with advancing
academic years, alongside improved sleep quality. As BMI increased, cognitive restraint in eating behaviors decreased.
3.A study on the level of depression among cancer patients
Khandmaa G ; Tuul M ; Pagmadulam S ; Batchuluun P
Diagnosis 2025;113(2):29-34
The global average cancer incidence is 9.3 per 100,000 population, while this figure is 93.7, or 10 times higher, in our country. At the end of the 2023 report, 28,855 people were being monitored and treated for cancer under the supervision of the province's district oncologists. According to the 2022 statistics of the World Health Organization, about 10 million people die from this disease every year in the world. In Mongolia, the incidence and mortality rate of cancer have also increased rapidly in recent years, and as of 2021, it has become the second leading cause of death.
To determine the level of depression in cancer patients and study the relationship between some factors affecting it research methods and scope: The study was conducted using a single-point analytical research design, and data were collected from 95 cancer patients under the care of a family health center between February 10, 2025 and March 20, 2025 using the PHQ 9, 18 Sleep Disorders Questionnaires, and 15 General Information Questionnaires, a total of 42 questionnaires issued by the WHO for primary health care providers. 26.3% (25) of the study participants were male, and 73.7% (70) were female. Of the total study participants, 39 (41.1%) were not depressed, 25 (26.3%) had self-limiting depression, 15 (15.8%) had moderate depression, 3 (3.2%) had moderate to severe depression, and 13 (13.7%) had severe depression. The majority of cancer patients are depressed. Severe depression can make it difficult to perform simple social activities and may even lead to suicide, so psychiatric evaluation, diagnosis, and treatment are necessary.
4.The result of pharmacological studies on traditional medicine Chun-7
Davaasambuu T ; Munkh-Erdene R ; Batchimeg B ; Enkhzul T ; Tsedensodnom Ch ; Bayanmunkh A ; Khandmaa D ; Choijamts G ; Tsetsegmaa S ; Lkhagva L ; Khurelbaatar L
Mongolian Pharmacy and Pharmacology 2022;21(2):35-40
Abstract:
CHUN-7 a Mongolian traditional recipe consisting of 7 medicinal plants is described in the scripture named “༆༆ །།གཡུ་ཐོག་པའི་མཛད་པའི་རིམས སྲུང་ཁྱུ་ལྔ་རྒྱམ་ཏོན་གསལ་བ །།”. The ingredients including Caowu (Radix
Aconiti kusnezoffii, CW) and Glehniae Radix (GR) have the effects of suppressing pneumonia, viral pneumonia, relieving pain, stimulating the immune system and reducing fever. The present study was aimed to determine acute and chronic toxicity properties of traditional drug.
Materials and methods:
CHUN 7 traditional drug were prepared in the traditional medicine sector of the Drug research Institute of Monos group. All WISTAR rats were kept in the same feed, under 12 hours lighting and 12 hours darkness housing. The study of acute and chronic toxicity of CHUN-7 traditional drug was studied by using IP and oral administration were performed on ten WISTAR rats and continued for a total of 28 days with 102.9 mg / kg dose (calculated from human dose: 16.7 mg/kg) in accordance with the WHO General Guidelines for the Evaluation and Study of Traditional Medicine.
Results:
The result showed no structural changes in the internal organs according to tissue morphology when we administrated CHUN-7 traditional drug.
Conclusion
This study showed CHUN-7 traditional drug has no toxic effects to internal organs including liver, kidney, stomach, lungs and heart. Therefore, CHUN-7 traditional drug has potential to use orally without any toxicology.
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