Background: Dysregulation of inflammation underpins chronic cardiovascular, metabolic, neurodegenerative, and neoplastic conditions. Traditional medicine has long utilized medicinal plants to alleviate and treat systemic inflammation. Specifically, Rhodiola rosea L. and Rhodiola quadrifida (Pall.) Fisch. & C.A.Mey. possess anti-inflammatory, antitumor, antioxidant, and anti-angiogenic properties. Saposhnikovia divaricata (Turcz.) Schischk. has been shown to exert anti-inflammatory effects, support musculoskeletal function, and enhance tissue regeneration. Furthermore, Salsola laricifolia Litv. has been studied for its antioxidant, immunomodulatory, and anti-inflammatory activities. Although the individual anti-inflammatory, antioxidant, and antitumor activities of these plants are established, research evaluating the combined effect of their combined extract remains scarce, providing the rationale for this study. Aim: To evaluate the in vitro effects of a combined extract derived from these medicinal plants on the expression of selected pro-inflammatory cytokines. Materials and Methods: A dry combined extract consisting of Rhodiola rosea, Rhodiola quadrifida, Salsola laricifolia, and Saposhnikovia divaricata was prepared at the Chemistry and Technology Sector of the Institute of Pharmaceutical Research, Monos Group. An in vitro inflammation model was established using murine RAW264.7 macrophage-like cells stimulated with lipopolysaccharide (LPS, 100 ng/mL). Cell viability was assessed using the CCK-8 assay, while the output of pro-inflammatory cytokines TNF-α and IL-6 was measured via Enzyme-Linked Immunosorbent Assay (ELISA). Statistical analysis was performed using one-way ANOVA. Result: The combined plant extract demonstrated no cytotoxic effects on RAW264.7 cells across the tested concentration range. In LPS-stimulated RAW264.7 macrophages, the composite extract dose-dependently and significantly suppressed the production of the pro-inflammatory cytokines TNF-α (p<0.001) and IL-6 (p<0.0001). Conclusion 1. The combined extract of Saposhnikovia divaricata, Rhodiola rosea, Rhodiola quadrifida, and Salsola laricifolia exhibited no cytotoxicity in vitro within the range of 50–400 µg/mL. 2. The combined herbal extract significantly suppressed the production of pro-inflammatory cytokines TNF-α (p<0.01) and IL-6 (p<0.001) in LPS-induced RAW264.7 macrophages in a concentration-dependent manner.

The global average cancer incidence is 9.3 per 100,000 population, while this figure is 93.7, or 10 times higher, in our country. At the end of the 2023 report, 28,855 people were being monitored and treated for cancer under the supervision of the province's district oncologists. According to the 2022 statistics of the World Health Organization, about 10 million people die from this disease every year in the world. In Mongolia, the incidence and mortality rate of cancer have also increased rapidly in recent years, and as of 2021, it has become the second leading cause of death.
To determine the level of depression in cancer patients and study the relationship between some factors affecting it research methods and scope: The study was conducted using a single-point analytical research design, and data were collected from 95 cancer patients under the care of a family health center between February 10, 2025 and March 20, 2025 using the PHQ 9, 18 Sleep Disorders Questionnaires, and 15 General Information Questionnaires, a total of 42 questionnaires issued by the WHO for primary health care providers. 26.3% (25) of the study participants were male, and 73.7% (70) were female. Of the total study participants, 39 (41.1%) were not depressed, 25 (26.3%) had self-limiting depression, 15 (15.8%) had moderate depression, 3 (3.2%) had moderate to severe depression, and 13 (13.7%) had severe depression. The majority of cancer patients are depressed. Severe depression can make it difficult to perform simple social activities and may even lead to suicide, so psychiatric evaluation, diagnosis, and treatment are necessary.

Background: Medicinal herbs have been used in traditional medicine to treat systemic inflammatory disease for many years. For instance, Rhodiola rosea L extracts were used to enhance behavioural stresses for improving fatigue and depression. Gallic acid, found in Rhodiola rosea L and Rhodiola quidrifida is, a natural polyphenol, exhibits multiple therapeutic activities, including anti-inflammatory, anti-cancer, antioxidant, and anti-angiogenic effects. Saposhnikovia divaricate (its ethanol extract mainly) notified to support function of musculoskeletal tissue and to enhance tissue regeneration by its anti-inflammatory effect. The Salsola laricifolia L has been studied for its strong antioxidant activity, improve immune function, boost energy, and exhibit anti-inflammatory effects. This study allowed us to screen anti-inflammatory effects of medicinal plants and future therapeutic possibility. Aim: To study the content of phenolic compounds (gallic acid) in the composition of complex products of plants widely used in Mongolian traditional medicine, which have been found to have biological activity of the extracts Materials and Methods: The herbal extract was extracted from Rhodiola rosea L, Saposhnikovia divaricata (Tuscz) Schischk, Rhodiola quidrifida Pall.Fisch, Salsola laricifolia Turcz.ex Litv in laboratory of the Drug Research Institute of Monos Group, Mongolia. We used solvents for HPLC grade was used to identify the bioactive components that Gallic acid in the compound plant extract. : Results: The bioactive compounds in each of the Rhodiola rosea L, Rhodiola quadrifida Pall.Fisch and four medicinal plant extracts were identified using HPLC, confirming the presence of Gallic acid. Conclusion Our research results showed that the quantitative content of Gallic acid in the composite plant extract was high, at 1.02%.

Backround: The university period is a unique phase in students’ lives, often marked by independent living, changes in lifestyle, diet, sleep patterns, increased psychological stress, and the development of unhealthy behaviors. Among students, particularly those studying in the medical field, research on dietary habits and influencing factors is scarce in our country, which serves as the rationale for this study. Aim: The aim of this study is to investigate the dietary habits of medical students and the factors influencing them, including sleep, impulsivity, depression, anxiety, and stress. Materials and Methods: A cross-sectional study was conducted among 358 students from years 1 to 6 across 7 schools of the Mongolian National University of Medical Sciences (MNUMS). Data were collected using internationally standardized and validated questionnaires, including the Three-Factor Eating Questionnaire Revised-18 (TFEQ-R18), the Short UPPS-P Impulsive Behavior Scale-20 (SUPPS-P-20), the Depression, Anxiety, and Stress Scale-21 (DASS-21), and the Pittsburgh Sleep Quality Index (PSQI). Statistical analysis was performed using SPSS 25.0. Results: In terms of eating behavior, uncontrolled eating (UE) and cognitive restraint (CR) were similar between male and female students, while emotional eating (EE) was more prevalent among male students. Students’ eating behaviors were associated with body mass index (BMI). As BMI increased, levels of depression, anxiety, and stress also tended to rise. Sensation-seeking and positive urgency were higher among female students. Overall, 83.5% of students had poor sleep quality, which contributed to increased depression, anxiety, stress, and impulsivity. Psychological burden and impulsivity were independent of the field of study but decreased as students progressed through their academic years, while sleep quality improved. Conclusion The dietary habits of medical students were similar across genders but varied by academic year and field of study. Poor sleep quality, observed in 83.5% of students, was associated with increased depression, anxiety, stress, and impulsivity. Psychological burden and impulsivity were unrelated to the field of study but decreased with advancing academic years, alongside improved sleep quality. As BMI increased, cognitive restraint in eating behaviors decreased.

Abstract: CHUN-7 a Mongolian traditional recipe consisting of 7 medicinal plants is described in the scripture named “༆༆ །།གཡུ་ཐོག་པའི་མཛད་པའི་རིམས སྲུང་ཁྱུ་ལྔ་རྒྱམ་ཏོན་གསལ་བ །།”. The ingredients including Caowu (Radix Aconiti kusnezoffii, CW) and Glehniae Radix (GR) have the effects of suppressing pneumonia, viral pneumonia, relieving pain, stimulating the immune system and reducing fever. The present study was aimed to determine acute and chronic toxicity properties of traditional drug. Materials and methods: CHUN 7 traditional drug were prepared in the traditional medicine sector of the Drug research Institute of Monos group. All WISTAR rats were kept in the same feed, under 12 hours lighting and 12 hours darkness housing. The study of acute and chronic toxicity of CHUN-7 traditional drug was studied by using IP and oral administration were performed on ten WISTAR rats and continued for a total of 28 days with 102.9 mg / kg dose (calculated from human dose: 16.7 mg/kg) in accordance with the WHO General Guidelines for the Evaluation and Study of Traditional Medicine. Results: The result showed no structural changes in the internal organs according to tissue morphology when we administrated CHUN-7 traditional drug. Conclusion This study showed CHUN-7 traditional drug has no toxic effects to internal organs including liver, kidney, stomach, lungs and heart. Therefore, CHUN-7 traditional drug has potential to use orally without any toxicology.