MiRNA,as a class of short non-coding RNA molecules,plays an important role in the post-transcriptional regula-tion of gene expression.miRNAs regulate gene expression by targeting specific mRNA sequences,thereby affecting various cellular bio-logical behaviors,including proliferation,apoptosis,migration,and invasion.In recent years,it has been found that miRNA may play an important role in the occurrence and development of hepatocellular carcinoma.This article provides a review of the research progress on the association between miRNA and the occurrence and development of hepatocellular carcinoma.

Objective To analyze the research hotspots and frontier trends in the field of physical therapy for Parkinson's disease(PD)from 2014 to 2023.Methods Relevant literatures published from January,2014 to December,2023 were retrieved from the Web of Science Core Collection.CiteSpace 6.3.R1 was used to conduct bibliometric analysis,generating visual maps of coun-tries,institutions,keyword co-occurrence,burst terms,timelines and clustering,and they were summarized based on both visual results and literature content.Results A total of 400 articles were included.The United States had the highest publication volume,followed by China,Italy and Brazil,and the international collaboration was relatively active.Major contributing institutions included Northwestern University,Rush University,Karolinska Institutet and Universidade de S?o Paulo.Keyword co-oc-currence analysis showed that researches mainly focused on interventions such as exercise,postural control,aero-bic exercise and transcranial direct current stimulation.Burst detection analysis showed that keywords with high attention in recent years included motor symptoms,executive function,resistance training and noninvasive brain stimulation.The timeline map indicated a shift in research themes from early focus on electrical stimulation to in-tegrated interventions involving both motor and cognitive functions.Conclusion Over the past decade,researches on physical therapy for PD has shown steady growth,with increasing diver-sity in intervention strategies.There is a clear trend toward multidimensional integration and interdisciplinary col-laboration.Future studies should strengthen interventions targeting non-motor symptoms and promote the clinical application of new rehabilitation technologies.

Objective To analyze the research hotspots and frontier trends in the field of physical therapy for Parkinson's disease(PD)from 2014 to 2023.Methods Relevant literatures published from January,2014 to December,2023 were retrieved from the Web of Science Core Collection.CiteSpace 6.3.R1 was used to conduct bibliometric analysis,generating visual maps of coun-tries,institutions,keyword co-occurrence,burst terms,timelines and clustering,and they were summarized based on both visual results and literature content.Results A total of 400 articles were included.The United States had the highest publication volume,followed by China,Italy and Brazil,and the international collaboration was relatively active.Major contributing institutions included Northwestern University,Rush University,Karolinska Institutet and Universidade de S?o Paulo.Keyword co-oc-currence analysis showed that researches mainly focused on interventions such as exercise,postural control,aero-bic exercise and transcranial direct current stimulation.Burst detection analysis showed that keywords with high attention in recent years included motor symptoms,executive function,resistance training and noninvasive brain stimulation.The timeline map indicated a shift in research themes from early focus on electrical stimulation to in-tegrated interventions involving both motor and cognitive functions.Conclusion Over the past decade,researches on physical therapy for PD has shown steady growth,with increasing diver-sity in intervention strategies.There is a clear trend toward multidimensional integration and interdisciplinary col-laboration.Future studies should strengthen interventions targeting non-motor symptoms and promote the clinical application of new rehabilitation technologies.

Objective To explore the feasibility and efficacy of single-balloon enteroscope in the diagnosis and treatment of calculous small intestinal obstruction.Methods A retrospective analysis was performed on the clinical data of 16 patients who underwent endoscopic enterolith removal for small intestinal obstruction from July 2013 to December 2023.The outcomes of stone removal and therapeutic efficacy were evaluated.Results All the 16 patients successfully underwent single-balloon enteroscope.Among them,15 cases achieved successful stone extraction,while 1 case failed due to an oversized stone that could not pass through the pharyngoesophageal junction.The stone was subsequently pushed to the stomach and removed through surgical operation finally.Conclusion Single-balloon enteroscope has excellent efficacy in enterolith removal,with rapid postoperative recovery and less complications.It is worthy of widespread clinical application.

Objective To explore the feasibility and efficacy of single-balloon enteroscope in the diagnosis and treatment of calculous small intestinal obstruction.Methods A retrospective analysis was performed on the clinical data of 16 patients who underwent endoscopic enterolith removal for small intestinal obstruction from July 2013 to December 2023.The outcomes of stone removal and therapeutic efficacy were evaluated.Results All the 16 patients successfully underwent single-balloon enteroscope.Among them,15 cases achieved successful stone extraction,while 1 case failed due to an oversized stone that could not pass through the pharyngoesophageal junction.The stone was subsequently pushed to the stomach and removed through surgical operation finally.Conclusion Single-balloon enteroscope has excellent efficacy in enterolith removal,with rapid postoperative recovery and less complications.It is worthy of widespread clinical application.

MiRNA,as a class of short non-coding RNA molecules,plays an important role in the post-transcriptional regula-tion of gene expression.miRNAs regulate gene expression by targeting specific mRNA sequences,thereby affecting various cellular bio-logical behaviors,including proliferation,apoptosis,migration,and invasion.In recent years,it has been found that miRNA may play an important role in the occurrence and development of hepatocellular carcinoma.This article provides a review of the research progress on the association between miRNA and the occurrence and development of hepatocellular carcinoma.

Objective:To assess the effectiveness of the combined biological therapy and endoscopic balloon dilation (EBD) for preventing intestinal stricture recurrence in patients with Crohn disease, and to identify the risk factors for post-EBD stricture recurrence.Methods:This retrospective cohort study enrolled Crohn disease patients who underwent EBD with or without biological therapy at the Department of Gastroenterology, the First People's Hospital of Changzhou, from January 2016 to December 2023. The patients were divided into the biologics-EBD group and the EBD monotherapy group, and recurrence rates of intestinal stenosis between the groups were compared. The Kaplan-Meier method was employed to estimate the stricture-free survival, with intergroup differences assessed via log-rank test. The Cox proportional hazards regression model was utilized to perform a multivariate analysis of the survival data of the included cases for the independent risk factors for the recurrence of intestinal strictures after EBD in Crohn disease.Results:In accordance with the inclusion and exclusion criteria, a total of 47 cases were ultimately included in the study, with 29 cases in the biologics-EBD group and 18 cases in the EBD monotherapy group. The baseline data of the two groups were comparable. Stricture recurrence occurred in 6/29 (20.7%) biologics-EBD patients versus 10/18 (55.6%) EBD monotherapy patients. Kaplan-Meier curves demonstrated superior cumulative stricture-free survival in the biologics-EBD cohort ( P=0.014). Cox proportional hazards regression model confirmed elevated recurrence risk with EBD monotherapy ( HR=5.360, 95% CI: 1.340-21.449, P=0.018) and small intestinal strictures ( HR=7.746, 95% CI: 1.908-31.446, P=0.004). Conclusion:The combination of biologics with EBD for the treatment of intestinal strictures in Crohn disease can effectively prevent the recurrence of intestinal strictures. Regarding small intestinal strictures in Crohn disease, it is suggested to combine biologics for treatment to prevent the high recurrence rate of strictures.

Objective:To assess the effectiveness of the combined biological therapy and endoscopic balloon dilation (EBD) for preventing intestinal stricture recurrence in patients with Crohn disease, and to identify the risk factors for post-EBD stricture recurrence.Methods:This retrospective cohort study enrolled Crohn disease patients who underwent EBD with or without biological therapy at the Department of Gastroenterology, the First People's Hospital of Changzhou, from January 2016 to December 2023. The patients were divided into the biologics-EBD group and the EBD monotherapy group, and recurrence rates of intestinal stenosis between the groups were compared. The Kaplan-Meier method was employed to estimate the stricture-free survival, with intergroup differences assessed via log-rank test. The Cox proportional hazards regression model was utilized to perform a multivariate analysis of the survival data of the included cases for the independent risk factors for the recurrence of intestinal strictures after EBD in Crohn disease.Results:In accordance with the inclusion and exclusion criteria, a total of 47 cases were ultimately included in the study, with 29 cases in the biologics-EBD group and 18 cases in the EBD monotherapy group. The baseline data of the two groups were comparable. Stricture recurrence occurred in 6/29 (20.7%) biologics-EBD patients versus 10/18 (55.6%) EBD monotherapy patients. Kaplan-Meier curves demonstrated superior cumulative stricture-free survival in the biologics-EBD cohort ( P=0.014). Cox proportional hazards regression model confirmed elevated recurrence risk with EBD monotherapy ( HR=5.360, 95% CI: 1.340-21.449, P=0.018) and small intestinal strictures ( HR=7.746, 95% CI: 1.908-31.446, P=0.004). Conclusion:The combination of biologics with EBD for the treatment of intestinal strictures in Crohn disease can effectively prevent the recurrence of intestinal strictures. Regarding small intestinal strictures in Crohn disease, it is suggested to combine biologics for treatment to prevent the high recurrence rate of strictures.

Objective:To analyze the research status and hotspots in the field of post endoscopic retrograde cholangiopancreatography pancreatitis (PEP) based on the Web of Science database.Methods:The Web of Science database was searched by using the subject term "post-ERCP pancreatitis," with language limited to English and document types limited to "article" and "review." The time span was from January 1, 2000 to December 31, 2023. VOSviewer and CiteSpace software were used to analyze the publication year, country, institution, author, journal source, and keywords of the included literature, and to create corresponding visualization knowledge maps.Results:A total of 1 197 documents were included, with an overall steady upward trend on the annual volume of PEP publications. The top three countries in terms of PEP publication volume were the United States (334 articles, 31.19%), China (205 articles, 19.14%), and Japan (180 articles, 16.81%). The top three countries in terms of citation frequency were the United States (17 088 times), Italy (3 936 times), and Japan (3 615 times). The top three institutions in terms of publication volume were Indiana University (34 articles), Mayo Clinic (32 articles), and the University of Pittsburgh (23 articles). The top three institutions in terms of citation frequency were Indiana University (3 524 times), Mayo Clinic (2 675 times), and the University of Minnesota (1 951 times). Among Chinese institutions, Shanghai Jiao Tong University ranked the 4th in publication volume (22 articles), and Nanchang University ranked the 10th (17 articles), but their citation frequencies were relatively low (Shanghai Jiao Tong University 233 times, Nanchang University 108 times). The author with the highest publication volume in the PEP field was Sherman S (32 articles), and the author with the highest co-citation frequency ranking was Cotton PB (769 times). The top three journals in terms of publication volume were Gastrointestinal Endoscopy, Endoscopy, and World Journal of Gastroenterology. The keyword network map revealed distinct clusters covering themes such as the pathogenesis, risk factors, pharmacological prevention, procedural prevention, and management of PEP. Burst keyword analysis showed that the keyword with the longest emergence time was "Oddi dysfunction" and the keyword with the highest burst strength was "rectal indomethacin".Conclusions:Since the beginning of this century, PEP research has developed rapidly, and China has a certain academic influence on PEP internationally. Research on risk factors and preventive measures remains a research hotspot in the field of PEP.

Objective:To investigate the level of functional fitness of elderly hypertensive patients in the community and to analyze its influencing factors.Methods:A cross-sectional survey was used from November 2021 to September 2022, questionnaire survey and Senior Functional Fitness Test (SFT) were conducted on 189 elderly hypertensive patients in the community by convenience sampling method, multiple linear regression was used to analyze the influencing factors of SFT in elderly hypertensive patients in the community.Results:Totally 189 cases of community-aged hypertensive patients completed the investigation, 88 cases were male and 101 were female. The total SFT score of community-aged hypertensive patients was (58.61 ± 16.07). Single factor analysis showed that there were significant differences in SFT scores among patients with different gender, age and education ( t=-2.57, F=6.24, 7.54, all P<0.05). Multifactorial analysis revealed that age ( t=-5.55), gender ( t=2.63), and literacy ( t=5.69) were influential factors in the total SFT scores of community-dwelling elderly hypertensive patients (all P<0.05). Conclusions:Age, gender, and literacy level are the main factors affecting the total SFT scores of elderly hypertensive patients in the community, and community caregivers should pay close attention to the above elderly hypertensive population.