Acute lateral ankle sprain (ALAS) is one of the most common sport injuries, with high incidence, recurrence and disability rates. Currently, exercise rehabilitation-based non-surgical treatment is the primary management approach for ALAS. However, there remain improper practices such as excessive immobilization or uncontrolled activity, which contribute to recurrent sprains and chronic ankle instability, significantly impairing patients′ athletic function and quality of life. To standardize the non-surgical management of ALAS, improve the cure rates, and reduce the recurrence and disability rates, Chinese Sports Rehabilitation Medicine Training Project of Chinese Medical Association, Foot and Ankle Basics and Orthopedics Group, Orthopedic Branch of Chinese Medical Doctor Association, and Sports Medicine Branch of Jiangsu Medical Association organized relevant experts to formulate Expert consensus on non-surgical treatment for acute lateral ankle sprain ( version 2025), following the principles of scientific vigor, practicality, and innovation. Thirteen recommendations were proposed for standardized treatment protocols across different healing phases, aiming to provide references for standard management of ALAS and improve the therapeutic outcomes.

Objective To explore the therapeutic effect of doubling the first dose of batroxobin in the treatment of sudden sensorineural hearing loss with reduced frequency.Methods A total of 96 patients diagnosed with sudden sensorineural hearing loss,who received treatment at the Department of Otolaryngology at the Second Affiliated Hospital of Guizhou Medical University between August 2022 and October 2024,were included in the study.Using the random number table method,the patients were assigned to two groups,an observation group and a control group,each comprising 48 cases.The control group was treated with Ginkgo biloba extract,methylpred-nisolone tablets,and a first dose of 10 BU of batroxobin,while the observation group was treated with Ginkgo biloba extract,methylprednisolone tablets,and a first dose of 20 BU of batroxobin.After one cycle of treatment,compare the pure tone hearing threshold,hemorheological indicators,coagulation function indicators,efficacy,and adverse reactions between the two groups.Follow up for 6 months and record the recurrence outcome.Results After treatment,the pure tone hearing threshold of both groups decreased,and the observation group was lower than the control group(P<0.05).After treatment,the effective rates of the observation group and the control group were 77.08%and 54.17%,respectively,and the whole blood low shear viscosity was(18.27±1.63)(20.29±1.41)mPa·s,the whole blood shear viscosity was(5.58±0.64),(6.01±0.69)mPa·s,the whole blood high shear viscosity is(4.26±0.38),(4.54±0.31)mPa·s,the plasma viscosity is(1.52±0.26),(1.71±0.34)mPa·s,the red blood cell aggregation index is(0.60±0.21),(0.52±0.17),the red blood cell deformation index was(5.73±0.61),(6.20±0.64),and the fibrinogen(FIB)is(0.72±0.18).0.95±0.13)g/L,thrombin time(TT)were(23.51±2.08)and(21.76±2.13)s,prothrombin time(PT)were(12.71±0.63)and(12.05±0.65)s,respectively,and activated partial thromboplastin time(APTT)were(28.32±3.07)and(29.51±2.24)s,respectively,with the observation group showing more significant changes(P<0.05).The recurrence rate of the observation group was lower than that of the control group(P<0.05).Conclusion Doubling the first dose of batroxobin can help alleviate the symptoms of hearing impairment,improve inner ear microcirculation,and enhance treatment efficacy in patients with total frequency decline type sudden deafness.

Objective To explore the therapeutic effect of doubling the first dose of batroxobin in the treatment of sudden sensorineural hearing loss with reduced frequency.Methods A total of 96 patients diagnosed with sudden sensorineural hearing loss,who received treatment at the Department of Otolaryngology at the Second Affiliated Hospital of Guizhou Medical University between August 2022 and October 2024,were included in the study.Using the random number table method,the patients were assigned to two groups,an observation group and a control group,each comprising 48 cases.The control group was treated with Ginkgo biloba extract,methylpred-nisolone tablets,and a first dose of 10 BU of batroxobin,while the observation group was treated with Ginkgo biloba extract,methylprednisolone tablets,and a first dose of 20 BU of batroxobin.After one cycle of treatment,compare the pure tone hearing threshold,hemorheological indicators,coagulation function indicators,efficacy,and adverse reactions between the two groups.Follow up for 6 months and record the recurrence outcome.Results After treatment,the pure tone hearing threshold of both groups decreased,and the observation group was lower than the control group(P<0.05).After treatment,the effective rates of the observation group and the control group were 77.08%and 54.17%,respectively,and the whole blood low shear viscosity was(18.27±1.63)(20.29±1.41)mPa·s,the whole blood shear viscosity was(5.58±0.64),(6.01±0.69)mPa·s,the whole blood high shear viscosity is(4.26±0.38),(4.54±0.31)mPa·s,the plasma viscosity is(1.52±0.26),(1.71±0.34)mPa·s,the red blood cell aggregation index is(0.60±0.21),(0.52±0.17),the red blood cell deformation index was(5.73±0.61),(6.20±0.64),and the fibrinogen(FIB)is(0.72±0.18).0.95±0.13)g/L,thrombin time(TT)were(23.51±2.08)and(21.76±2.13)s,prothrombin time(PT)were(12.71±0.63)and(12.05±0.65)s,respectively,and activated partial thromboplastin time(APTT)were(28.32±3.07)and(29.51±2.24)s,respectively,with the observation group showing more significant changes(P<0.05).The recurrence rate of the observation group was lower than that of the control group(P<0.05).Conclusion Doubling the first dose of batroxobin can help alleviate the symptoms of hearing impairment,improve inner ear microcirculation,and enhance treatment efficacy in patients with total frequency decline type sudden deafness.

Acute lateral ankle sprain (ALAS) is one of the most common sport injuries, with high incidence, recurrence and disability rates. Currently, exercise rehabilitation-based non-surgical treatment is the primary management approach for ALAS. However, there remain improper practices such as excessive immobilization or uncontrolled activity, which contribute to recurrent sprains and chronic ankle instability, significantly impairing patients′ athletic function and quality of life. To standardize the non-surgical management of ALAS, improve the cure rates, and reduce the recurrence and disability rates, Chinese Sports Rehabilitation Medicine Training Project of Chinese Medical Association, Foot and Ankle Basics and Orthopedics Group, Orthopedic Branch of Chinese Medical Doctor Association, and Sports Medicine Branch of Jiangsu Medical Association organized relevant experts to formulate Expert consensus on non-surgical treatment for acute lateral ankle sprain ( version 2025), following the principles of scientific vigor, practicality, and innovation. Thirteen recommendations were proposed for standardized treatment protocols across different healing phases, aiming to provide references for standard management of ALAS and improve the therapeutic outcomes.

Objective To analyze the correlation between detection of influenza pathogenic subtypes and epidemic situation in Hefei City during the surveillance years of 2015-2021, and to provide references for developing influenza prevention and control strategies. Methods The relevant data of influenza-like illness (ILI) surveillance, influenza etiology, and outbreak/cluster outbreaks reported from influenza surveillance sentinel hospitals in Hefei City from 2015 to 2021 in the China Influenza Surveillance Information System were analyzed. The statistical analysis was carried out. Results A total of 3 332 553 outpatient and emergency visits in 2 sentinel hospitals were reported in Hefei City from 2015 to 2021, of which 139,082 were ILI cases, accounting for 4.17%. The monthly proportion ranged from 1.60% to 7.15%. A total of 14 663 ILI specimens were submitted for detection, the submission rate was 10.54%, and the positive rate of influenza virus detection was 11.30%. There was no correlation between the proportion of monthly influenza like cases and the detection rate (r_s=0.176, P=0.107). The composition ratio of each subtype of influenza virus varied greatly, showing diversified seasonality, and the epidemic strains changed constantly. The Victoria subtype (BV subtype) was dominant (40.21%). There was a moderate correlation between the positive rate of ILI in sentinel hospitals and the number of outbreaks per month (r_s=0.696, P=0.000). There was a strong correlation between the monthly number of outbreaks and the detection rate (r_ss=0.696, P=0.000). There was a strong correlation between influenza A virus H3 subtype and BV subtype (r_{s -H3}=0.686, P=0.030; r_{s -BV}=0.632, P=0.000). There was a moderate correlation between the new A1 subtype and B Yamagata subtype (r_{s -new A H1}=0.481, P=0.000 0; r_{s -BY}=0.515, P=0.000). Conclusion There are two epidemic peaks in spring and winter in Hefei. Influenza subtypes are diverse. The results of ILI etiology can predict the outbreaks of different subtypes of influenza. Prediction and surveillance should be used for influenza control and outbreak management in a timely manner.

Objective To investigate the effect of humidex combined with mean temperature and relative humidity on the incidence of bacillary dysentery in Hefei. Methods Daily counts of bacillary dysentery cases and weather data in Hefei were collected from January 1, 2006 to December 31, 2013. Then, the humidex was calculated from temperature and relative humidity. A Poisson generalized linear regression combined with distributed lag non-linear model was applied to analyze the relationship between humidex and the incidence of bacillary dysentery, after adjusting for long-term and seasonal trends, day of week and other weather confounders. Stratified analyses by gender, age and address were also conducted. Results The risk of bacillary dysentery increased with the rise of humidex. The adverse effect of high humidex (90 percentile of humidex) appeared in 2- days lag and it was the largest at 4-days lag (RR=1.063, 95%CI:1.037-1.090). Subgroup analyses indicated that all groups were affected by high humidex at lag 2-5 days. Conclusion High humidex could significantly increase the risk of bacillary dysentery, and the lagged effects were observed.

Objective To observe the effect of Boari bladder muscle flap surgery in nephron sparing surgery for patients with middle and lower ureteral carcinoma. Methods Totally 80 patients with middle and lower ureteral carcinoma underwent surgery in our hospital from March 2009 to March 2012 were selected and divided into the control group and the observation group,with 40 cases in each group. Patients of the control group were treated with ureteral carcinoma radical prostatectomy while patients of the observation group were treated with Boari bladder muscle flap surgery,and all of them were followed up for 3 years after operation. Observed the renal function,renal tumor markers and the level of inflammatory symptoms of the 2 groups before the operation and 3 months after the operation,and compared the long-term progno-sis of the 2 groups. Results There was no significant difference between the 2 groups in renal function index before operation. The level of BUN,Scr,blood urea and serum uric acid index in the 2 groups were all increased compared with those before operation,but the increase of the control group was significantly higher with statistically significant differences (P<0. 05). The tumor markers CA19-9, Survivin and in-flammatory marks WBC,NEC%,IL-6,hs-CRP had no significant difference before operation,and all the level of the 2 groups were decreased after operation,but there was still no difference between the 2 groups (P>0. 05). The survival rate 1 year,2 years and 3 years after operation also had no significant difference between the 2 groups (P>0. 05). Conclusion The use of Boari bladder muscle flap surgery in nephron sparing surgery for patients with middle and lower ureteral carcinoma can effectively maintain the renal function of patients without affecting the radical and long-term prognosis.

OBJECTIVETo study the biocompatibility of porous calcium phosphate ceramics nanocomposite.

METHODSThe biocompatibility was evaluated via experiments including the hemolysis test, hemopexis test, acute systemic toxicity test, pyrogen test, and intramuscular implant test, in which biphasic calcium phosphate nanocomposite (NanoBCP) presented as leaching solution, suspension or blocks of 5 mmx5 mmxl mm. Animals including New Zealand Rabbits, Kunming mice, SD rats were selected as the host.

RESULTSThe hemolysis of NanoBCP was 1.1% (<5%). Four coagulation index levels were within the normal range. In pyrogen test, the temperature of each experimental rat increased by 0.35, 0.40, 0.28 degrees C (<0.60 degrees C, in accordance with the pyrogen-free criterion for biomedical materials). No consequent death, dyspnoea, organ dysfunction, severe peritoneal irritation or ptosis was observed in acute systemic toxic test. Newly-formed fibrous tissue could be found after the implantation.

CONCLUSIONThe material possesses outstanding biocompatibility and degradability with no toxicity or irritation, contains no pyrogen, as well as better degradation properties than biphasic calcium phosphate.

Animals ; Biocompatible Materials ; Calcium Phosphates ; Ceramics ; Hydroxyapatites ; Mice ; Nanocomposites ; Prostheses and Implants ; Rabbits ; Rats ; Rats, Sprague-Dawley

OBJECTIVETo investigate the relationship between the stages of calcification of various teeth and cervical vertebral bone ages among children and adolescents in Chengdu.

METHODSThe study subjects consist of 256 children and adolescents in Chengdu with age ranging from 10 to 16 years. All panoramic radiographs and cephalometric radiographs were obtained. The relationship with the stages of chronological ages, calcification of various teeth and cervical vertebral bone ages were analyzed.

RESULTSThe Spearman rank correlation coefficient revealed highly significant relationships between cervical vertebral bone ages and chronological ages (r = 0.726, P < 0.01). Dental ages and chronological ages had medium relationship (r = 0.629, P < 0.01), also dental ages and cervical vertebral bone ages medium relationship (r = 0.668, P < 0.01).

CONCLUSIONCervical vertebral bone ages, chronological ages and dental calcification stages have correlation among children and adolescents in Chengdu. The cervical vertebral bone ages have high connection with chronological ages. Cervical vertebral bone age might be a better indicator in judging growth and development of children and adolescents during orthodontic treatment.

Adolescent ; Age Determination by Skeleton ; Cephalometry ; Child ; Female ; Humans ; Male ; Radiography, Panoramic ; Tooth

OBJECTIVE To investigate the antimicrobial resistances of Gram-negative bacilli isolated from patients with lower respiratory infection in intensive care unit(ICU),so as to provide reasonable selections for antibiotic in clinical treatment.METHODS The phlegm specimens from ICU inpatients with lower respiratory tract infection were collected from 2004 to 2007,and drug sensitivity test was performed according to NCCLS standards.RESULTS Gram-negative bacilli were accounted for 75.2% of total strains.The most predominant pathogens were Pseudomonas aeruginosa(42.7%),Acinetobacter baumannii(16.3%),Sternotrophomonas maltophilia(10.4%),Escherichia coli(10.0%),and Klebsiella pneumoniae(6.7%).The prevalence of ESBLs in E.coli and K.pneumoniae increased from 54.5% and 37.5 % in 2004 to 65.6 % and 52.7% in 2007.ESBLs non-producing strains showed lower resistance rates to the aminoglycosides,quinolones and the third and fourth generation cephalosporin than those of ESBLs producing strains.Nonfermentative Gram-negative bacilli were very highly resistant to most antimicrobial agents.CONCLUSIONS The drug resistance rates of Gram-negative bacilli of lower respiratory tract are serious.It is important to investigate the antimicrobial resistances of pathogenic bacteria and rationally use of antibiotics.