Objective:To explore the predictive value of serum fibroblast growth factor-21 (FGF-21), insulin-like growth factor-1 (IGF-1), and serum ferritin (SF) for maternal and infant outcomes in patients with pregnancy complicated by hypothyroidism.Methods:A total of 246 patients with pregnancy complicated by hypothyroidism who underwent prenatal examination at the Ankang Central Hospital from January 2021 to September 2024 were retrospectively selected as the observation group. Meanwhile, 100 healthy pregnant women who received prenatal examination in the hospital during the same period were enrolled as the control group. According to the maternal and infant outcomes, the observation group was divided into the adverse maternal and infant outcome group ( n=55) and the favorable maternal and infant outcome group ( n=191). Baseline data were compared among groups. Pearson correlation analysis was used to evaluate the correlations between FGF-21, IGF-1, SF and thyroid hormone levels. Univariate and multivariate analyses were applied to screen the influencing factors of maternal and infant outcomes in patients with pregnancy complicated by hypothyroidism. Receiver operating characteristic (ROC) curve was drawn to assess the predictive value of FGF-21, IGF-1, and SF for adverse maternal and infant outcomes in these patients. Results:The serum levels of FGF-21 and thyroid-stimulating hormone (TSH) in the observation group were higher than those in the control group (all P<0.05), while the levels of IGF-1, SF, free thyroxine (FT4), and free triiodothyronine (FT3) were lower (all P<0.05). Pearson correlation analysis showed that in patients with pregnancy complicated by hypothyroidism, FGF-21 was positively correlated with TSH and negatively correlated with FT4 and FT3 (all P<0.05); IGF-1 and SF were negatively correlated with TSH and positively correlated with FT4 and FT3 (all P<0.05). Univariate analysis indicated that FGF-21, IGF-1, SF, TSH, and FT4 were related to maternal and infant outcomes in patients with pregnancy complicated by hypothyroidism (all P<0.05). Multivariate logistic regression analysis revealed that FGF-21 was an independent risk factor for adverse maternal and infant outcomes, while IGF-1 and SF were protective factors (all P<0.05). ROC curve analysis showed that the area under the curve (AUC) of serum FGF-21, IGF-1, and SF alone for predicting adverse maternal and infant outcomes were 0.811, 0.738, and 0.837, with sensitivities of 84.1%, 81.3%, and 76.6%, respectively—all lower than the AUC (0.876) and sensitivity (93.5%) of combined prediction, with statistically significant differences (all P<0.05). Conclusions:FGF-21, IGF-1, and SF are independent influencing factors for maternal and infant outcomes in patients with pregnancy complicated by hypothyroidism, and have good predictive value for adverse maternal and infant outcomes.

Objective:To explore the predictive value of serum fibroblast growth factor-21 (FGF-21), insulin-like growth factor-1 (IGF-1), and serum ferritin (SF) for maternal and infant outcomes in patients with pregnancy complicated by hypothyroidism.Methods:A total of 246 patients with pregnancy complicated by hypothyroidism who underwent prenatal examination at the Ankang Central Hospital from January 2021 to September 2024 were retrospectively selected as the observation group. Meanwhile, 100 healthy pregnant women who received prenatal examination in the hospital during the same period were enrolled as the control group. According to the maternal and infant outcomes, the observation group was divided into the adverse maternal and infant outcome group ( n=55) and the favorable maternal and infant outcome group ( n=191). Baseline data were compared among groups. Pearson correlation analysis was used to evaluate the correlations between FGF-21, IGF-1, SF and thyroid hormone levels. Univariate and multivariate analyses were applied to screen the influencing factors of maternal and infant outcomes in patients with pregnancy complicated by hypothyroidism. Receiver operating characteristic (ROC) curve was drawn to assess the predictive value of FGF-21, IGF-1, and SF for adverse maternal and infant outcomes in these patients. Results:The serum levels of FGF-21 and thyroid-stimulating hormone (TSH) in the observation group were higher than those in the control group (all P<0.05), while the levels of IGF-1, SF, free thyroxine (FT4), and free triiodothyronine (FT3) were lower (all P<0.05). Pearson correlation analysis showed that in patients with pregnancy complicated by hypothyroidism, FGF-21 was positively correlated with TSH and negatively correlated with FT4 and FT3 (all P<0.05); IGF-1 and SF were negatively correlated with TSH and positively correlated with FT4 and FT3 (all P<0.05). Univariate analysis indicated that FGF-21, IGF-1, SF, TSH, and FT4 were related to maternal and infant outcomes in patients with pregnancy complicated by hypothyroidism (all P<0.05). Multivariate logistic regression analysis revealed that FGF-21 was an independent risk factor for adverse maternal and infant outcomes, while IGF-1 and SF were protective factors (all P<0.05). ROC curve analysis showed that the area under the curve (AUC) of serum FGF-21, IGF-1, and SF alone for predicting adverse maternal and infant outcomes were 0.811, 0.738, and 0.837, with sensitivities of 84.1%, 81.3%, and 76.6%, respectively—all lower than the AUC (0.876) and sensitivity (93.5%) of combined prediction, with statistically significant differences (all P<0.05). Conclusions:FGF-21, IGF-1, and SF are independent influencing factors for maternal and infant outcomes in patients with pregnancy complicated by hypothyroidism, and have good predictive value for adverse maternal and infant outcomes.

Healthy China action is a key to the Healthy China initiative. Promoting Healthy China is faced with such challenges as coordinating actions of the society at large, and reliance on individual incentives. To overcome these difficulties, the authors propose to adopt a concentrating-on-the-main-points approach. As proposed, the government should focus on the key points of the overall situation and uphold the Healthy China initiative, and base all the actions on individual health actions as the focus. Community health service centers are expected to manage individual health actions so as to cover the population of the country. In this view, the government should formulate the policy of initiating and managing individual health actions by community health service centers.

Maggot debridement therapy(MDT)and conventional therapy were applied to diabetic foot ulcers(DFUs)with Wagner 2-4 respectively. The results showed that the prognosis was better in MDT group than in conventional therapy group. The reduction of circumference, square and volume of DFUs, healing rate of DFUs, decrease in number of bacterial species, and cost of antibiotics were all improved in the former group. The results suggest that MDT offers a fresh and effective method in the treatment of DFUs.

Objective:To study the distributing characteristics of digestive malignancy in patients with type 2 diabetes mellitus.Methods:We reviewed the complete data of 201 dead patients with type 2 diabetes mellitus from 2000 to 2005,sifted those complicated by cancer and those by digestive malignancy,and then analyzed the distributing characteristics and morbidity of the tumor.Results:The patients(126 males and 75 females) died at the average age of(73.53?9.03) years.Of the total number,57 cases(44 males and 13 females) were complicated by cancer and 25(22 males and 3 females) by digestive malignancy,the latter constituting the largest proportion of the diabetic patients(12.44%),followed by malignancy of the blood system,the lung and the urinary system.The pancreas was involved in 4.48% of the cases,while the stomach,esophagus,gallbladder and other digestive organs in only 0.498% of them.Of all the patients,those complicated by pancreatic cancer ran a shortest disease course of about 3 years,while those with the colon involved a longest course of about 11 years.Conclusion:Patients with type 2 diabetes mellitus are liable to cancer,particularly to digestive malignancy,and males are more susceptible than females.The cancerous characteristics,including morbidity and disease course,vary in different digestive organs.