Heart rate is a crucial indicator of human health with significant physiological importance. Traditional contact methods for measuring heart rate, such as electrocardiograph or wristbands, may not always meet the need for convenient health monitoring. Remote photoplethysmography (rPPG) provides a non-contact method for measuring heart rate and other physiological indicators by analyzing blood volume pulse signals. This approach is non-invasive, does not require direct contact, and allows for long-term healthcare monitoring. Deep learning has emerged as a powerful tool for processing complex image and video data, and has been increasingly employed to extract heart rate signals remotely. This article reviewed the latest research advancements in rPPG-based heart rate measurement using deep learning, summarized available public datasets, and explored future research directions and potential advancements in non-contact heart rate measurement.
Humans ; Deep Learning ; Heart Rate/physiology* ; Photoplethysmography/methods* ; Video Recording ; Face ; Monitoring, Physiologic/methods* ; Signal Processing, Computer-Assisted

Foodborne pathogens are one of the major factors leading to food safety issues, causing harm to the national economy and people's livelihood. Achieving rapid detection of foodborne pathogens is currently a key strategy for preventing and controlling foodborne diseases. Antibodies naturally possess high specificity and sensitivity, serving as preferred tools for specific recognition of foodborne pathogens. We list the main methods for detecting foodborne pathogens, introduce the evolution and development of polyclonal antibodies, monoclonal antibodies, and genetically engineered antibodies, and review the application of different antibody technologies in the rapid detection of foodborne pathogens. Furthermore, we recognize that the combination of antibody technology and other foodborne pathogen detection methods is currently a reliable means to improve detection performance. Finally, we elaborate on the existing limitations of different antibodies and summarize the current research status and potential issues, aiming to provide a theoretical basis and practical ideas for the development of rapid detection of foodborne pathogens.
Foodborne Diseases/prevention & control* ; Food Microbiology ; Antibodies, Monoclonal/biosynthesis* ; Antibodies/immunology* ; Humans ; Food Contamination/analysis*

Humans ; Hypertension/diagnosis*

Humans ; China/epidemiology* ; Hypertension/therapy*

Humans ; Hypertension/diagnosis*

Humans ; China/epidemiology* ; Hypertension/therapy*

Autism spectrum disorder (ASD) are kind of developmental behavior disorders with the core symptoms of social communication disorders, stereotyped behavior and narrow interest.Genetic factors play an important role in the incidence of ASD.Ion channels are a pore-forming protein on biofilm.They allow certain types of ions to pass through, and help to establish the voltage difference between cytoplasmic membranes, acting as the basis of neuroelectrophysiology.Ion channel abnormalities are related to many diseases, including ASD.In this paper, several kinds of genes related to ASDs in ion channels were reviewed, and in order to provide new ideas in the pathogenesis.

Objective To discuss the clinical manifestations, laboratory indexes, imageological ex-amination results,endoscopic and histopathological features of eosinophilic gastroenteritis( EG) in children. Methods Thirty-three children with EG were collected with clinical manifestations,allergic history,labora-tory examination,endoscopic and histopathological features and treatments,who were hospitalized at depart-ment of pediatric gastroenterology of Shengjing Hospital of China Medical University between January 2012 and December 2017. Results The main clinical manifestations of EG were abdominal pain(75. 8％),vomi-ting(30. 3％)and diarrhea(21. 2％). The hemoglobin level decreased in 7 cases(21. 2％). The eosinophil count increased in 13 cases ( 39. 4％) . Total serum IgE elevated in 18 cases ( 54. 5％) , while 23 cases were positive in serum food or respiratory specific IgE. The fecal occult blood test showed positive in 7 cases (21. 2％). Among 28 children conducted with whole abdominal CT,there were 13 cases of pelvis fluid, 12 cases of enlarged lymph nodes and 4 cases of thickened intestinal wall. All 33 children went through the endoscopic examination,the main histological change were erythema-exudation(31 cases,93. 9％),mucosal hyperemia edema(5 cases,15. 2％) and hemorrhage(4 cases,12. 1％). The main pathological change was mucosal inflammation with a large number of eosinophil infiltration(≥20 per HPF) . Among the 33 cases,17 cases relieved through treatment of avoiding allergen, antacids, anti-allergic agents and leukotriene receptor antagonist,with 1 case recurrence. The other 16 cases relieved after treatment of glucocorticoid and the above therapy,with 3 cases recurrence. Conclusion The clinical manifestations of children with EG are various and lack of specificity. In terms of diagnosis,the elevated level of eosinophil count and total serum IgE,or posi-tive in serum food specific IgE may be taken as reference. The definite diagnosis is based on pathological examination (eosinophil infiltration≥20 per HPF). For treatment,avoiding allergen,antacids,anti-allergic agents and leukotriene receptor antagonist are effective in several children. Glucocorticoid can obtain satisfac-tory curative effect in the uneffective children.

Objective To investigate the effect of raloxifene on ERα, ERβ and MT-1a expression in renal tubular epithelial cells contaminated with cadmium chloride,for exploring the protective effect and action mechanism of raloxifene in renal injury induced by cadmium. Methods Renal tubule cells were isolated from kidneys of new born SD rats and purified by Percoll. The cells of the second generation were selected for experiment. The cells were divided into 3 groups:blank control group,cadmium chloride group and raloxifene group. After 4 h,cell viability was detected by MTT,and after 24 h,mRNA and protein expression levels of ERα, ERβ and MT-1a in renal tissues were determined by RT-PCR and immunohistochemistry technology,respectively. Results Compared with the blank control group,morphology of plenty cells were changed in cadmium chloride group,a number of cells were dead,and the survival rate was only 55.3%;at the same time,mRNA and protein expression levels of ERβ and MT-1a significantly increased (P<0.05). Compared with cadmium chloride group,only a small part of cells underwent morphological changes,and the survival rate was 88.6% in raloxifene group,and the mRNA and protein expression levels of ERβand MT-1a were significantly decreased ( P<0.05) . The expression of ERαshowed no significant difference among the three groups ( P>0.05) . Conclusion Raloxifene can bond with ERβcompetively,down-regulate MT-1a and decrease Cd-MT synthesis,so as to reduce cadmium-induced damage of renal tubular epithelial cells.

T-wave alternans (TWA) refers to a phenomenon appearing in the surface electrocardiograph (ECG) as a consistent fluctuation in morphology and amplitude of the T wave on an "every-other-beat" basis. Correlation method (CM) has a certain ability to detect the non-stationary TWA, but it is very sensitive to noise. In this paper we propose a modified correlation method to ensure a stable and accurate detection of non-stationary TWA. Compared to the CM, the method modifies the judge condition and uses the linear fitting to limit the noise to gain the ability of detecting of non-stationary TWA. Our simulation and clinical data assessment study demonstrates the improved performance of the proposed algorithm.
Algorithms ; Artifacts ; Computer Simulation ; Electrocardiography ; methods ; Humans ; Signal Processing, Computer-Assisted ; Wavelet Analysis