Obesity is a risk factor for various neurological diseases， and a comprehensive understanding of its harmful effects on the central nervous system is of great significance for the prevention and treatment of obesity-related neurological diseases. The blood-brain barrier （BBB） is a regulatory interface between blood and the brain tissue， which can prevent harmful substances from entering the brain while eliminating metabolic wastes from the brain tissue. It plays an important role in cerebral microenvironment homeostasis and physiological function. However， a large number of studies have shown that obesity can cause dysfunction of the BBB， directly or indirectly promoting the development and progression of various neurological diseases. This review systematically summarizes the latest research progress on the phenotypes and mechanisms of BBB dysfunction in obesity. From the aspects of altered BBB permeability， transport dysfunction， and neuroinflammation， we present the specific phenotypes of BBB dysfunction caused by obesity and regulatory mechanisms， and discuss the harmful effects of obesity on BBB function，aiming to provide theoretical guidance for relevant basic research and clinical practice.
Obesity