Objective To make a retrospective investigation on the diagnosis and treatment of the chronic heart failure ( CHF) among hospitalized veteran cadres , so as to provide scientific evidence for the development of health protection policies against the disease.Methods Totally, the medical records of 201 veteran cadres admitted into our hospital for treatment of CHF from 2006-2015 were collected , and then the causes , inducing factors , diagnosis and treatment of the disorder were analyzed statistically .Results The sequence of the causes of CHF was:coronary heart disease (36.8%), hypertensive heart disease (31.3%), diabetic cardiomyop-athy (12.9%), chronic pulmonary heart disease (10.4%) and other factors (9.5%).The sequence of the inducing factors was:in-fection (28.4%), arrhythmia (23.4%), poor treatment compliance (17.9%), myocardial ischemia (13.9%), poor control of blood pressure (9.9%), and other factors (6.5%).The level of NT-proBNP for the patients of the 86-95 age group was significantly high-er than that of the 76-85 age group, and the NT-proBNP level of the 76-85 age group was significantly higher than that of the 66-75 age group.The level of LVEF in the 86-95 age group was significantly higher than that of the 76-85 age group, and the level of LVEF in the 76-85 age group was significantly lower than that of the 66-75 age group .The medication of digitalis , ACEI/ARB, beta blockers and spironolactone drugs accounted for 50.2%, 49.3%, 47.8% and 45.8% respectively.Conclusion With regard to the prevention and treatment of CHF in the veteran cadres , special attention should be paid to the control of the pathogenic causes and indu -cing factors, the standardization of treatment , as well as comprehensive management of the disorder outside hospital .

BACKGROUND: Inhaled glucocorticoids(IGC) are powerful anti_inflammatory agents used in the treatment of asthma. But it is still uncertain whether long-term use of the IGC affects bone metabolism in asthmatic patients, especially women.OBJECTIVE: To investigate if the prolonged treatment with IGC to Chinese asthmatic woman has a detrimental effect on bone mass and metabolism.DESIGN: A matched controlled study based on the patients SETTING:Clinical Laboratory and the Department of Respiratory Medicine, First Affiliated Hospital, Nanjing Medical University.PARTICIPANTS: From February 1998 to February 2002, forty female Chinese patients with bronchial asthma, regularly followed up at our outpatient clinic, all in the Nanjing area, none of them having a history of chronic systemic GC use, agreed to take part in the study, were selected and divided into two groups: therapeutic group (IGC group): 20 asthmatic women, aged 18-63 years, 5 menopausals, received IGC therapy regularly for at least 5 months; Control group: 20 asthmatic women, aged 18-60 years, 5 menopausals, never received IGC received conventional bronchodilators . They were matched individually for sex, age and menopausal status.METHODS: Bone mineral density (BMD) at the lumbar spine (2-4),femoral neck, trochanter, ward's triangle and total body of femur were measured by dual energy X-ray absorptiometry, BMD were expressed as a absolute value and a T score considered as a SD from peak bone mass respectively. Meanwhile, BMD was also expressed as a percentage (%), which was defined by comparing the BMD absolute value of subjects and BMD normal value of isosexual age cohorts. Osteocalcin and some other markers of bone metabolism were measured by radio immunoassay in two groups.daily dose and accumulative total dose of IGC and BMD in the IGC group.RESULTS: There were no significant difference between two groups in BMD and T score (including the lumbar spine (2-4), femoral neck,trochanter, ward' s triangle and total body of femur) (P ＞ 0.05). There were also no significant correlation between daily dose of IGC and BMD of above 5 parts in the IGC group (r=-0.325 to -0.1102, P ＞ 0.05). But,there were significantly negative correlation between the accumulative total dose of IGC and BMD at lumbar spine2-4,femoral neck and ward's triangle(r=-0.495 ,-0.517,-0.531 ,P ＜ 0.05).There were no significant correlation between the accumulative total dose of IGC and T score of above 5 parts in the IGC group (r=0.443to 0.295 ,P ＞ 0.05). There was negative correlation between the age and the BMD at ward's triangle in the IGC group(r=-0.506,P ＜ 0.05). However ,BMD at 5 locus were not correlated with the age in control group (r=-0.079 to 0.326, P ＞ 0.05).Osteocalcin and some other markers of bone metabolism were no significant difference between two groups (P ＞ 0.05).CONCLUSION: The data suggests that there is no significant influence of IGC on bone mineral density and bone metabolism in asthmatic women,but if continuing exposures to high doses over many years,there may be a detrimental effect on bone mass and metabolism in women, especially elder or postmenopausal asthmatic women treated with IGC who may be more susceptible to any bone mineral loss caused by IGC.