1.The correlation between quality of life (QOL) and medication adherence to antihypertensive medications among middle-aged Filipino adults.
Aiella Antonia B. Recto ; Alexandria H. Requierme ; Katrina Nicole D. Requizo ; Armando Miguel I. Reyes ; Dean Adrian G. Reyes ; John Andrew N. Reyes ; Marcellus Francis L. Ramirez
Journal of Medicine University of Santo Tomas 2026;10(1):1837-1847
INTRODUCTION
Hypertension is a serious public health issue that puts individuals at risk for various morbidity and mortality indicators. One of the most crucial factors in managing blood pressure and preventing complications is medication adherence which is linked to several determinants. This study explored the correlation between medication adherence among middle-aged hypertensive adults and the different domains of quality of life (QOL), which includes physical, psychological, social relationship and environment.
METHODSThis cross-sectional study involved 96 Filipino residents of Brgy. San Jose, Navotas City aged 35 to 65 years old diagnosed with hypertension and prescribed anti-hypertensive medications. Pearson’s correlation coefficient was used to calculate the correlation between different domains of QOL as well as the overall QOL score.
RESULTSResults revealed a statistically significant but weak positive correlation between overall QOL and medication adherence (r = 0.336, p<0.001). Among the QOL domains, environmental domain had the strongest correlation with adherence (r = 0.446, p = 0.00), followed by physical health (r = 0.443, p = 0.01) and psychological well-being (r = 0.382, p = 0.01). The social relationship domain showed negligible correlation (r = 0.163, p = 0.4).
CONCLUSIONThe study demonstrates that while medication adherence is modestly associated with better perceived QOL, especially in physical, psychological and environmental aspects, other factors likely influence both outcomes. These findings highlight the need for holistic, community-based interventions that address not only medication adherence but also environmental and psychosocial barriers to care in managing hypertension.
Human ; Adult: 25-44 Yrs Old ; Middle Aged: 45-64 Yrs Old ; Aged: 65-79 Yrs Old ; Quality Of Life ; Public Health ; Medication Adherence ; Antihypertensive Agents ; Blood Pressure ; Interpersonal Relations
2.Translation and validation of the health-related quality of life in stroke patients - 26 (HRQoLISP-26) scale into Filipino for Filipino adult stroke Patients.
Shanelle Katrina N. TAN ; Portia Margarita D. SIMSUANGCO ; Fatima Mae S. SINGSON ; Joselle T. SINSON ; Celina Therese R. SOLOMON ; Arnold Christopher P. SORIANO ; Stephen Lorenzo P. SULAY ; Mikhael Thaddeus S. SUPE ; Rafael Alfonso S. SYFU ; Althea Jannary C. TALENS ; Ian Cedric D. TAN ; Jan Tyrone CABRERA ; Wennielyn F. FAJILAN ; Elenita MENDOZA ; John Dale TROGO
Journal of Medicine University of Santo Tomas 2026;10(1):1895-1903
INRODUCTION
Stroke is one of the top five leading causes of disability in the Philippines. It has a significant impact on the quality of life (QoL) of patients, particularly in the functional and psycho-emotional aspects. Thus, it is important to understand the health-related quality of life in stroke patients (HRQoLISP), which focuses on the clinical impact of the disease and disability. The assessment of a stroke patient’s QoL is prognostically significant as it can predict a patient’s treatment success and survival.
OBJECTIVEThis study aims to translate the HRQoLISP-26 into Filipino and assess its content validity for Filipino adult stroke patients.
METHODOLOGYThe HRQoLISP-26 was translated into Filipino using a forward translation protocol and an expert analyzed the forward translation. Selected expert committee members reviewed the first version to assess for content validity and the questionnaire was modified accordingly. The content validity index (CVI) was used for content validity.
RESULTSMajority of the revisions made were done to improve the semantic and grammatical accuracy of items in the Filipino version of the HRQoLISP-26. Only a few items had no revisions implemented. No revisions were done in the final version of the translated questionnaire as each item had a CVI of 1 indicating that it has good content validity.
CONCLUSIONThe Filipino translated HRQoLISP-26 questionnaire is a validated questionnaire that allows assessment of a stroke survivor’s QoL.
Quality Of Life ; Patients ; Life ; Health ; Adult ; Stroke
3.Quality of care among patients with acute heart failure at the emergency room and adherence of physicians at the University of the Philippines – Philippine General Hospital to the division of cardiovascular medicine – heart failure pathway:A retrospective cohort study.
Mark John D. Sabando ; Felix Eduardo R. Punzalan ; Frances Dominique V. Ho ; Tam Adrian P. Aya-ay ; Kevin Paul Da. Enriquez ; Marie Kirk A. Maramara ; Ronald Allan B. Roderos ; Lauren Kay M. Evangelista
Acta Medica Philippina 2026;60(2):22-32
OBJECTIVES
Clinical pathways (CPs) ensure adherence to heart failure (HF) management guidelines. To optimize quality care in a low resource setting, an evidence-based care pathway for the management of acute HF was implemented at the emergency department (ED) of the Philippine General Hospital (PGH), the designated national tertiary hospital and referral center. This study aimed to describe the characteristics of adults with acute HF admitted at the ED and evaluate the quality of care they received, measured using physician adherence to the hospital’s acute heart failure CP.
METHODSThis was a retrospective, descriptive cohort study. We reviewed the inpatient charts of all adult patients with acute HF admitted to the ED of the PGH and referred to the Division of Cardiovascular Medicine between December 1, 2022 and May 31, 2023. Quality of care was assessed based on adherence to quality indicators adapted from routine and conditional order sets detailed in the pathway. Descriptive statistics was utilized to describe patient characteristics, quality of care, and outcomes.
RESULTSTwo hundred thirty-six (236) patients were included, with a mean age of 51.8 years. Majority were male (53.4%); hypertension (61.4%) and ischemic heart disease (53.8%) were the most common comorbidities, and infection the most common precipitant of decompensation (60.6%). There were optimal adherence rates to routine orders, which included referrals to Internal Medicine and Cardiology, baseline vital signs monitoring, fluid intake and output monitoring, chest radiograph, complete blood count, blood urea nitrogen, sodium, potassium, prothrombin time, partial thromboplastin time, arterial blood gas, urinalysis, and N-terminal pro b-type natriuretic peptide. Conditional orders, such as oxygen support, focused echocardiography, thyroid - stimulating hormone, and the use of vasopressors, diuretics, and venous thromboembolism prophylactic agents, were optimally performed when warranted. However, we noted suboptimal adherence to certain resource-intensive conditional orders, such as hourly monitoring of urine output (61.4%), hooking to cardiac monitor (53.8%), and performance of 12-lead ECG within 10 minutes (56.8%). Further, only 43.9% of patients were referred to the intensive care unit. Troponin I, calcium, magnesium, and albumin were ordered in excess.
CONCLUSIONOverall adherence rate of physicians to the hospital’s Acute Heart Failure Pathway was satisfactory. Work is needed to improve adherence to hourly urine output monitoring, consistent hooking to cardiac monitor, and timely performance of 12-lead ECG – an effort that begins with expanding in-hospital diagnostic equipment and human resource supply. We recommend continuous pathway implementation with periodic evaluation and stakeholder feedback to further improve quality of care.
Human ; Male ; Female ; Middle Aged: 45-64 Yrs Old ; Adult ; Albumins ; Blood ; Blood Urea Nitrogen ; Calcium ; Cardiology ; Chart ; Charts ; Cohort Studies ; Critical Care ; Critical Pathways ; Diagnostic Equipment ; Disease ; Diuretics ; Echocardiography ; Electrocardiography ; Emergencies ; Emergency Service, Hospital ; Equipment And Supplies ; Evaluation Studies As Topic ; Feedback ; Heart ; Heart Diseases ; Heart Failure ; Hormones ; Hospitals ; Hospitals, General ; Humans ; Hypertension ; Indicators And Reagents ; Infection ; Infections ; Inpatients ; Intensive Care Units ; Internal Medicine ; Lead ; Magnesium ; Male ; Medicine ; Myocardial Ischemia ; Natriuretic Peptide, Brain ; Natriuretic Peptides ; Nitrogen ; Overall ; Oxygen ; Partial Thromboplastin Time ; Patients ; Peptides ; Philippines ; Physicians ; Potassium ; Prothrombin ; Prothrombin Time ; Quality Of Health Care ; Referral And Consultation ; Sodium ; Statistics ; Tertiary Care Centers ; Thorax ; Thromboembolism ; Thromboplastin ; Thyroid Gland ; Time ; Troponin ; Troponin I ; Universities ; Urea ; Urinalysis ; Urine ; Venous Thromboembolism ; Vital Signs ; Work ; Workforce
4.Against the storm: Salvaging refractory arrhythmia with mexiletine.
Edward D. WONG ; John Kenneth C. REY-MATIAS ; Romeo C. GRIÑO
Philippine Journal of Cardiology 2026;54(S1):64-68
INTRODUCTION
Ventricular tachycardia (VT) storm is a condition characterized by recurrent ventricular arrhythmias within a 24-hour period, requiring a device or pharmacologic intervention. Despite its clinical significance, data on VT storm prevalence and treatment outcomes in the Filipino population remain limited
CASE REPORTWe present a 69-year-old male with heart failure from non-ischemic cardiomyopathy and an implantable cardioverter-defibrillator (ICD), who experienced multiple VT episodes unresponsive to amiodarone, lidocaine and mechanical cardioversion. He was initially admitted for catheter ablation but later developed a left ventricular thrombus precluding the procedure. Mexiletine was introduced and successfully suppressed arrhythmia recurrence
CASE DISCUSSIONThis case emphasized the complexity of managing ES, especially in patients with contraindications to ablation. Mexiletine, a class IB antiarrhythmic agent structurally similar to lidocaine, has shown efficacy in refractory VT, especially when standard therapies are ineffective or are contraindicated. Limited data exists on its safety for such cases, particularly in patients with intracardiac thrombus.
CONCLUSIONMexiletine may offer a viable treatment option for VT storm in patients ineligible for ablation due to left ventricular thrombus. While it was effective in this case, further studies are needed to validate its safety and long-term outcomes in similar high-risk populations.
Human ; Male ; Aged: 65-79 Yrs Old ; Tachycardia ; Clinical Relevance ; Arrhythmias, Cardiac ; Therapeutics ; Prevalence ; Tachycardia, Ventricular
5.Lived experiences of well-being of the University Athletic Association of the Philippines Season 84 student-athletes in bubble training during the COVID-19 pandemic: A qualitative phenomenological study.
Ken Erbvin R. SOSA ; Charles Nicolei M. NERMAL ; Karlos Lorenzo A. REA ; Gabrielle Atasha TANHUECO ; Isaac Miguel M. ANDICO ; Janelle Audre C. CHIU ; Timothy D. LAO ; Ma. Julia Isabelle G. PEÑALOZA ; John Mari R. QUILANG ; Zeuch Ryonin B. SILVA
Acta Medica Philippina 2025;59(18):81-98
BACKGROUND AND OBJECTIVE
The COVID-19 pandemic has disrupted the sports industry, resulting in the postponement of events worldwide. This posed a significant burden in the mental and emotional well-being of athletes due to uncertainties and diminished training levels. As an adaptation, bubble camps emerged as a new approach to resuming training and tournaments under stringent regulations of the COVID-19 protocols. In the national context, the University Athletic Association of the Philippines (UAAP) has adapted the bubble set-up by implementing antigen testing, RTPCR, and other health protocols as a prerequisite to bubble training. However, uncertainties in the future of sports continue to present as a psychological toll to the well-being of student-athletes despite the sense of normalcy instilled by bubble training. Existing literature on bubble training is grounded heavily on the quantitative assessments of an athlete's well-being in a bubble set-up and its effectiveness in mitigating COVID-19 transmission, thereby lacking insights that may be obtained from qualitative data. This study explored the experiences of UAAP Season 84 studentathletes in a bubble set-up by examining personal and contextual factors that impacted their well-being.
METHODSThe study employed a qualitative descriptive phenomenological approach based on Seligman's WellBeing Theory. A purposeful sampling technique was used to recruit UAAP student-athletes through online dissemination of Google Forms for recruitment. Only three student-athletes from UAAP fit the eligibility criteria. Data were collected through on-site and online interviews using a semi-structured interview guide to reveal a narrative of the student-athletes' bubble training experiences, common themes, and patterns. The NVivo software program was used for data analysis, utilizing a deductive thematic approach.
RESULTSThe lived experiences of three UAAP studentathletes were classified into six major themes: (1) Availability and Accessibility of Services; (2) Restrictions; (3) Mental Health; (4) Fostering Relationships; (5) Support Systems; and (6) Individual Growth. Accounts of both positive and negative training perceptions and outcomes regarding the bubble set-up were noted from all student-athletes. The set-up provided studentathletes with easy access to training facilities and services, eventual development of mental fortitude and perseverance, improved interpersonal relationships, and opportunities for individual growth. However, the restrictions, isolation, internal and external pressures, and routinary nature of the set-up contributed to the elevated levels of stress and anxiety, eventually leading to fatigue and burnout.
CONCLUSIONThe study elucidates on the multi-faceted experiences of UAAP student-athletes in bubble training, underpinning the essence of the adequacy of training services and facilities, enhanced support systems, and prompt policy development that caters to improving the holistic well-being of student-athletes amidst adverse changes in the trajectory of sports.
Human ; Qualitative Research ; Universities ; College Athletes ; Athletes
6.Bibliometric analysis of COVID-19-related publications in nursing by Philippine-based authors.
Peter James B. ABAD ; John Joseph B. POSADAS ; Julienne Ivan D. SOBERANO ; Ryan Q. DE TORRES ; Kenny-lynn B. BACCAY ; Maria Angela A. MABALE ; Marybel P. CAASI ; Arnold B. PERALTA
Acta Medica Philippina 2025;59(16):55-67
OBJECTIVE
To describe the trend and landscape of Coronavirus Disease (COVID-19)-related publications in nursing authored by at least one Philippine-based author.
METHODSThis study is a bibliometric analysis of documents retrieved from Scopus using the search terms “COVID-19” and “nurs*” in the article title, abstract, and keywords. The documents were limited to those published in English, affiliated with Philippine-based authors, and those published from 2020 to 2023. We used the ‘analyze report’ function in Scopus to analyze the data including the number of publications, types, sources, authors, and affiliations. We used VOSViewer for the co-authorship analysis of countries and co-occurrence analysis of author keywords.
RESULTSA total of 136 documents were found. Majority of these documents were classified as original articles (83%). There was a rapid increase in COVID-19 publications in nursing authored by at least one Philippine-based researcher published from 2020 to 2021 and plateaued from 2022-2023. Co-authorship analysis showed that Philippine-based authors have written documents with authors from 111 countries most notably from Saudi Arabia, the United States, Indonesia, and Australia. Most documents were published in the Belitung Nursing Journal. Authors from the University of Santo Tomas had the most publications. The most cited articles focused on psychosocial impacts, resilience, workplace stress, and online education. Author keywords commonly used in the documents were COVID-19, nursing, and nursing students, covering topics such as pandemic impacts, workplace impacts, nurse well-being, psychosocial impacts, and nursing education. Keywords have evolved through the pandemic period with a recent focus on stress and professional values.
CONCLUSIONPhilippine-based authors actively contributed in understanding the impact of COVID-19 on nurses and nursing education. Their scientific productivity was driven partly by their collaboration with foreign-based researchers. To sustain this trend in productivity and collaboration, policies, programs, and strategies are needed to promote, support, and foster research collaboration among local and international nursing researchers and institutions.
Human ; Bibliometrics ; Covid-19 ; Nursing ; Philippines
7.Auditory outcomes of cochlear implantation among pediatric patients under the Philippine National Cochlear Implant Program.
Nhor Albert C. ROBLES ; Charlotte M. CHIONG ; Karen Joyce S. VELASCO ; Anna Pamela C. DELA CRUZ ; Jaymilyn C. OMBAO ; Ma. Leah C. TANTOCO ; Rosario R. RICALDE ; Patrick John P. LABRA ; Chris Robinson D. LAGANAO
Acta Medica Philippina 2025;59(16):21-28
BACKGROUND
The National Cochlear Implant Program (NCIP) is a national program to address the increasing prevalence of hearing loss, especially in the pediatric population here in the Philippines. In its pilot implementation, it included three tertiary hospitals to represent Luzon, Visayas, and Mindanao and was able to enroll 20 patients who successfully underwent cochlear implantation.
OBJECTIVESThe aim of this study is to evaluate the auditory outcomes of the patients who underwent cochlear implantation under the NCIP using the Parents' Evaluation of Aural/Oral Performance of Children (PEACH) Questionnaire and Categories of Auditory Performance (CAP) score questionnaire.
METHODSThe study included all recipients of the cochlear implants, under NCIP from December 2019 to December 2021, except 1 with incomplete data during the course of his followup. The outcomes measured included the PEACH Questionnaire score and CAP Questionnaire score and were compared on various factors which included patient's sex and age, parents' socioeconomic status, duration of hearing aid use prior to CI, pre CI imaging findings and CI electrode placement using nonparametric statistical tests .
RESULTSThe mean PEACH score of the 19 patients was 53.59% ± 12.76% (range: 30% - 75%) while the mean CAP score was 3.16 ± 1.04 (range: 1 - 4.3). Parents of the included patients who have a higher educational background and those in which the electrode was located on the ideal location, scala tympani, have a statistically significant higher PEACH score (p-value of 0.017 and 0.012, respectively). In comparing the CAP scores, those who have unremarkable or normal preoperative imaging have a statistically significant higher score (p-value 0.013)
CONCLUSIONPatients who had normal preoperative imaging, proper placement of electrodes and those patients with parents belonging to a higher educational background had statistically significant better auditory outcomes after cochlear implantation. Patients who had the cochlear implantation before 36 months of age and hearing aid use of 7 to 18 months prior to cochlear implantation had higher PEACH and CAP scores, however these were not statistically significant. Further studies with a larger sample size is recommended.
Cochlear Implantation
8.Trends in knowledge, attitude and perceptions about HIV among Filipinos during and after the COVID-19 pandemic: Responses from a digital survey.
Glyzelle Anne A. LAGASON ; Judith Anne Rose Y. GANADEN ; Martin Xavier D. PEÑAFLOR ; Ericson P. ACAPULCO ; Kristine T. DONAYRE ; John Alexander L. FELLIZAR ; Ma. Tarcela S. GLER
Acta Medica Philippina 2025;59(15):88-93
BACKGROUND
The Philippines has been significantly affected by the HIV epidemic in the Asia-Pacific region, with a notable increase in new cases over the past decade. Despite efforts to promote HIV testing, access to treatment, and awareness campaigns, progress has been slow, particularly among youths. Tangere, a market research application, conducted surveys during and after the COVID-19 pandemic to assess HIV knowledge among Filipinos.
OBJECTIVESThis study aimed to evaluate changes in HIV awareness among young Filipinos during and after the COVID-19 pandemic using data collected via Tangere’s surveys. Specifically, it sought to analyze demographic characteristics, sources of HIV information, and knowledge regarding HIV transmission, prevention, and stigma.
METHODSTangere collaborated with the investigators to develop a questionnaire assessing HIV knowledge among young Filipinos. Surveys were conducted during and after the COVID-19 pandemic, targeting subscribers aged 18-35 years, primarily from the National Capital Region and Luzon area. Data analysis involved calculating frequencies and percentages to summarize demographic characteristics and HIV knowledge. An Independent-Samples Proportions procedure was used to compare HIV knowledge during and after the pandemic.
RESULTSThe survey revealed that while respondents generally possessed reasonable knowledge about HIV, there were notable changes in the awareness during and after the pandemic. Social media and television were identified as primary sources of HIV information. Knowledge regarding HIV transmission and prevention increased postpandemic, particularly concerning preventive measures such as pre-exposure prophylaxis (PREP) and motherto-child transmission (MTCT). However, persistent misconceptions and stigma surrounding HIV remained, indicating the need for continued education and advocacy efforts.
CONCLUSIONThe study underscores the importance of utilizing social media platforms for HIV awareness campaigns, especially among youths who are disproportionately affected by the epidemic. Despite improvements in knowledge, the Philippines has yet to achieve global HIV prevention goals. Continued efforts to enhance awareness, particularly regarding recent advancements in HIV prevention and treatment, are essential for curbing the epidemic and improving public health outcomes nationwide.
Human ; Knowledge ; Attitude ; Hiv ; Covid-19 ; Pandemics
9.A COVID-19 referral center’s cardiac catheterization laboratory response to the pandemic: A stakeholder analysis.
Aiza-meriam H. TAHIL ; Julian Alexander A. HUIBONHOA ; Cecileen Anne M. TUAZON. ; Jaime M. AHERRERA ; Eric Oliver D. SISON ; John C. ANONUEVO
Philippine Journal of Cardiology 2025;53(2):42-51
INTRODUCTION
The sudden designation as a COVID-19 Referral Center at the beginning of the pandemic brought about immense change to the Cardiac Catheterization Laboratory (CCL) services of a National Referral Center for tertiary care. As a proactive strategy to determine actions that can be undertaken should an unforeseen event ever happen again, this study was done to explore the impact of COVID-19 to the institution’s CCL caseload, and to review the challenges, innovations and adjustments made by the CCL to become pandemic-capable and crisis-ready.
METHODSA qualitative cross-sectional study was conducted, with the first phase describing the CCL census starting from the baseline pre-COVID year of 2019 to the pandemic years of 2020-2022, and the second phase involving Key Informant Interviews (KII) and Focus Group Discussion (FGD) with the hospital and CCL healthcare staff.
RESULTSThe study revealed a large reduction in the urgent, elective and overall number of cases of the CCL in the first year, but has seen a steady increase in subsequent years. Surges of COVID variants were also seen to affect the CCL caseload. The following were noted to be the key elements in the CCL’s transformation to become COVID-19 capable: (a) changes in operations and patient selection, (b) appropriate use of PPE, (c) strict adherence to an infection control protocol, and (d) staffing modifications to reduce infectivity and protect staff availability.
CONCLUSIONThe preparation of the hospital’s CCL to become a pandemic capable laboratory has been difficult and faced many challenges. However, the innovations and adjustments done through efforts and ingenuity of the CCL healthcare team allowed continuous delivery of the highest level of care to patients in spite of the changing pandemic landscape. These changes were duly documented as a basis for response to possible future global and/or national healthcare crises.
Human ; Covid-19 ; Pandemics
10.The effects of early vs late human or bovine milk fortification on growth and safety parameters in low birth-weight preterm neonates: asystematic review and meta-analysis.
Clayton John B. CHUA ; Roffel D. FELISILDA ; Christine M. GUZMAN
The Philippine Children’s Medical Center Journal 2025;21(2):49-79
Background: Premature infants benefit from human milk fortifiers for optimal growth, nutrition, neural development and reducing complications. However, the ideal timing for HMF introduction is still debated due to preterm infant’s immature digestive system and inconclusive study results, often marred by methodological flaws.
Objectives: To compare the effects of early human milk fortification (EHMF) vs late human milk fortification (LHMF) on low birth-weight (LBW) preterm neonates.
Methods: A systematic search for Randomized controlled trials comparing EHMF vs LHMF on LBW preterm neonates was conducted, covering databases such as Cochrane CENTRAL, Pubmed, Google Scholar and clinical trials registries iCRTP, ISRCTN and HERDIN from January 2000 to July 2024. Statistical analysis was performed using Review Manager version 5.3, with mean differences for continuous outcomes and risk ratio (RR) for dichotomous outcomes. A sensitivity analysis using the leave-one-out method and meta-regression was conducted to address potential confounding factors and publication biases were assessed through funnel plots.
Results:The EHMF group showed potential benefits in reducing the incidence of retinopathy of prematurity (ROP) and neonatal sepsis, achieving a faster time to regain birth weight. However, there may be an increased risk of bronchopulmonary dysplasia and the effects of necrotizing enterocolitis and feeding intolerance (FI) may be unclear. Interestingly, given the high precision of pooled effects on growth, hospital outcomes (length and time to reach full feeds) and adverse effects (extra-uterine growth restriction) no significant difference between groups were noted.
Conclusions:The study suggests that EHMF could impact growth parameters and reduced adverse outcomes, although most effects were not significant. The wide confidence intervals around some effect sizes suggest a need for more robust studies to resolve these uncertainties.
Human ; Male ; Female


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