Objective To investigate the factors influencing shorter survival in standard-risk multiple myeloma(MM)patients as defined by the mSMART3.0 criteria,and to provide a basis for constructing a more precise risk prediction model for MM patients.Methods A retrospective analysis was conducted on 388 MM patients from the First Affiliated Hospital of Chongqing Medical University between January 2015 and January 2022.Clinical baseline data,laboratory test results,and overall survival(OS)data were collected.SPSS 27.0 software was used for the analysis of relevant factors,with a P-value of less than 0.05 considered statistically significant.Results Analysis of the 82 mSMART 3.0 standard-risk MM patients revealed that age(P＜0.01)and monocyte percentage(P=0.025)differed significantly between the groups with differing survival outcomes.Further COX regression analysis indicated that advanced age(HR=1.057,95％CI:1.022-1.093,P=0.01)and a high monocyte percentage(HR=1.115,95％CI:1.041-1.193,P=0.02)were independent risk factors influencing the OS of standard-risk MM patients.Conclusion Both age and monocyte percentage are independent adverse factors affecting the survival of standard-risk MM patients ac-cording to the mSMART 3.0 staging system.Incorporating these factors into the stratification criteria is ex-pected to enhance the accuracy of risk stratification.

Totally 896 medical records were statistically analyzed from Jan. 1, ] 998 to Dec. 31 , 2001. There were 65 cases (7. 3%,65/896) of ischemic cardiomyopathy .of which 38 cases (58. 5% .38/65) were myocardial infarction in small area, 27 cases(41. 5% ,27/65) were in large area. The causes of ischemic cardiomyopathy were lack of blood supply in cardiac cells for a long time and pathological changes in branches of coronary artery. If myocardial infarction in small area occurred,the blood vessels should be opened again in acute period, and the risk factors must be prevented and treated.