Objective To explore the influencing factors for delayed resuscitation from anaesthesia in patients undergoing pancreatic cancer surgery and to develop a prediction model and evaluate its predictive performance.Methods This study included 300 patients who had surgery under general anaesthesia for pancreatic cancer at a Tier-IIIA hospital in Jiangsu Province between September 2023 and February 2024.The patients who had the surgery between September and December 2023(n=208)were assigned to the modelling group,and those between January to February 2024(n=92)to the validation group.Baseline perioperative data were recorded.Binary logistic regression was used to identify risk factors for delayed resuscitation,and a risk prediction model was finally developed and validated.Results Over 60 years of age,bispectral index(BIS)monitoring,combined with regional block anaesthesia,and rescue analgesia were identified as the risk factors for delayed resuscitation(all P<0.05).The Hosmer-Lemeshow test confirmed a good model fit(P>0.05).The C-index value was 0.807 for the modelling group and 0.841 for the validation group.The area under the curve(AUC)of receiver operating characteristic(ROC)was 0.807(95%CI 0.738～0.876)for the modelling group and 0.841(95%CI 0.742～0.940)for the validation group,with both calibration curves close to the ideal curve.Conclusion The developed prediction model for delayed resuscitation exhibits a good predictive performance and it can serve as a reference for clinical staff.

Objective To explore the influencing factors for delayed resuscitation from anaesthesia in patients undergoing pancreatic cancer surgery and to develop a prediction model and evaluate its predictive performance.Methods This study included 300 patients who had surgery under general anaesthesia for pancreatic cancer at a Tier-IIIA hospital in Jiangsu Province between September 2023 and February 2024.The patients who had the surgery between September and December 2023(n=208)were assigned to the modelling group,and those between January to February 2024(n=92)to the validation group.Baseline perioperative data were recorded.Binary logistic regression was used to identify risk factors for delayed resuscitation,and a risk prediction model was finally developed and validated.Results Over 60 years of age,bispectral index(BIS)monitoring,combined with regional block anaesthesia,and rescue analgesia were identified as the risk factors for delayed resuscitation(all P<0.05).The Hosmer-Lemeshow test confirmed a good model fit(P>0.05).The C-index value was 0.807 for the modelling group and 0.841 for the validation group.The area under the curve(AUC)of receiver operating characteristic(ROC)was 0.807(95%CI 0.738～0.876)for the modelling group and 0.841(95%CI 0.742～0.940)for the validation group,with both calibration curves close to the ideal curve.Conclusion The developed prediction model for delayed resuscitation exhibits a good predictive performance and it can serve as a reference for clinical staff.

Growth stimulating gene 2 (ST2) protein is a member of the interleukin-1 receptor family. It is mainly divided into a soluble secreted form sST2 and a transmembrane form ST2L. sST2 is a decoy receptor that competitively binds to interleukin-33 to block the interleukin-33/ST2L signaling pathway, worsening myocardial hypertrophy, fibrosis, and ventricular dysfunction. Measuring sST2 is of important value for diagnosis and/or prognosis evaluation of cardiovascular diseases. This paper mainly reviews the research progress in the relationship between cardiovascular diseases such as heart failure, coronary heart disease, hypertension, atrial fibrillation, myocarditis, cardiomyopathy, acute aortic dissection, and pulmonary hypertension, and sST2.

Objective To study the possible mechanism of hearing impairment after noise exposure .Methods Adult SD rats (n=14) were monaurally exposed to a loud noise (16 kHz ,one octave band pass (116 dB SPL)) for 1-hour ,or left as non-exposed controls (n=8) .The ABR was measured before and on the 7th day following unilateral noise exposure .All the Animals were euthanased at 7th day following acoustic trauma .We used Western blots to quantify protein levels of PV ,CR and CB in the inferior colliculus .Results The auditory thresholds in 8 , 12 ,16 ,20 ,24 ,and 32 kHz of all the ears exposed to noise showed a significant increase (P<0 .001) .Compared to the sham -exposed controls ,noise-exposed animals had significantly higher levels of PV and CR and lower levels of CB in both the ipsilateral and contralateral IC than controls (P<0 .05) .Respectively ,all the noise-exposed ani-mals had higher levels of PV and CR in the ipsilateral IC than ipsilateral side (P<0 .05) .Conclusion These studies display a significant threshold shift and changes on the expressions of PV ,CR and CB in IC following acoustic trau-ma ,which may be related to noise deafness ,tinnitus and other series of auditory dysfunction .

Objective To study the incidence and duration of residual dizziness after successful repositioning treatment in patients with benign paroxysmal positional vertigo(BPPV) and the clinical factors associated with the residual dizziness.Methods A total of 202 cases of confirmed BPPV patients,61 males and 141 females with the average age of 54.78± 13.71 years old,were followed up for 2 months after successful particle repositioning.The incidence and duration of residual dizziness were analyzed.The risk factors for residual dizziness were analyzed by logistic regression.Results A total of 202 cases of confirmed BPPV were included in this study,and 113 cases complained of residual dizziness.Over the time,residual dizziness disappeared gradually.The differences of the age,the duration of vertigo before treatment,recurrent,and underlying diseases between the two group were significant (P ＜0.05),while the side,the gender,the incubation period of BPPV,the duration time of BPPV,and the types of canals were not associated with the residual dizziness(P＞0.05).The logistic regression analysis showed that the duration of vertigo before treatment and the age were the risk factors for residual dizziness.Conclusion More than half of the patients included in this study complained of residual dizziness after particle repositioning,and the symptoms disappeared naturally.The duration of vertigo before treatment and the age were the risk factors for residual dizziness.

Objective: To explore sarcoplasmic reticulum ryanodine receptor2 (RyR 2) expression and calcium releasing function in chronic heart failure (CHF) rabbits and to study the impact of long term valsartan treatment in relevant animals. Methods: HF model was established by volume overloading with pressure overloading in experimental rabbits. 27 rabbits were divided into 3 groups: Sham group, HF group and HF+valsartan group. n=9 in each group and the animals were treated for 7 weeks. Left ventricular structure, hemodynamic parameters, expression and functional changes of myocardiocyte sarcoplasmic reticulum RyR 2 were observed and compared among different groups. Results: Compared with Sham group, HF group had increased left ventricular mess index (LVMI), left ventricular end diastolic pressure (LVEDP) and decreased left ventricular shortening fraction, LVEF, all P<0.05. Compared with HF group, HF+valsartan group showed decreased LVMI, LVEDP and increased left ventricular shortening fraction, LVEF, all P<0.05. Sarcoplasmic reticulum RyR 2 expression and calcium releasing function were lower in HF group than Sham group, P<0.05; while they were both higher in HF+valsartan group than HF group, P<0.05. Conclusion: Long term application of valsartan could improve the cardiac function which might be related to increased myocardial sarcoplasmic reticulum RyR 2 expression and calcium releasing function in experimental CHF rabbits.

OBJECTIVE: Evaluation and analyze the characteristics of balance function in patients with type 2 diabetes, and to find out the importance of proprioception, vision and vestibular in postural control. METHOD: All subjects were divided into two groups, 37 normal individuals, 33 patients with type 2 diabetes mellitus. All were assessed by computerized posturography under six upright stance.conditions: including standing on the firm surface and foam with eyes open and closed. RESULT: (1) On anteroposterior,the scores of proprioception, vision and vestibular were 93.96 ± 7.95, 80.22 ± 16.24, 70.87 ± 20.99, the normal were 98.00 ± 2.18, 91.44 ± 6.01, 80.44 ± 7.81. There were significances between diabetes mellitus group and normal control group (P < 0.05) respectively. (2) On lateral, the scores of vision and vestibular were 80.39 ± 12.60, 73.96 ± 16.04, and the normal were 92.11 ± 4.50, 83.18 ± 9.45. There were significances with P < 0.05 between diabetes mellitus group and normal control group. However, there was no obvious difference in proprioception scores between the two groups. (3) The limit of stability of normal group were (176.47 ± 44.13) mm²; diabetic group was (143.13 ± 62.30) mm². There was statistical significance between the group with P < 0.05. (In diabetic patients, there was no significant difference between the no dizziness group and the dizziness group of the scores of proprioceptive, visual, vestibular as well as stable limits, P > 0.05. CONCLUSION The balance function of patients with type 2 diabetes decreased. It is the main characteristic that the vision and vestibular decreased more significantly in the postural control.
Case-Control Studies ; Diabetes Mellitus, Type 2 ; physiopathology ; Dizziness ; complications ; Humans ; Postural Balance ; Proprioception ; Vertigo ; complications ; Vestibule, Labyrinth ; physiopathology ; Vision, Ocular

OBJECTIVE:To provide reference for improving the practical application of fluorescence quantitative reverse tran-scription-polymerase chain reaction (RT-PCR) for the live-attenuated mumps vaccine manufacturing. METHODS:A regression equation of standard titer-ct value was established;micro cytopathic effect(micro-CPE)and fluorescence quantitative RT-PCR were respectively adopted for the titer of 10 batches of single harvest liquid of live-attenuated mumps vaccine and end products,and the results were compared. RESULTS:According to the t-test analysis,the P were respectively 0.743 and 0.868,and the average val-ues were in the range of (-0.174,0.094) and (-0.113,0.153),with no significant differences. They were similar. CONCLU-SIONS:Fluorescence quantitative RT-PCR can be used for the titer detection of single harvest liquid and end products in the pro-cess of live-attenuated mumps vaccine manufacturing. And it is expected to further upgrade to Chinese Pharmacopoeia method.