Objective To analyze the correlation between anxiety symptoms and abnormal brain function in patients with chronic obstructive pulmonary disease (COPD) under long-term chronic hypoxia. Methods Twenty-one patients with COPD complicated with anxiety were prospectively selected as COPD group, and 26 healthy individuals matched for gender and age were selected as control group. Both groups underwent high-resolution 3D-T1-weighted imaging (3D-T1WI), T2-fluid-attenuated inversion recovery (T2-FLAIR), and blood oxygen level dependent (BOLD) sequence examination. DPARSF and SPM8 software were used to analyze the amplitude of low-frequency fluctuations (ALFF) in the brain of the two groups. Results In the COPD group, the ALFF value in the left parahippocampal gyrus-cingulate gyrus increased, and the ALFF value in the right superior frontal gyrus decreased (P < 0.05). Pearson correlation analysis found that there was a negative correlation between the ALFF value in the right superior frontal gyrus and the anxiety score (r=-0.485, P=0.03). Conclusion Chronic hypoxic patients with COPD have brain functional impairment in the right superior frontal gyrus, and the degree of impairment is positively correlated with anxiety symptoms. There may also be compensatory enhancement of brain function activity in the parahippocampal gyrus-cingulate gyrus.

Objective The aim of this study was to investigate the expression of IL-23(IL-23)in breast cancer and its cor-relation with clinicopathological characteristics.Methods The tumor tissues and adjacent tissues of 100 patients with breast cancer diagnosed in Nanchong Central Hospital from January 2020 to December 2020 were collected.Immunohistochemistry and Real-Time PCR were used to determine the expression of IL-23 protein and mRNA in the two groups of tissues.The expression of IL-23 protein and mRNA in breast cancer tissues and adjacent tissues were compared,and the relationship between IL-23 expression and the clini-copathological characteristics of breast cancer was analyzed.Results IL-23 protein was mainly expressed in the membrane and cyto-plasm of breast cancer cells.The expression of IL-23 protein and mRNA in breast cancer tissues were higher than those in adjacent tissues(P<0.001).The expression of IL-23 protein and mRNA was positively correlated with the histological grade,T grade,clinical stage and Ki-67 expression of breast cancer,negatively correlated with the expression of ER and PR(P<0.05),and was not related to neurovascular invasion,age and HER-2 expression in breast cancer(P>0.05).Conclusion IL-23 may participate in the progres-sion of breast cancer,and its expression is closely related to ER,PR,Ki-67 and other prognostic indicators,suggesting that its expres-sion may be related to the prognosis,but it needs further experimental verification.

Objective The aim of this study was to investigate the expression of IL-23(IL-23)in breast cancer and its cor-relation with clinicopathological characteristics.Methods The tumor tissues and adjacent tissues of 100 patients with breast cancer diagnosed in Nanchong Central Hospital from January 2020 to December 2020 were collected.Immunohistochemistry and Real-Time PCR were used to determine the expression of IL-23 protein and mRNA in the two groups of tissues.The expression of IL-23 protein and mRNA in breast cancer tissues and adjacent tissues were compared,and the relationship between IL-23 expression and the clini-copathological characteristics of breast cancer was analyzed.Results IL-23 protein was mainly expressed in the membrane and cyto-plasm of breast cancer cells.The expression of IL-23 protein and mRNA in breast cancer tissues were higher than those in adjacent tissues(P<0.001).The expression of IL-23 protein and mRNA was positively correlated with the histological grade,T grade,clinical stage and Ki-67 expression of breast cancer,negatively correlated with the expression of ER and PR(P<0.05),and was not related to neurovascular invasion,age and HER-2 expression in breast cancer(P>0.05).Conclusion IL-23 may participate in the progres-sion of breast cancer,and its expression is closely related to ER,PR,Ki-67 and other prognostic indicators,suggesting that its expres-sion may be related to the prognosis,but it needs further experimental verification.

Keloid is defined as special pathological scar invading adjacent healthy skin. The pathogenesis of keloid is not yet fully elucidated. Many factors such as epigenetic inheritance, inflammatory response and mechanical tension have been shown relating to keloid. In recent years, with the rapid progress of epigenetics, more and more studies on long noncoding RNA (lncRNA) have confirmed that it is closely related to keloid formation. Based on the research results of lncRNA, this article reviews its roles in formation and invasion of keloid, by analyzing the relationship between lncRNA and abnormal proliferation of fibrocytes, excessive collagen formation, cell microenvironment, cell migration and other processes.

Keloid is defined as special pathological scar invading adjacent healthy skin. The pathogenesis of keloid is not yet fully elucidated. Many factors such as epigenetic inheritance, inflammatory response and mechanical tension have been shown relating to keloid. In recent years, with the rapid progress of epigenetics, more and more studies on long noncoding RNA (lncRNA) have confirmed that it is closely related to keloid formation. Based on the research results of lncRNA, this article reviews its roles in formation and invasion of keloid, by analyzing the relationship between lncRNA and abnormal proliferation of fibrocytes, excessive collagen formation, cell microenvironment, cell migration and other processes.

Keloid is defined as special pathological scar invading adjacent healthy skin. The pathogenesis of keloid is not yet fully elucidated. Many factors such as epigenetic inheritance, inflammatory response and mechanical tension have been shown relating to keloid. In recent years, with the rapid progress of epigenetics, more and more studies on long noncoding RNA (lncRNA) have confirmed that it is closely related to keloid formation. Based on the research results of lncRNA, this article reviews its roles in formation and invasion of keloid, by analyzing the relationship between lncRNA and abnormal proliferation of fibrocytes, excessive collagen formation, cell microenvironment, cell migration and other processes.

Keloid is defined as special pathological scar invading adjacent healthy skin. The pathogenesis of keloid is not yet fully elucidated. Many factors such as epigenetic inheritance, inflammatory response and mechanical tension have been shown relating to keloid. In recent years, with the rapid progress of epigenetics, more and more studies on long noncoding RNA (lncRNA) have confirmed that it is closely related to keloid formation. Based on the research results of lncRNA, this article reviews its roles in formation and invasion of keloid, by analyzing the relationship between lncRNA and abnormal proliferation of fibrocytes, excessive collagen formation, cell microenvironment, cell migration and other processes.

Objective To investigate the relationship between low-density lipoprotein cholesterol/high-density lipoprotein cholesterol ratio (LHR) and asymptomatic carotid plaques and their stability in high-risk stroke population.Methods Between December 2012 and April 2015,a total of 39 944 permanent resident population ≥40 years were used as subjects of the survey from 11 rural communities in Haitou Town,Banzhuang Town and Tashan Town,Ganyu District,and 9 urban communities in Xinpu District and Haizhou District,Lianyungang City using epidemiological survey method of cluster sampling.Excluding those who took lipid-lowering drugs within 3 months and had a history of stroke or transient ischemic attack,6 592 people at high risk of stroke were finally screened out.Ultrasound was used to detect carotid plaques.The subjects were divided into plaque-free group and plaque group.The latter was further divided into stable plaque group and unstable plaque group.Multivariate logistic regression analysis was used to evaluate the independent risk factor for carotid plaques and their stability.The odds ratio (OR) and 95％ confidence interval (CI) were calculated.Receiver Operating Characteristic (ROC) curve was used to evaluate the prediction efficiency of LHR on carotid plaques.Results Multivariate logistic regression analysis showed that low-density lipoprotein cholesterol (LDL-C) was an independent risk factor for carotid plaques,while high-density lipoprotein cholesterol (HDL-C) was an independent protection factor of carotid plaques.Using the lowest quintile (Q1) of LHR as a reference,carotid plaque risk increased significantly with the increasing LHR (Q2:OR 1.448,95％ CI 1.082-1.937,P =0.013;Q3:OR 2.414,95％ CI 1.754-3.322,P＜0.001;Q4:OR 2.939,95％ CI 1.945-4.441,P＜0.001;Q5:OR 4.884,95％ CI 3.143-7.115,P＜0.001).ROC curve analysis showed that the area under the curve (AUC) of LHR predicting carotid plaques was 0.795 (95％ CI 0.792-0.807;P＜ 0.001),and the optimal cut-off value was 3.00 (sensitivity 68.37％,specificity 75.65％).LHR ≥3.92 (LHR in the Q4 and Q5 subgroups) was an independent risk factor for unstable carotid plaques (OR 2.915,95％ CI 2.104-4.040;P＜0.001).The AUC of the LHR predicting unstable carotid plaques was 0.658 (95％ CI 0.633-0.684;P＜0.001).Conclusions LHR was an independent predictor of carotid plaques in high-risk stroke patients.It had higher predictive value for carotid plaques,and its conversion threshold for promoting plaque formation was 3.00.When LHR was ≥3.92,there was a significant increase in the risk of unstable carotid plaques.

Objective To investigate the correlations of apparent diffusion coefficient (ADC) with fibrosis and fibroblast activation protein (FAP) score in pancreatic cancer .Methods Eighteen patients with pathologically confirmed pancreatic cancer were per‐formed conventional MR imaging ,DWI examinations .ADCs were measured with region of interest method on a “Single slice” .The wax blocks of 18 patients with pancreatic cancer were received Masson staining and FAP immunohistochemical staining .The correla‐tions of ADC with levels of fibrosis and FAP scores of pancreatic cancer were assessed by Pearson correlation analysis .Results The mild negative correlation between ADC value of cancerous foci and fibrosis was not significant (r= -0 .459 ,P=0 .056) .Significant negative correlation was found between ADC values of moderate and high differentiation cancerous foci and fibrosis (r= -0 .564 ,P=0 .044) .Significant negative correlation was found between ADC value and FAP score (r= -0 .497 , P=0 .036) .Conclusion The negative correlations are found between ADC and fibrosis ,FAP score of pancreatic cancer .DWI will be helpful to infer the pathologi‐cal characteristics .

Purpose To assess the diagnostic value of 18F-FLT and 18F-FDG PET/CT scan in patients with lung cancer. Materials and Methods Computer-based retrieval was performed on Medline, PubMed, EMbase, Wanfang data, CNKI and the Cochrane Library to search reports on diagnostic value of lung cancer with 18F-FLT and 18F-FDG PET/CT scan. The quality of included studies was evaluated according to quality assessment of diagnostic accuracy studies (QUADAS), and MetaDisc software was adopted to conduct meta-analysis. The pooled specificity, sensitivity, and diagnostic odds ratio (DOR) were calculated. The heterogeneity was tested. The summary receiving operating characteristic (SROC) curve was drawn, and the areas under the curve (AUC) as well as Q* were measured. Results Ten studies were included. Meta-analysis showed pooled sensitivity was 0.88, pooled specificity was 0.56, DOR was 9.10, AUC was 0.8102, Q*was 0.7448 for FDG group;pooled sensitivity was 0.79, pooled specificity was 0.78, DOR was 12.50, AUC was 0.8440, Q*was 0.7756 for FLT group. Conclusion Both 18F-FDG and 18F-FLT have well diagnostic value for lung cancer, but the specificity of 18F-FLT is higher than that of 18F-FDG in the diagnosis of lung cancer.