Myxedema coma is a rare condition, typically arising from long-standing, untreated hypothyroidism and triggered by factors such as infection, hypothermia, or severe illness. This report details a successfully treated case of myxedema coma with cardiac attest, accompanied by a literature review, to enhance clinical awareness and improve the diagnosis and management of this critical condition.

Myxedema coma is a rare condition, typically arising from long-standing, untreated hypothyroidism and triggered by factors such as infection, hypothermia, or severe illness. This report details a successfully treated case of myxedema coma with cardiac attest, accompanied by a literature review, to enhance clinical awareness and improve the diagnosis and management of this critical condition.

Objective:To investigate soft-and hard-tissue changes after simultaneously labial and lingual augmented corticotomy in patients with insufficient alveolar bone thickness of lower anterior teeth both in labial and lingual side during orthodontic treatment.Methods:From January 2021 to June 2022, 10 patients [2 males and 8 females, (26.2±3.1) years old] who received orthodontic and orthognathic combined treatment from the Fourth Clinical Division, Peking University School and Hospital of Stomatology were selected. The alveolar bone thickness of lower anterior teeth both in labial and lingual side in these patients was less than 0.5 mm according to cone-beam CT examination before or during treatment, and 60 lower anterior teeth were included. The 10 patients were treated with simultaneously labial and lingual augmented corticotomy. The differences in gingival recession, papilla index and the differences in labial and lingual alveolar bone thickness of lower anterior teeth were compared.Results:Six months after surgery, the alveolar bone thicknesses at the 4 mm under cemento-enamel junction (CEJ), 8 mm under CEJ and at the apical level [labial side: (1.02±0.39), (2.22±0.89) and (4.87±1.35) mm; lingual side: (1.07±0.46), (2.31±1.04) and (3.91±1.29) mm] were significantly higher than that before surgery [labial side: (0.02±0.09), (0.06±0.21) and (2.71±1.33) mm]; lingual side: (0.14±0.29), (0.40±0.52) and (2.13±1.02) mm] ( P<0.001), respectively. The increases in alveolar bone thickness of central incisors [apical level on labial side: (2.53±1.20) mm, 8 mm under CEJ on lingual side: (2.27±1.24) mm, apical level on lingual side: (2.66±1.49) mm] and lateral incisors [apical level on labial side: (2.42±1.30) mm, 8 mm under CEJ on lingual side: (2.28±0.92) mm, apical level on lingual side: (1.94±1.15) mm] were significantly higher than that of canines [apical level on labial side: (1.52±1.47) mm, 8 mm under CEJ on lingual side: (1.17±1.09) mm,apical level on lingual side: (0.74±1.37) mm] ( P<0.01). There were no significant differences in the degree of gingival recession [labial side before surgery: (0.72±0.88) mm, lingual side before surgery: (0.80±1.09) mm; labial side 6 months after surgery: (0.72±0.81) mm,lingual side 6 months after surgery: (0.89±0.21) mm] and gingival papilla index [before surgery: 1.00(0.75, 2.00); 6 months after surgery: 1.00(1.00, 2.00) ] between pre-operation and 6 months after surgery ( P>0.05). No serious complications occurred. Conclusions:The method used in this article for simultaneously labial and lingual augmented corticotomy was safe and feasible. This surgery has positive clinical significance for the stability of the periodontal tissue in orthodontic treatment for patients with alveolar bone thickness less than 0.5 mm of lower anterior teeth both in labial and lingual side.

Objective:To observe the effect of the combination therapy of Qingtong formula and Dapagliflozin on the renal function of diabetic mice.Methods:A total of 24 10-week-old diabetic model（db/db）mice were selected and divided into four groups with six db/db mice in each group by random number table method：db/db mice（control group），db/db mice + Dapaglifozin（western medicine group），db/db mice + Dapagliflozin + Qingtong formula［traditional Chinese medicine（TCM）combined with western medicine group］，and db/db mice + Qingtong formula（TCM group）. The changes of urine creatinine and urinary albumin / creatinine（ACR）before and after treatment were compared，and the levels of serum creatinine and urea nitrogen after treatment were also compared.Results:After treatment，the serum creatinine level in the TCM combined with western medicine group showed a downward trend compared with that of the control group and significantly decreased compared with the western medicine group and the TCM group，and the difference was statistically significant（ P < 0.01）. There was no significant difference in urea nitrogen level among all groups（ P > 0.05）. After treatment，urinary creatinine level in the TCM combined with western medicine group was significantly higher than those in other three groups，with statistical significance differences（ P < 0.05 or P < 0.01）. There was no significant difference in urinary ACR level among groups before and after treatment（ P > 0.05）. Conclusion:The combination therapy of Qingtong formula and Dapaglifozin can significantly increase urine creatinine excretion of db/db mice，lower the level of serum creatinine，thus improving renal function.

Objective:To observe the effect of the combination therapy of Qingtong formula and Dapagliflozin on the renal function of diabetic mice.Methods:A total of 24 10-week-old diabetic model（db/db）mice were selected and divided into four groups with six db/db mice in each group by random number table method：db/db mice（control group），db/db mice + Dapaglifozin（western medicine group），db/db mice + Dapagliflozin + Qingtong formula［traditional Chinese medicine（TCM）combined with western medicine group］，and db/db mice + Qingtong formula（TCM group）. The changes of urine creatinine and urinary albumin / creatinine（ACR）before and after treatment were compared，and the levels of serum creatinine and urea nitrogen after treatment were also compared.Results:After treatment，the serum creatinine level in the TCM combined with western medicine group showed a downward trend compared with that of the control group and significantly decreased compared with the western medicine group and the TCM group，and the difference was statistically significant（ P < 0.01）. There was no significant difference in urea nitrogen level among all groups（ P > 0.05）. After treatment，urinary creatinine level in the TCM combined with western medicine group was significantly higher than those in other three groups，with statistical significance differences（ P < 0.05 or P < 0.01）. There was no significant difference in urinary ACR level among groups before and after treatment（ P > 0.05）. Conclusion:The combination therapy of Qingtong formula and Dapaglifozin can significantly increase urine creatinine excretion of db/db mice，lower the level of serum creatinine，thus improving renal function.

Objective:To explore the possible role of endoplasmic reticulum aminopeptidase 1 (ERAP1), tumor necrosis factor-α receptor Ⅰ (TNFR-Ⅰ), tumor necrosis factor-α receptor Ⅱ (TNFR-Ⅱ) in the pathogenesis of psoriasis vulgaris.Methods:15 cases of normal skin and 20 cases of psoriasis vulgaris in Xinjiang Uygur Autonomous Region People's hospital were enrolled. Immunohistochemical staining techniques were used to detect the expression of ERAP1, TNFR-Ⅰ, TNFR-Ⅱ protein in the two groups. Statistical analysis was then performed to compare the difference in expression between the two groups.Results:⑴ In normal skin , ERAP1 is mainly expressed in the basal layer of the epidermis. In the psoriatic vulgaris lesions, ERAP1 was diffusely positive. The expression of ERAP1 in the psoriatic lesions was stronger than that of normal tissues, with stastically significant difference ( Z=-4.170, P<0.05). ⑵ TNFR-Ⅰ is diffusedly expressed in the normal skin tissues. However, in the epidermis of psoriatic lesions, the expression of TNFR-Ⅰ in the spinous layer was stronger than that of the basal layer (χ 2=17.740, P<0.05). ⑶ In the normal skin, TNFR-Ⅱ was not expressed; in the psoriatic lesions, TNFR-Ⅱ was diffusely expressed in the basal cell layer and acanthosis of the epidermis in varying degrees, and the difference between normal and psoriatic skin was statistically significant (χ 2=17.500, P<0.001). ⑷ The expression of ERAP1 in the epidermis of psoriasis vulgaris was negatively correlated with TNFR-Ⅰ ( rs=-0.662, P=0.001). There was no significant correlation between ERAP1 and TNFR-Ⅱ ( rs=0.343, P=0.139). Conclusions:ERAP1, TNFR-Ⅰ, and TNFR-Ⅱ may play important roles in the pathogenesis of psoriasis vulgaris. They may interact with each other to regulate the proliferation and apoptosis of keratinocyte in order to maintain the abnormal proliferation and benign proliferation of psoriasis vulgaris epidermis.

Up to 80% of type 1 diabetes melitus children present with diabetic ketoacidosis (DKA). Stroke in children with DKA children is uncommon but life-threatening. Various types of stroke, such as ischemic, cerebral venous thrombosis, and hemorrhagic stroke were observed in children with DKA. In this article, we review the literatures regarding stroke in children with DKA.

Objective To evaluate the preliminary screening effect of the ESS、SAQLI and QOLOSAHS for OSAHS,and find out the most effective preliminary screening method.Methods The scores of ESS、SAQLI、QOL-OSAHS of the 93 participants were analyzed.The predictive values of the three scales for OSAHS were determined by receiver operator curve and discriminatory analysis.Results The sensitivity and specificity of ESS(ESS≥9 points) were 0.486 and 0.870.The sensitivity and specificity of SAQLI (≤246 points) were 0.914 and 0.522.The sensitivity and specificity of QOL-OSAHS (≤161 points) were 0.886 and 0.522.Conclusions ESS、SAQLI、QOL-OSAHS have moderate predictive value for OSAHS.SAQLI is better to drinker than ESS for diagnosis of OSAHS.