Enhancing the proactive risk management function of the Rapid Response System(RRS)can effectively im-prove its critical care capabilities.Panyu Hospital of Traditional Chinese Medicine of Guangzhou(Panyu Hospital Guangzhou University of Chinese Medicine)has established the ABCDE-RRS system for critical care,which stands for Able(enhanced post capacity),Broad(diverse quality control),Comprehensive(full participation),Deep(continuous talent cultivation and system optimization),and Early(proactive risk management).This system ensures that the number of critically ill hospitalized patients continues to grow(an increase of 8.99％in the first three quarters of 2024 compared to the same period last year,P＜0.05)while effectively reducing the all-cause mortality rate of hospitalized patients(a decrease of 0.05％in the first three quarters of 2024 compared to the same period last year,P＜0.05).It also enhances the safety culture awareness among all staff(an in-crease of 39.05％after implementation,P＜0.05)and improves patient satisfaction with the hospital(the comprehensive patient evaluation ranking of public hospitals in Guangzhou improved from 17th to 12th place).By establishing an effective operational model for ABCDE-RRS and a tiered talent training model for RRS,this provides a replicable template for the construction of RRS in primary hospitals.

Enhancing the proactive risk management function of the Rapid Response System(RRS)can effectively im-prove its critical care capabilities.Panyu Hospital of Traditional Chinese Medicine of Guangzhou(Panyu Hospital Guangzhou University of Chinese Medicine)has established the ABCDE-RRS system for critical care,which stands for Able(enhanced post capacity),Broad(diverse quality control),Comprehensive(full participation),Deep(continuous talent cultivation and system optimization),and Early(proactive risk management).This system ensures that the number of critically ill hospitalized patients continues to grow(an increase of 8.99％in the first three quarters of 2024 compared to the same period last year,P＜0.05)while effectively reducing the all-cause mortality rate of hospitalized patients(a decrease of 0.05％in the first three quarters of 2024 compared to the same period last year,P＜0.05).It also enhances the safety culture awareness among all staff(an in-crease of 39.05％after implementation,P＜0.05)and improves patient satisfaction with the hospital(the comprehensive patient evaluation ranking of public hospitals in Guangzhou improved from 17th to 12th place).By establishing an effective operational model for ABCDE-RRS and a tiered talent training model for RRS,this provides a replicable template for the construction of RRS in primary hospitals.

Objective To explore the protective effect of brain-derived neurotrophic factor (BDNF) on cultured rat cortical neurons against glutamate (Glu)-induced injury and its mechanism. Methods Cortical neurons were primarily cultured from 1-day-old newborn Sprague-Dawley rats and then cultured for 7 d. The cortical neurons were divided randomly into 3 groups: control group,Glu group and BDNF group after identified with neuron-specific enolase (NSE) immunostaining. The cells of BDNF were treated with 50 ng/ml BDNF on day 6 for 24 h followed by cultured with 50 ?mol/L Glu for 0.5 h. While,the cells of Glu group were cultured with 50 ?mol/L Glu for 0.5 h on day 7. The control cells received no such treatments. On day 8,cell viability were determined by the colorimetric MTT assay. The morphological features of the neuron cells were observed under AO/EB fluorescence microscopy. Expressions of p75NTR,JNK and ERK were observed using Western blot analysis. Results On day 8,the primary cortical neurons grew well. BDNF protected cortical neural cells from Glu injury. Cell viability of BDNF group was (1.14?0.06),significantly higher than that of Glu group (0.72?0.10,P