The management of non-small cell lung cancer is rapidly advancing toward precision and individualized care. The National Comprehensive Cancer Network (NCCN) has recently released the 2026 version 1, 2, and 3 updates of the NCCN Clinical Practice Guidelines in Oncology: Non-Small Cell Lung Cancer. These updated guidelines introduce significant revisions in several core areas, including the adoption of the AJCC 9th Edition TNM Staging System, optimization of recommendations for lung cancer screening and mediastinal staging, updates on perioperative immunotherapy and targeted therapy strategies, and the inclusion of emerging biomarkers such as neuregulin 1 (NRG1) fusions and mesenchymal-epithelial transition factor (MET) protein overexpression. This article provides a systematic interpretation of these key updates and focuses on integrating international guidelines with clinical practice in China. Specifically, considering the high prevalence of epidermal growth factor receptor (EGFR) mutations in the Chinese population, it analyzes the first-line positioning of osimertinib- and lazertinib-based combination regimens and evaluates the clinical value of domestic third-generation tyrosine kinase inhibitors. In response to the NCCN's cautious stance on “conversion therapy” for initially unresectable disease, the article elaborates on China’s exploratory efforts and the evolving evidence base for conversion strategies utilizing programmed death receptor 1 (PD-1) inhibitors (e.g., tislelizumab, toripalimab). Furthermore, it clarifies the “dual-track” diagnostic approach distinguishing MET pathway mutations from protein overexpression. Aimed at aligning with China’s clinical context, this review seeks to offer clinicians a practical reference that synthesizes cutting-edge international perspectives with local applicability.

To address the growing challenge of an increasing number of elderly lung cancer patients amidst China's aging population and to fill the gap in quality control standards for surgical treatment in this special population, this study aimed to develop a standardized surgical evaluation system for elderly lung cancer patients tailored to China's national conditions. The system was established through a literature review, integrated the pathophysiological characteristics of elderly patients, and was constructed following review, feedback, and revision by experts from multiple thoracic surgery centers. Employing a 100-point scoring system, it comprises three primary domains: physical infrastructure and geriatric adaptability foundational conditions (10 points); management level and perioperative care models (20 points); and technical proficiency and clinical outcomes (70 points). The system places a strong emphasis on geriatric adaptability, proposing specific, quantifiable indicators for age-friendly facility modifications, control of elderly-specific complications, multidisciplinary collaboration, and standardized perioperative management. It provides a convenient and measurable assessment tool for quality control in the surgical treatment of elderly lung cancer in China, which is expected to promote the standardization and homogenization of diagnosis and treatment.

Sacroiliac complex injuries are commonly seen in high-energy pelvic fractures. The injuries make a big difference in treatment patterns due to the diverse injury types, posing considerable challenges in formulating optimal treatment strategies, and hence are persistent clinical difficulties in orthopedic trauma. The clinical management of sacroiliac complex injuries presents several key challenges such as a non-negligible rate of missed diagnoses in associated vascular and visceral injuries, absence of standardized protocols for surgical approaches and reduction-fixation strategies across different injury patterns, and ongoing controversies regarding surgical indications and optimal timing for patients combined with concomitant lumbosacral plexus injuries. Currently, no systematic clinical guidelines are available for the diagnosis and treatment of sacroiliac complex injuries both domestically and internationally. To this end, the Pelvic and Acetabular Surgery Group, Orthopedic Branch, China International Exchange and Promotive Association for Medical and Health Care and Orthopedic Physician Branch, Chinese Medical Doctor Association organized a panel of domestic experts in the field to develop the Clinical guideline for the diagnosis and treatment of sacroiliac complex injuries ( version 2025), based on evidence-based medicine and adhering to the principles of scientific rigor, clinical applicability, and innovation. These guidelines provided 11 recommendations covering diagnosis, therapeutic principles and techniques, management protocols for lumbosacral plexus injuries, outcome evaluation, and postoperative rehabilitation pathways, etc., aiming to standardize the clinical management of sacroiliac complex injuries.

Objective:To analyze the correlation between the recovery of postoperative function of hip joint in patient underwent total hip arthroplasty(THA)and anatomical parameters of femur under computed tomography(CT)three-dimensional(3D)reconstruction.Methods:From January 2022 to October 2024,a total of 120 THA patients were treated at the 904th Hospital of People's Liberation Army Joint Service Support Force were selected.At the third month post-surgery,the Harris Hip Score(HHS)system was used to assess the recovery of the function of hip joint of THA patients,and they were divided into favorable recovery group(72 cases,HHS score≥80)and poor recovery group(48 cases,HHS score<80).The femoral offset(FO),collodiaphyseal angle(CDA),and femoral neck anteversion(FNA)in anatomical parameters of femur under CT CD reconstruction for patients of two groups after surgery were measured and compared.The correlation between each parameter and the recovery of postoperative function of hip joint in THA patients was analyzed.The receiver operating characteristic(ROC)curve was plotted to analyze the assessment value of each parameter for the recovery of the function of hip joints in THA patients.Results:In the follow-up at the third month,120 patients were assessed by using the HHS scoring system.The recovery of 72 patients(60.00%)was favorable,with an average HHS score of 84.45±5.19.The recovery of 48 patients(40.00%)was poor,with an average HHS score of 73.31±4.78.Postoperative CDA and FO scores were higher than preoperative values,while FNA scores were lower than preoperative value in 120 patients.After surgery,the CDA and FO scores of favorable recovery group were lower than those of poor recovery group,and FNA was higher than that of favorable group,and the differences between the two groups were statistically significant(t=7.938,9.574,10.391,P<0.05).Pearson correlation coefficient test showed that postoperative function(HHS score)of hip joint negatively correlated with FNA in THA patients(r=-0.511,P<0.05),and it positively correlated with CDA and FO(r=0.408,0.359,P<0.05).ROC curve analysis indicated that the area under curve(AUC)values of ROC curves of single CDA,FO,FNA and the combined detection of them were respectively 0.761,0.855,and 0.827 in assessing the poor recovery of the function of hip joint,which had a certain of assessment values.The combined detection can improve the diagnostic value.Conclusion:The postoperative recovery of the function of hip joint of THA patients relates to CDA,FO and FNA parameters,and the single and combined detections of each parameter all have a certain of assessment value for the poor recovery of joints'function of patients.

Human amnion (hAM), as a biomaterial, has made significant progress in the field of ophthalmology, particularly in the treatment of retinal diseases. hAM possesses biological properties such as promoting tissue repair, inhibiting inflammation and neovascularization, and reducing fibrosis, which have led to its promising clinical outcomes in treating macular holes, retinal detachment, proliferative vitreoretinopathy, optic disc depression-related macular detachment, and age-related macular degeneration. The application of hAM can improve surgical success rates and promote vision recovery, with no significant rejection reactions observed due to its low immunogenicity. Nevertheless, the use of hAM still faces challenges in optimizing preparation and storage techniques, enhancing therapeutic efficacy, and reducing the risk of infectious disease transmission. Future research should focus on addressing these issues to further promote the application of hAM in retinal disease treatment and enhance its effectiveness.

Vascular cognitive impairment(VCI)is a syndrome of cognitive decline attributed to vascular risk factors and cerebrovascular diseases.A range of pathophysiological processes induced by vascular injury,including inflammation,oxidative stress,cell death,disruption of the blood-brain barrier,and synaptic damage are intricately linked to the development of VCI.Nuclear factor E2-related factor 2(Nrf2),encoded by the NFE2L2 gene,is a potent transcription factor that plays a critical role in antioxidant defense.Extensive research has demonstrated that Nrf2 mitigates oxidative stress and inflammation by upregulating the expression of antioxidant response elements,thereby reducing the production of reactive oxygen species.Nrf2 also modulates programmed cell death,enhances blood-brain barrier integrity,and promotes synaptic plasticity,ultimately delaying the progression of VCI.This review examines the role of Nrf2 in VCI and highlights recent research on traditional Chinese medicines targeting Nrf2 for the prevention and treatment of VCI,thus providing novel insights and approaches for managing this condition.

Objective: To investigate the potential therapeutic mechanisms of kaempferol , an active component in the traditional Chinese medicine gardenia , for lung cancer treatment using a network pharmacology approach . Methods: The main active ingredients and potential targets of Gardenia jasminoides were obtained through the Tra⁃ditional Chinese Medicine Pharmacology Database and Analysis Platform (TCMSP) , and combined with the lung cancer related target information collected from Gene Cards and OMIM databases , the intersection targets of Garde⁃nia jasminoides and lung cancer treatment were determined by drawing Venn diagrams . Further screening of core targets was conducted through PPI network analysis , and gene ontology (GO) function and Kyoto Encyclopedia of Genes and Genomes ( KEGG) pathway enrichment analysis were performed using the Metascape platform . Auto dock software was used to evaluate the binding affinity between the active ingredients of Gardenia jasminoides and target proteins . In terms of experiments , cell proliferation ability was evaluated through CCK⁃8 assay , cell migration and invasion ability were detected through cell scratch healing assay and Transwell assay , and the expression levels of epithelial mesenchymal transition ( EMT) protein and inflammatory factors were detected by Western blot and RT⁃qPCR . Results: The active ingredient kaempferol in Gardenia jasminoides exhibited significant binding ability invasion of lung cancer cells . The results of Western blot and RT⁃qPCR further confirmed that kaempferol could promote an increase in E ⁃cadherin , a decrease in N ⁃cadherin and Vimentin , and reduce the expression of inflam⁃matory factors . Conclusion The active ingredient of Gardenia jasminoides , kaempferol , inhibits the proliferation ,migration and invasion of lung cancer cells by targeting BCL⁃2 , while reversing EMT progression and suppressing the expression levels of inflammatory cytokines in lung cancer cells , thus preventing lung cancer progression .

Sacroiliac complex injuries are commonly seen in high-energy pelvic fractures. The injuries make a big difference in treatment patterns due to the diverse injury types, posing considerable challenges in formulating optimal treatment strategies, and hence are persistent clinical difficulties in orthopedic trauma. The clinical management of sacroiliac complex injuries presents several key challenges such as a non-negligible rate of missed diagnoses in associated vascular and visceral injuries, absence of standardized protocols for surgical approaches and reduction-fixation strategies across different injury patterns, and ongoing controversies regarding surgical indications and optimal timing for patients combined with concomitant lumbosacral plexus injuries. Currently, no systematic clinical guidelines are available for the diagnosis and treatment of sacroiliac complex injuries both domestically and internationally. To this end, the Pelvic and Acetabular Surgery Group, Orthopedic Branch, China International Exchange and Promotive Association for Medical and Health Care and Orthopedic Physician Branch, Chinese Medical Doctor Association organized a panel of domestic experts in the field to develop the Clinical guideline for the diagnosis and treatment of sacroiliac complex injuries ( version 2025), based on evidence-based medicine and adhering to the principles of scientific rigor, clinical applicability, and innovation. These guidelines provided 11 recommendations covering diagnosis, therapeutic principles and techniques, management protocols for lumbosacral plexus injuries, outcome evaluation, and postoperative rehabilitation pathways, etc., aiming to standardize the clinical management of sacroiliac complex injuries.

Objective:To analyze the correlation between the recovery of postoperative function of hip joint in patient underwent total hip arthroplasty(THA)and anatomical parameters of femur under computed tomography(CT)three-dimensional(3D)reconstruction.Methods:From January 2022 to October 2024,a total of 120 THA patients were treated at the 904th Hospital of People's Liberation Army Joint Service Support Force were selected.At the third month post-surgery,the Harris Hip Score(HHS)system was used to assess the recovery of the function of hip joint of THA patients,and they were divided into favorable recovery group(72 cases,HHS score≥80)and poor recovery group(48 cases,HHS score<80).The femoral offset(FO),collodiaphyseal angle(CDA),and femoral neck anteversion(FNA)in anatomical parameters of femur under CT CD reconstruction for patients of two groups after surgery were measured and compared.The correlation between each parameter and the recovery of postoperative function of hip joint in THA patients was analyzed.The receiver operating characteristic(ROC)curve was plotted to analyze the assessment value of each parameter for the recovery of the function of hip joints in THA patients.Results:In the follow-up at the third month,120 patients were assessed by using the HHS scoring system.The recovery of 72 patients(60.00%)was favorable,with an average HHS score of 84.45±5.19.The recovery of 48 patients(40.00%)was poor,with an average HHS score of 73.31±4.78.Postoperative CDA and FO scores were higher than preoperative values,while FNA scores were lower than preoperative value in 120 patients.After surgery,the CDA and FO scores of favorable recovery group were lower than those of poor recovery group,and FNA was higher than that of favorable group,and the differences between the two groups were statistically significant(t=7.938,9.574,10.391,P<0.05).Pearson correlation coefficient test showed that postoperative function(HHS score)of hip joint negatively correlated with FNA in THA patients(r=-0.511,P<0.05),and it positively correlated with CDA and FO(r=0.408,0.359,P<0.05).ROC curve analysis indicated that the area under curve(AUC)values of ROC curves of single CDA,FO,FNA and the combined detection of them were respectively 0.761,0.855,and 0.827 in assessing the poor recovery of the function of hip joint,which had a certain of assessment values.The combined detection can improve the diagnostic value.Conclusion:The postoperative recovery of the function of hip joint of THA patients relates to CDA,FO and FNA parameters,and the single and combined detections of each parameter all have a certain of assessment value for the poor recovery of joints'function of patients.

Objective To observe the effect of sevoflurane(SEV)on the expression of myocardial biological clock gene aromatic hydrocarbon receptor nuclear transport-like protein 1(BMAL1)in diabetic rats and to explore its changes.Methods Sixty healthy male SD rats with a body mass of 200-250 g were divided into oxygen inhalation group(NC)and sevoflurane inhalation group(SEV).The diabetic model was routinely replicated,and the model was divided into oxygen group(DM)and sevoflurane group(DM+SEV)with an inhalation time of 5 h(n=15).Four groups of experimental animals were executed at 0,12 and 24 h after the anesthesia was stopped and then myocardial tissue was isolated.Western blot was used to determine the expression level of biological clock gene BMAL1 protein and its activation enzyme USP9X;HE staining microspy to observe the pathological changes of my-ocardial tissue and immuno-fluorescence co-localization to observe the relationship between USP9X and BMAL1.Results At 0 and 12 h after stopping anesthesia,the expression of BMAL1 and USP9X in the DM+SEV group was significantly down-regulated as compared with the DM group,and the expression of BMAL1 and USP9X in the DM+SEV group was significantly down-regulated(P<0.05)at 24 h after stopping anesthesia(P>0.05).HE staining microscopy found changes of myocardial tissue structure in the DM+SEV group at 0 and 12 hrs after stopping anes-thesia.This change was most significant at 0 h after stopping anesthesia,but the myocardial tissue structure was neatly arranged at 24 h.The results of immuno-fluorescence colocalization showed that USP9X and BMAL1 proteins were mainly distributed in the cytoplasm of cardio-myocardium with and overlapping parts between them.Under the influence of sevoflurane,there was less overlap between the two at 0 and 12 hrs after stopping anesthesia and more overlap between the two at 24 h,which was close to that of the DM group.Conclusions Sevoflurane reversibly changes the expression of myocardial circadian clock gene BMAL1 in diabetic rats and this change still existe for 12 h after stopping anesthesia,then significantly fade away 24 hrs after stopping anesthesia.