Objective:To explore the relationship between coronary artery measurements combined with C-reactive protein(CRP), erythrocyte sedimentation rate(ESR) and coronary artery lesionsin(CAL) with incomplete Kawasaki disease (IKD) in children.Methods:Sixty-eight cases of pediatric IKD admitted to Huaibei Maternal and Child Health Care Hospital from January 2020 to April 2024 were selected as the IKD group, and 34 healthy children undergoing physical examination during the same period were selected as the control group according to the principle of 2∶1 pairing. Echocardiographic Z values including left coronary artery (LCA)-Z, right coronary artery (RCA)-Z, left anterior descending branch (LAD)-Z, left circumflex branch (LCX)-Z and CRP, ESR were compared between the two groups. General information of children with or without CAL were compared. The multivariate Logistic regression was used to screen the risk factors of IKD combined with CAL, and receiver operating characteristic (ROC) curve was used to analyze the predictive value of each index to IKD combined with CAL.Results:The LCA-Z, RCA-Z, LAD-Z, LCX-Z and the levels of CRP, ESR in the IKD group were higher than those in the control group: 3.26 ± 0.97 vs. 1.35 ± 0.28, 3.46 ± 0.92 vs. 1.01 ± 0.29, 3.18 ± 0.69 vs. 1.18 ± 0.34, 2.97 ± 0.68 vs.1.27 ± 0.34, (39.97 ± 9.03) mg/L vs. (4.21 ± 1.05) mg/L, (59.67 ± 16.34) mm/1 h vs. (12.85 ± 2.43) mm/1 h, there were statistical differences ( P<0.05). The duration of fever, intravenous immunoglobulin (IVIG) treatment response, IVIG start time, creatine kinase (CK), creatine kinase-MB(CK-MB), and N-terminal pro-B-type natriuretic peptide (NT-proBNP) between the children with IKD and CAL, IKD without CAL: (10.02 ± 2.45) d vs. (7.68 ± 1.43) d, 65.22%(15/23) vs. 88.89%(40/45), 60.87%(14/23) vs. 86.67%(39/45), (236.78 ± 59.74) U/L vs. (192.67 ± 35.41) U/L, (45.19 ± 9.85) U/L vs. (33.18 ± 9.87) U/L, (1.78 ± 0.32) μg/L vs. (0.92 ± 0.20) μg/L, there were statistical differences ( P<0.05). Logistic regression analysis showed that the duration of fever, IVIG treatment response, IVIG initiation time, CK, CK-MB, NT-proBNP, echocardiographic Z value, CRP and ESR levels were independent risk factors for IKD combined with CAL ( P<0.05). ROC curve analysis results showed that the area under the curve of IKD combined with CAL predicted by LCA-Z, RCA-Z, LADE-Z, LCX-Z, CRP and ESR was the largest, which was 0.917 (95% CI 0.824 - 0.970), which was higher than that diagnosed by each index alone ( P<0.05). Conclusions:There is a certain relationship between the echocardiographic Z values, CRP and ESR in children with IKD and CAL, which can be used to assist in the evaluation of IKD complicated with CAL.

Objective:To explore the relationship between coronary artery measurements combined with C-reactive protein(CRP), erythrocyte sedimentation rate(ESR) and coronary artery lesionsin(CAL) with incomplete Kawasaki disease (IKD) in children.Methods:Sixty-eight cases of pediatric IKD admitted to Huaibei Maternal and Child Health Care Hospital from January 2020 to April 2024 were selected as the IKD group, and 34 healthy children undergoing physical examination during the same period were selected as the control group according to the principle of 2∶1 pairing. Echocardiographic Z values including left coronary artery (LCA)-Z, right coronary artery (RCA)-Z, left anterior descending branch (LAD)-Z, left circumflex branch (LCX)-Z and CRP, ESR were compared between the two groups. General information of children with or without CAL were compared. The multivariate Logistic regression was used to screen the risk factors of IKD combined with CAL, and receiver operating characteristic (ROC) curve was used to analyze the predictive value of each index to IKD combined with CAL.Results:The LCA-Z, RCA-Z, LAD-Z, LCX-Z and the levels of CRP, ESR in the IKD group were higher than those in the control group: 3.26 ± 0.97 vs. 1.35 ± 0.28, 3.46 ± 0.92 vs. 1.01 ± 0.29, 3.18 ± 0.69 vs. 1.18 ± 0.34, 2.97 ± 0.68 vs.1.27 ± 0.34, (39.97 ± 9.03) mg/L vs. (4.21 ± 1.05) mg/L, (59.67 ± 16.34) mm/1 h vs. (12.85 ± 2.43) mm/1 h, there were statistical differences ( P<0.05). The duration of fever, intravenous immunoglobulin (IVIG) treatment response, IVIG start time, creatine kinase (CK), creatine kinase-MB(CK-MB), and N-terminal pro-B-type natriuretic peptide (NT-proBNP) between the children with IKD and CAL, IKD without CAL: (10.02 ± 2.45) d vs. (7.68 ± 1.43) d, 65.22%(15/23) vs. 88.89%(40/45), 60.87%(14/23) vs. 86.67%(39/45), (236.78 ± 59.74) U/L vs. (192.67 ± 35.41) U/L, (45.19 ± 9.85) U/L vs. (33.18 ± 9.87) U/L, (1.78 ± 0.32) μg/L vs. (0.92 ± 0.20) μg/L, there were statistical differences ( P<0.05). Logistic regression analysis showed that the duration of fever, IVIG treatment response, IVIG initiation time, CK, CK-MB, NT-proBNP, echocardiographic Z value, CRP and ESR levels were independent risk factors for IKD combined with CAL ( P<0.05). ROC curve analysis results showed that the area under the curve of IKD combined with CAL predicted by LCA-Z, RCA-Z, LADE-Z, LCX-Z, CRP and ESR was the largest, which was 0.917 (95% CI 0.824 - 0.970), which was higher than that diagnosed by each index alone ( P<0.05). Conclusions:There is a certain relationship between the echocardiographic Z values, CRP and ESR in children with IKD and CAL, which can be used to assist in the evaluation of IKD complicated with CAL.

Objective To investigate the predictive value of a nomogram model constructed based on imaging combined with prostate-specific antigen(PSA)and its related parameters for biopsy in patients with PSA levels of 4-10 ng/mL.Methods The serological and imaging data of 191 patients who were detected for PSA and related indicators and underwent the first biopsy of prostate by transrectal ultrasound at Zhongshan City People's Hospital and/or Yunfu Hospital of TCM from January 2018 to December 2023 were analyzed retrospectively.Multivariate Logistic regression identified independent risk factors for prostate cancer,and a nomogram model was developed for patients with PSA levels of 4-10 ng/mL.The predictive performance of the model was evaluated using receiver operating characteristic(ROC)curves,calibration curves,and decision curves.Results The multivariate Logistic regression analysis showed that free PSA,prostate volume,transition zone volume,PSA density,and the prostate imaging-reporting and data system(PI-RADS v2.1)score were independent risk factors for prostate cancer.The model incorporating these significant variables demonstrated the best performance,with an area under the curve(AUC)of 0.750(95%CI:0.678-0.821),sensitivity of 72.7%,specificity of 77.2%,and accuracy of 74.9%.The calibration curve indicated good agreement between the predicted probability and the actual probability of prostate cancer;and the decision curve analysis further confirmed that the model had high clinical utility.Conclusion The constructed nomogram prediction model can effectively estimate the preoperative risk of prostate cancer in patients with PSA levels of 4-10 ng/mL,providing clinicians with an intuitive tool to adjust treatment plans based on the assessed risk,thereby optimizing patient outcomes.

Objective To investigate the predictive value of a nomogram model constructed based on imaging combined with prostate-specific antigen(PSA)and its related parameters for biopsy in patients with PSA levels of 4-10 ng/mL.Methods The serological and imaging data of 191 patients who were detected for PSA and related indicators and underwent the first biopsy of prostate by transrectal ultrasound at Zhongshan City People's Hospital and/or Yunfu Hospital of TCM from January 2018 to December 2023 were analyzed retrospectively.Multivariate Logistic regression identified independent risk factors for prostate cancer,and a nomogram model was developed for patients with PSA levels of 4-10 ng/mL.The predictive performance of the model was evaluated using receiver operating characteristic(ROC)curves,calibration curves,and decision curves.Results The multivariate Logistic regression analysis showed that free PSA,prostate volume,transition zone volume,PSA density,and the prostate imaging-reporting and data system(PI-RADS v2.1)score were independent risk factors for prostate cancer.The model incorporating these significant variables demonstrated the best performance,with an area under the curve(AUC)of 0.750(95%CI:0.678-0.821),sensitivity of 72.7%,specificity of 77.2%,and accuracy of 74.9%.The calibration curve indicated good agreement between the predicted probability and the actual probability of prostate cancer;and the decision curve analysis further confirmed that the model had high clinical utility.Conclusion The constructed nomogram prediction model can effectively estimate the preoperative risk of prostate cancer in patients with PSA levels of 4-10 ng/mL,providing clinicians with an intuitive tool to adjust treatment plans based on the assessed risk,thereby optimizing patient outcomes.

Objective To analyze the short-term prognosis of two treatment methods for severe Cerebral venous sinus thrombosis (Cerebral Venous Sinus Thrombosis,CVST) and to explore the best treatment for severe CVST patients. Methods From January 2013 to January 2019,28 patients with severe cvst were diagnosed by neurosurgery in the first people’s hospital of Kunming. They were divided into two groups:simple internal anticoagulant therapy,anticoagulation and combined endovascular treatment. Results Anticoagulant combined with intravascular treatment group has a better short-term prognosis than that of medical anticoagulant group alone,the difference is statistically significant(P<0.05). Conclusions For patients with severe CVST,interventional therapy can be tried to improve the short-term prognosis.

Objective To compare the effects of ticagrelor and clopidogrel on platelet aggregation rate, myocardial perfusion and prognosis in patients with acute myocardial infarction. Methods One hundred and sixty-nine patients with acute ST segment elevation myocardial infarction (STEMI) and emergency percutaneous coronary intervention (PCI) were recruited and randomly divided into ticagrelor group (85 cases) and clopidogrel group (84 cases). The TIMI blood flow before and after PCI was recorded, and the ST segment fall rate of 1 h ECG after PCI was calculated. The platelet aggregation rate was measured. After 12 months' follow-up, the incidence of major adverse cardiac events (MACE) was recorded. The Logistic regression analysis was used to discover the factors of MACE. Results One hundred and sixty-nine patients with acute STEMI were recruited including 85 cases treated with ticagrelor and 84 cases in clopidogrel group. The ECG ST segment fall rate after PCI in ticagrelor group was significantly higher than that in clopidogrel group: (61.3 ± 30.7)％ vs. (47.8 ± 26.6)％, P<0.05. The platelet aggregation rate 2 h, 24 h and 7 d after PCI in ticagrelor group was significantly lower than that in clopidogrel group (P<0.05). MACE occurred in 19 cases (22.4％) in ticagrelor group and in 21 cases (25.0％) in clopidogrel group, and there was no significant difference (P > 0.05). Multiple Logistic regression analysis revealed that age and ECG ST segment fall rate were independent risk factors for MACE (P<0.05). Conclusions Compared with clopidogrel, ticagrelor can effectively reduce platelet aggregation rate and accelerate ST segment fall in STEMI patients, but their long-term prognosis is similar.

Objective To explore the change and clinical significance of the serum carcinoembryonic antigen (CEA)and carbohydrate antigen 724(CA724)in patients with rectal cancer before and after neoadjuvant ra-diotherapy and chemotherapy.Methods The serum levels of CEA and CA724 of 30 patients with rectal carci-noma were detected by electrochemiluminescence method and were compared with those in 30 healthy people. Results The serum levels of CEA and CA724 in rectal carcinoma patients before neoadjuvant radiotherapy and chemotherapy were significantly higher than those in the healthy people,the difference was statistically significant(P<0.05).The serum levels in complete remission and partial remission patients after eight-week neoadjuvant radiotherapy and chemotherapy were significantly lower than those before treatment,the differ-ence was statistically significant(P<0.05),and the reduction levels were obviously higher than those in the stable group,the difference was statistically significant(P< 0.05).The CEA and CA724 levels in the stable treatment patients were also lower than those of before neoadjuvant radiotherapy and chemotherapy,the difference was statistically significant(P<0.05).The serum levels in the progression group were higher than those of before treatment(P<0.05).The serum levels of CEA and CA724 before neoadjuvant radiotherapy and chemotherapy existed a positive correlation(r=0.862,P=0.000).Conclusion The serum levels of CEA and CA724 in rectal cancer are highly expressed,suggesting that both of them are closely related to the occur-rence and development of rectal carcinoma,the measurement of the serum level changes of CEA and CA724 in patients with rectal cancer before and after treatment contributes to estimate the efficacy of neoadjuvant radio-therapy and chemotherapy and tumor progression.

Objective To investigate the predictive value of serum adiponectin level on morbidity of acute myocardial infarction, and to evaluate its impact on prognosis in patients with acute myocardial infarction after percutaneous coronary intervention (PCI). Methods We prospectively recruited patients with acute ST segment elevation myocardial infarction (STEMI) who had underwent primary PCI. Their serum adiponectin levels were measured. The TIMI blood flow classification of culprit vessel was recorded after PCI. Echocardiography was performed in 24 h after PCI to evaluate left ventricular ejection fraction (LVEF). Major adverse cardiac events (MACE) were recorded including cardiac death, recurrent nonfatal myocardial infarction, target vessel reascularization, and readmission for heart failure after 18 months′ followed-up. Results 108 consecutive patients with STEMI and 38 control patients without coronary artery stenosis were recruited. The serum adiponectin level in STEMI group was significantly lower than that in control: (1 413.9 ± 218.8) ng/L vs.(1 756.3 ± 205.5) ng/L (P<0.01). STEMI patients with LVEF < 50% had lower serum adiponectin level compared with LVEF ≥50%: (1 334.1 ± 226.3) ng/L vs. (1 453.0 ± 213.8) ng/L , P<0.01. The serum adiponectin level in the TIMI 0-2 group after PCI was significantly lower than that in the TIMI 3 group:(1 350.7 ± 214.9) ng/L vs. (1 430.6 ± 218.5) ng/L, P < 0.01. Multiple logistic regression analysis revealed that lower serum adiponectin level was an independent predictor of STEMI ( OR=0.992, 95% CI 0.987-0.996, P<0.01). MACE occurred in 22 patients (20.4% ). Cox regression analysis revealed that lower serum adiponectin level remained an independent predictor of MACE ( OR=0.996, 95% CI 0.993-0.999, P < 0.01). Conclusions Lower serum adiponectin level is significantly associated with morbidity of STEMI and adverse prognosis in patients with acute myocardial infarction.

Objective To explore the prognostic value of ventricular wall motion score (WMS) and left ventricular ejection fraction (LVEF) in patients with acute myocardial infarction (AMI) combined with heart failure (HF) in the recent 12 months Methods We selected hospitalized AMI patients in our department from Jan. 2014 to Nov. 2014. Cardiac ultrasound was performed to detect WMS and LVEF within 48 hours and during the 6?month follow?up period and the occurrence of HF was recorded. Results Totally 127 AMI patients were recruited, including 20 cases combined with HF. The WMS was higher in HF group than those in non?HF group (23.55 ± 3.73 vs 20.11 ± 3.13, P<0.01), while the LVEF in HF group was lower than those in non?HF group (48.77 ± 8.08 vs 56.99 ± 5.17, P<0.01). Multiple logistic regression analysis revealed that WMS and LVEF were both independent predictors of HF in the recent 12 months (P < 0.05). The prediction effect of WMS ROC curve area was 0.81 (P < 0.01) , and LVEF 0.76 (P < 0.05). WMS and LVEF combined assessment area under ROC curve was 0.82 (P < 0.01). Conclusion WMS and LVEF are independent predictors of HF in patients with AMI in the recent 12 months and the combined application of WMS and LVEF can significantly improve the prediction effect.

Objective To investigate the effects of tripterygium glycosides combined with methotrexate in treatment of rheumatoid arthritis (RA) curative effect and peripheral blood of patients with IL-6, effects of IL-10 and TNF- alpha. Methods 80 patients with RA from February 2014 to August 2016 in our hospital were retrospectively analyzed. According to the different treatment methods by for the observation group, the control group (40 cases). To compare and analyze the curative effect before and after short-term treatment and treatment of patients in the 2 groups were the main clinical symptoms and signs of change and ESR, RF, CRP, IL-6, TNF- alpha, IL-10 index. Results The total effective rate of observation group (92.50％) was significantly higher than the control group (77.50％), the difference was statistically significant (P<0.05), 2 groups of patients before treatment of main clinical symptoms and signs, there was no significant difference, after treatment, clinical symptoms and signs of 2 groups of patients were compared with those before treatment was statistically significant to alleviate the differences (P<0.05), and the observation group of main clinical symptoms and signs were lower than the control group and the remission (down), the difference was statistically significant (P<0.05).Before ESR, the treatment of 2 patients with RF, CRP, TNF- IL-6, alpha, IL-10 index level, no statistical significance, the 2 groups after treatment in patients with ESR, RF, CRP, IL-6, TNF- alpha, IL-10 index level than before treatment with significant difference (P<0.05), and the observation group ESR, RF, CRP, TNF- alpha, IL-6 average index of water compared with the control group decreased significantly, IL-10 index increased significantly than the control group. The difference was statistically significant (P<0.05). Conclusion Tripterygium glycosides combined with methotrexate in treatment of rheumatoid arthritis And it can effectively inhibit the expression of peripheral serum L-6 and TNF- alpha, promote the expression of IL-10 and alleviate the inflammatory reaction