1.Erratum: Diagnostic challenges in the assessment of thyroid neoplasms using nuclear features and vascular and capsular invasion: a multi-center interobserver agreement study
Agnes Stephanie HARAHAP ; Mutiah MUTMAINNAH ; Maria Francisca HAM ; Dina KHOIRUNNISA ; Abdillah HASBI ASSADYK ; Husni CANGARA ; Aswiyanti ASRI ; Diah Prabawati RETNANI ; Fairuz QUZWAIN ; Hasrayati AGUSTINA ; Hermawan ISTIADI ; Indri WINDARTI ; Krisna MURTI ; Muhammad TAKBIR ; Ni Made MAHASTUTI ; Nila KURNIASARI ; Nungki ANGGOROWATI ; Pamela ABINENO ; Yulita Pundewi SETYORINI ; Kennichi KAKUDO
Journal of Pathology and Translational Medicine 2025;59(3):201-201
2.Erratum: Diagnostic challenges in the assessment of thyroid neoplasms using nuclear features and vascular and capsular invasion: a multi-center interobserver agreement study
Agnes Stephanie HARAHAP ; Mutiah MUTMAINNAH ; Maria Francisca HAM ; Dina KHOIRUNNISA ; Abdillah HASBI ASSADYK ; Husni CANGARA ; Aswiyanti ASRI ; Diah Prabawati RETNANI ; Fairuz QUZWAIN ; Hasrayati AGUSTINA ; Hermawan ISTIADI ; Indri WINDARTI ; Krisna MURTI ; Muhammad TAKBIR ; Ni Made MAHASTUTI ; Nila KURNIASARI ; Nungki ANGGOROWATI ; Pamela ABINENO ; Yulita Pundewi SETYORINI ; Kennichi KAKUDO
Journal of Pathology and Translational Medicine 2025;59(3):201-201
3.Erratum: Diagnostic challenges in the assessment of thyroid neoplasms using nuclear features and vascular and capsular invasion: a multi-center interobserver agreement study
Agnes Stephanie HARAHAP ; Mutiah MUTMAINNAH ; Maria Francisca HAM ; Dina KHOIRUNNISA ; Abdillah HASBI ASSADYK ; Husni CANGARA ; Aswiyanti ASRI ; Diah Prabawati RETNANI ; Fairuz QUZWAIN ; Hasrayati AGUSTINA ; Hermawan ISTIADI ; Indri WINDARTI ; Krisna MURTI ; Muhammad TAKBIR ; Ni Made MAHASTUTI ; Nila KURNIASARI ; Nungki ANGGOROWATI ; Pamela ABINENO ; Yulita Pundewi SETYORINI ; Kennichi KAKUDO
Journal of Pathology and Translational Medicine 2025;59(3):201-201
4.Strengthening cross-regional networks: evaluation of Indonesia's national Early Warning Alert and Response System by field epidemiology training programmes from Indonesia and Japan, 2023
Keiko Tsukada ; Irma Gusmi Ratih ; Shingo Nishiki ; Munehisa Fukusumi ; Atik Choirul Hidajah ; Fransisca Susilastuti ; Anak Agung Sagung Sawitri ; I Wayan Sugihana Aradea ; Tri Yunis Miko Wahyono ; Helda ; Dwi Sutiningsih ; Nissa Kusariana ; Bayu Satria Wiratama ; Sugiarto ; Indra Dwinata ; Oderna ; Isamu Kuboki ; Rizki Dinar Winiar ; Risky Ayunni ; Nur Assyifa Daiyah Fillah ; Eka Muhiriyah ; Yulia Zubir ; Emita Ajis ; Cepi Irawansyah ; Crysti Mei Manik ; Firda Aisya ; Husni ; Orina Melisa Nasution ; Tomimasa Sunagawa ; Triya Novita Dinihari
Western Pacific Surveillance and Response 2025;16(3):01-04
The field epidemiology training programmes (FETPs) of Indonesia and Japan collaboratively conducted a surveillance evaluation in Indonesia following universal guidelines. This experience could serve as a meaningful milestone with potential applications for FETPs in other countries, thereby strengthening the FETP network and ultimately enhancing global health security.
5.Diagnostic challenges in the assessment of thyroid neoplasms using nuclear features and vascular and capsular invasion: a multi-center interobserver agreement study
Agnes Stephanie HARAHAP ; Mutiah MUTMAINNAH ; Maria Francisca HAM ; Dina KHOIRUNNISA ; Abdillah Hasbi ASSADYK ; Husni CANGARA ; Aswiyanti ASRI ; Diah Prabawati RETNANI ; Fairuz QUZWAIN ; Hasrayati AGUSTINA ; Hermawan ISTIADI ; Indri WINDARTI ; Krisna MURTI ; Muhammad TAKBIR ; Ni Made MAHASTUTI ; Nila KURNIASARI ; Nungki ANGGOROWATI ; Pamela ABINENO ; Yulita Pundewi SETYORINI ; Kennichi KAKUDO
Journal of Pathology and Translational Medicine 2024;58(6):299-309
Background:
The diagnosis of thyroid neoplasms necessitates the identification of distinct histological features. Various education/hospital centers located in cities across Indonesia likely result in discordances among pathologists when diagnosing thyroid neoplasms.
Methods:
This study examined the concordance among Indonesian pathologists in assessing nuclear features and capsular and vascular invasion of thyroid tumors. Fifteen pathologists from different centers independently assessed the same 14 digital slides of thyroid tumor specimens. All the specimens were thyroid neoplasms with known BRAFV600E and RAS mutational status, from a single center. We evaluated the pre- and post-training agreement using the Fleiss kappa. The significance of the training was evaluated using a paired T-test.
Results:
Baseline agreement on nuclear features was slight to fair based on a 3-point scoring system (k = 0.14 to 0.28) and poor to fair based on an eight-point system (k = –0.02 to 0.24). Agreements on vascular (κ = 0.35) and capsular invasion (κ = 0.27) were fair, whereas the estimated molecular type showed substantial agreement (κ = 0.74). Following the training, agreement using the eight-point system significantly improved (p = 0.001).
Conclusions
The level of concordance among Indonesian pathologists in diagnosing thyroid neoplasm was relatively poor. Consensus in pathology assessment requires ongoing collaboration and education to refine diagnostic criteria.
6.The agreement of panoramic radiography with cone-beam computed tomography in classifying impacted lower third molars: a systematic review
Husni MUBARAK ; Andi TAJRIN ; Nurwaida
Archives of Craniofacial Surgery 2024;25(6):263-269
Background:
This systematic review aimed to determine whether cone-beam computed tomography (CBCT) and panoramic radiography (PR) yield consistent results in determining the degree of impacted lower third molar teeth based on existing classification parameters.
Methods:
A comprehensive literature search was conducted of PubMed, Embase, Cochrane, and PLOS One, adhering to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Additionally, a manual search was also carried out. There were no restrictions on publication dates, allowing a broader scope of literature. Only articles published in English were eligible for inclusion. Furthermore, all studies that compared the outcomes of CBCT and panoramic images concerning the position of impacted teeth, according to the Winter and the Pell & Gregory classifications, were included.
Results:
Four studies met the inclusion criteria. One study used the Pell & Gregory classification to assess differences, finding a significant result (P< 0.001). Two studies used both the Winter and the Pell & Gregory classifications. In these assessments, one study found no significant differences in the Winter classification (p= 1.000) or the Pell & Gregory assessment (p= 0.500). However, another study identified significant differences using both the winter and the Pell & Gregory classifications (P< 0.001). One study conducted an assessment using only Winter classification and found no significant differences between PR and CBCT (P> 0.05).
Conclusion
There are inter-modality differences in the agreement concerning the degree of impaction of the third molar when using CBCT compared with panoramic imaging across various classification levels. Improved assessment methods are necessary to determine the most appropriate imaging modality for therapeutic management.
7.The agreement of panoramic radiography with cone-beam computed tomography in classifying impacted lower third molars: a systematic review
Husni MUBARAK ; Andi TAJRIN ; Nurwaida
Archives of Craniofacial Surgery 2024;25(6):263-269
Background:
This systematic review aimed to determine whether cone-beam computed tomography (CBCT) and panoramic radiography (PR) yield consistent results in determining the degree of impacted lower third molar teeth based on existing classification parameters.
Methods:
A comprehensive literature search was conducted of PubMed, Embase, Cochrane, and PLOS One, adhering to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Additionally, a manual search was also carried out. There were no restrictions on publication dates, allowing a broader scope of literature. Only articles published in English were eligible for inclusion. Furthermore, all studies that compared the outcomes of CBCT and panoramic images concerning the position of impacted teeth, according to the Winter and the Pell & Gregory classifications, were included.
Results:
Four studies met the inclusion criteria. One study used the Pell & Gregory classification to assess differences, finding a significant result (P< 0.001). Two studies used both the Winter and the Pell & Gregory classifications. In these assessments, one study found no significant differences in the Winter classification (p= 1.000) or the Pell & Gregory assessment (p= 0.500). However, another study identified significant differences using both the winter and the Pell & Gregory classifications (P< 0.001). One study conducted an assessment using only Winter classification and found no significant differences between PR and CBCT (P> 0.05).
Conclusion
There are inter-modality differences in the agreement concerning the degree of impaction of the third molar when using CBCT compared with panoramic imaging across various classification levels. Improved assessment methods are necessary to determine the most appropriate imaging modality for therapeutic management.
8.Diagnostic challenges in the assessment of thyroid neoplasms using nuclear features and vascular and capsular invasion: a multi-center interobserver agreement study
Agnes Stephanie HARAHAP ; Mutiah MUTMAINNAH ; Maria Francisca HAM ; Dina KHOIRUNNISA ; Abdillah Hasbi ASSADYK ; Husni CANGARA ; Aswiyanti ASRI ; Diah Prabawati RETNANI ; Fairuz QUZWAIN ; Hasrayati AGUSTINA ; Hermawan ISTIADI ; Indri WINDARTI ; Krisna MURTI ; Muhammad TAKBIR ; Ni Made MAHASTUTI ; Nila KURNIASARI ; Nungki ANGGOROWATI ; Pamela ABINENO ; Yulita Pundewi SETYORINI ; Kennichi KAKUDO
Journal of Pathology and Translational Medicine 2024;58(6):299-309
Background:
The diagnosis of thyroid neoplasms necessitates the identification of distinct histological features. Various education/hospital centers located in cities across Indonesia likely result in discordances among pathologists when diagnosing thyroid neoplasms.
Methods:
This study examined the concordance among Indonesian pathologists in assessing nuclear features and capsular and vascular invasion of thyroid tumors. Fifteen pathologists from different centers independently assessed the same 14 digital slides of thyroid tumor specimens. All the specimens were thyroid neoplasms with known BRAFV600E and RAS mutational status, from a single center. We evaluated the pre- and post-training agreement using the Fleiss kappa. The significance of the training was evaluated using a paired T-test.
Results:
Baseline agreement on nuclear features was slight to fair based on a 3-point scoring system (k = 0.14 to 0.28) and poor to fair based on an eight-point system (k = –0.02 to 0.24). Agreements on vascular (κ = 0.35) and capsular invasion (κ = 0.27) were fair, whereas the estimated molecular type showed substantial agreement (κ = 0.74). Following the training, agreement using the eight-point system significantly improved (p = 0.001).
Conclusions
The level of concordance among Indonesian pathologists in diagnosing thyroid neoplasm was relatively poor. Consensus in pathology assessment requires ongoing collaboration and education to refine diagnostic criteria.
9.The agreement of panoramic radiography with cone-beam computed tomography in classifying impacted lower third molars: a systematic review
Husni MUBARAK ; Andi TAJRIN ; Nurwaida
Archives of Craniofacial Surgery 2024;25(6):263-269
Background:
This systematic review aimed to determine whether cone-beam computed tomography (CBCT) and panoramic radiography (PR) yield consistent results in determining the degree of impacted lower third molar teeth based on existing classification parameters.
Methods:
A comprehensive literature search was conducted of PubMed, Embase, Cochrane, and PLOS One, adhering to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Additionally, a manual search was also carried out. There were no restrictions on publication dates, allowing a broader scope of literature. Only articles published in English were eligible for inclusion. Furthermore, all studies that compared the outcomes of CBCT and panoramic images concerning the position of impacted teeth, according to the Winter and the Pell & Gregory classifications, were included.
Results:
Four studies met the inclusion criteria. One study used the Pell & Gregory classification to assess differences, finding a significant result (P< 0.001). Two studies used both the Winter and the Pell & Gregory classifications. In these assessments, one study found no significant differences in the Winter classification (p= 1.000) or the Pell & Gregory assessment (p= 0.500). However, another study identified significant differences using both the winter and the Pell & Gregory classifications (P< 0.001). One study conducted an assessment using only Winter classification and found no significant differences between PR and CBCT (P> 0.05).
Conclusion
There are inter-modality differences in the agreement concerning the degree of impaction of the third molar when using CBCT compared with panoramic imaging across various classification levels. Improved assessment methods are necessary to determine the most appropriate imaging modality for therapeutic management.
10.Diagnostic challenges in the assessment of thyroid neoplasms using nuclear features and vascular and capsular invasion: a multi-center interobserver agreement study
Agnes Stephanie HARAHAP ; Mutiah MUTMAINNAH ; Maria Francisca HAM ; Dina KHOIRUNNISA ; Abdillah Hasbi ASSADYK ; Husni CANGARA ; Aswiyanti ASRI ; Diah Prabawati RETNANI ; Fairuz QUZWAIN ; Hasrayati AGUSTINA ; Hermawan ISTIADI ; Indri WINDARTI ; Krisna MURTI ; Muhammad TAKBIR ; Ni Made MAHASTUTI ; Nila KURNIASARI ; Nungki ANGGOROWATI ; Pamela ABINENO ; Yulita Pundewi SETYORINI ; Kennichi KAKUDO
Journal of Pathology and Translational Medicine 2024;58(6):299-309
Background:
The diagnosis of thyroid neoplasms necessitates the identification of distinct histological features. Various education/hospital centers located in cities across Indonesia likely result in discordances among pathologists when diagnosing thyroid neoplasms.
Methods:
This study examined the concordance among Indonesian pathologists in assessing nuclear features and capsular and vascular invasion of thyroid tumors. Fifteen pathologists from different centers independently assessed the same 14 digital slides of thyroid tumor specimens. All the specimens were thyroid neoplasms with known BRAFV600E and RAS mutational status, from a single center. We evaluated the pre- and post-training agreement using the Fleiss kappa. The significance of the training was evaluated using a paired T-test.
Results:
Baseline agreement on nuclear features was slight to fair based on a 3-point scoring system (k = 0.14 to 0.28) and poor to fair based on an eight-point system (k = –0.02 to 0.24). Agreements on vascular (κ = 0.35) and capsular invasion (κ = 0.27) were fair, whereas the estimated molecular type showed substantial agreement (κ = 0.74). Following the training, agreement using the eight-point system significantly improved (p = 0.001).
Conclusions
The level of concordance among Indonesian pathologists in diagnosing thyroid neoplasm was relatively poor. Consensus in pathology assessment requires ongoing collaboration and education to refine diagnostic criteria.


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