1.HLA class I alleles and haplotypes in Chinese patients with primary biliary cirrhosis.
Dantong ZHAO ; Huiyu LIAO ; Xin ZHANG ; Yanmin LIU ; Haiping ZHANG ; Chunyang HUANG ; Limei SUN ; Huiping YAN
Chinese Journal of Hepatology 2014;22(12):904-909
OBJECTIVETo analyze the HLA class I alleles and haplotypes in Chinese patients with primary biliary cirrhosis (PBC).
METHODSSequencing based typing-polymerase chain reaction (SBT-PCR) was used to investigate the HLA class I alleles of 146 PBC patients and 500 normal controls in northern China. The frequencies of alleles and haplotypes were calculated and compared for the two groups. The chi-square test and Fisher's exact test were used for statistical analyses.
RESULTSThere were 26, 51 and 21 alleles identified at the HLA-A, B and C loci respectively, and the frequencies of these alleles were not significantly different between the PBC and normal control groups.However, the frequencies of A *11:01-B*40:06 and A*02:01-B*l5:01 haplotypes were significantly higher in the PBC group than in the normal control group (7.53% vs. 1.40%, P<0.01, OR=5.38; 6.85% vs. 2.00%, P=0.003, OR=3.425).
CONCLUSIONThis study established the role of HLA class I haplotypes in determining PBC susceptibility in a Chinese population.
Alleles ; Asian Continental Ancestry Group ; China ; Gene Frequency ; Haplotypes ; Histocompatibility Antigens Class I ; Humans ; Liver Cirrhosis, Biliary ; Polymerase Chain Reaction
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