Background: Preeclampsia is a complex disease caused by pregnancy, with many complications for both mother and fetus, but there is no specific treatment. The purpose of the study is to describe clinical characteristics and survey some risk factors for preeclampsia. Materials and methods: The case-control study included 205 pregnant women with preeclampsia and 205 pregnant women without preeclampsia. Results: In the preeclampsia group, systolic blood pressure, diastolic blood pressure and BMI were 154.9 ± 15.5 mmHg, 96.0 ± 9.7 mmHg and 23.7 ± 3.5 kg/m2, respectively; edema (58.5%), history of preeclampsia (14.1%), early-onset preeclampsia (28.8%) and severe preeclampsia (42.4%). Early onset increased the risk of severe preeclampsia with OR = 3.98 (95% CI: 2.10 - 7.55). 10.8% had complications, in the mother including HELLP syndrome, eclampsia, coagulation disorders and in the fetus including fetal distress, intrauterine growth retardation and premature birth. Maternal age ≥ 35 years old, history of miscarriage, BMI were associated with preeclampsia, with OR 3.36 (95% CI: 2.06 - 5.46); 1.67 (95% CI: 1.04 - 2.67); 6.66 (95% CI: 4.19 - 10.59), respectively. Conclusion: Severe preeclampsia accounted for a high rate, was associated with early onset, and complications were recorded in both mother and fetus. Maternal age, history of miscarriage and overweight were factors that increase the risk of preeclampsia.

Background: The VEGFA gene encodes vascular endothelial growth factor A (VEGF-A), which plays a key role in vasculogenesis and angiogenesis. The VEGFA rs3025039 (+936C>T) polymorphism is associated with many diseases. This study aimed to: (1) Apply PCR-RFLP technique to identify the VEGFA rs3025039 (+936C>T) polymorphism; (2) Primarily evaluate the distribution of genotypes and allele frequencies of the rs3025039 polymorphism in volunteers. Materials and methods: DNA extraction was isolated from peripheral blood of 60 volunteers. Determining the VEGFA rs3025039 (+936C>T) polymorphism by PCR-RFLP technique. Confirming the results of the genotypes randomly by Sanger sequencing. Results: All PCR-RFLP results of validated samples were in concordance with sequencing results. The distribution of CC, CT and TT genotypes by rs3025039 polymorphism accounted for 80%, 16.7% and 3.3%, respectively. The frequencies of C and T alleles were 88.3% and 11.7%, respectively. Conclusion: Successfully applying PCR-RFLP technique to determine the VEGFA rs3025039 (+936C>T) polymorphism, which establishes the groundwork for further research into the association between this polymorphism and various disorders.

Objectives: Asymptomatic infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and test re-positivity after a negative test have raised concerns about the ability to effectively control the coronavirus disease 2019 (COVID-19) pandemic. We aimed to investigate the prevalence of COVID-19 asymptomatic and pre-symptomatic infections during the second wave of COVID-19 in Viet Nam, and to better understand the duration of SARS-CoV-2 infection and the dynamics between the evolution of clinical symptoms and SARS-CoV-2 test positivity among confirmed COVID-19 cases. Methods: We conducted a cohort analysis on the first 50 confirmed cases during the second COVID-19 wave in Viet Nam using clinical, laboratory and epidemiological data collected from 9 March to 30 April 2020. Kaplan-Meier estimates were used to assess time to clearance of SARS-CoV-2 infection, and log-rank tests were used to explore factors related to time to SARS-CoV-2 infection clearance. Results: Most cases (58%) had no typical signs or symptoms of COVID-19 at the time of diagnosis. Ten cases (20%) were re-positive for SARS-CoV-2 during infection. Eight cases (16%) experienced COVID-19 symptoms after testing negative for SARS-CoV-2. The median duration from symptom onset until clearance of infection was 14 days (range: 6–31); it was longer in re-positive and older patients and those with pre-existing conditions. Conclusion Asymptomatic and pre-symptomatic infections were common during the second wave of COVID-19 in Viet Nam. Re-positivity was frequent during hospitalization and led to a long duration of SARS-CoV-2 infection.

Background: Breast cancer is typically detected in women with a standard prevalence categorized by age of 80.1/100.000 people in the world. In Vietnam, the proportion for women was 17.4/100.000 people in 2000. The value of ultrasound has been acknowledged in the last few decades. However, there is an existing problem related to the proportion of inaccurate diagnosis (amounted to 10-20%), or suspect diagnosis. Thus, the diagnosis of breast cancer employing ultrasound (US) method not only overcomes the above obstacles, but also generates a number of advantages. \r\n', u'Objectives: To study the value of US and US lesions in the diagnostic for breast cancer. \r\n', u'Subjects and method: 621 patients with breast abnormalities were diagnosed and treated at K-hospital from 2003 to 2006. They underwent breast US scanning. The sonographic features were compared with pathologic results. \r\n', u'Results: Common signals of breast cancer: the mass of irregular shape: Se = 73.9%, Sp = 87; speculation margins: Se = 72.4%, Sp = 96.8%; hypoechoic mass: Se = 89.5%, Sp = 83.3%; heteroechoic density: Se = 98%, Sp = 68.5%. Other uncommon signals are: punctuate hyperechogenics of calcifications, acoustic shadow behinds the mass, the number of punctuate hyperechogenic > 5. The D/W index > 1: PPV = 95.9%. \r\n', u'Conclusion: Ultrasound is a valuable method for breast cancer diagnosis with Se = 89.47%, Sp = 86.49%, PPV = 92.96%, NPV = 83.72% and Acc = 88.41%.\r\n', u'
Breast cancer ; diagnosis ; Sonography

Descriptive study was carried out on 66 patients with pancreas head tumors diagnosed clinically, who underwent CT scanning and were treated surgically at Viet Duc Hospital. Ultrasound values were evaluated through the results of operation and pathological anatomy. CT scanning had achieved sensitivity of 96.8% and an accuracy of 90.9% in the diagnosis of the tumors. These values attained 52.3% and 66.7% in the detection of infiltrative signs in neighbouring organs and 75.0% and 90.9% in vessel infiltration. CT scanning was limited in the diagnosis of glandular metastasis and liver metastasis of tumors at pancreas head
Neoplasms ; Pancreas ; diagnosis ; Therapeutics ; surgery ; Tomography, X-Ray Computed

A comparative descriptive study was carried out on 80 patients diagnosed as pancrea head tumors. Ultrasound results were evaluated through operated and histopathological outcomes. Ultrasound diagnosis reached 96.1% of sensivity and 92.5% of accurracy, concerning the localization of the tumors the accuracy was 68%. Ultrasound sensitivity in the identification of the signs of infiltration in the neighbour tissues, in blood vessels, in gland was 12.5%, 11.8% and 8.8% respectively.
neoplasms ; Pancreatic Diseases ; Pancreatic Neoplasms ; ultrasonography ; diagnosis

A retrospective study on 55 subjects with surrenal gland tumors diagnosed by CT showed that the tumors are commonly benign and pheocromocytoma was detected lately with a large size (> 3 cm, accounted for 73.5%). Heterogenous structure of the tumors before and after the injection of the contrasts showed characterustic sign of pheocromocytoma. The CT procedure has had a sensitivity of 100% and a positive predictive value of 89%. In the diagnosis of ganglion metastasis, these ratios were 2/3 and 99% respectively, in the evaluation of infiltration into the liver and the right kidney, these ratios were 58.30% and 95% respectively
Tomography, X-Ray Computed ; Neoplasms ; methods

From April 1998 to June 2001, ultrasound had diagnosed the tumors at the pancrea head in 80 patients and they were operated at Viet Duc Hospital. Among these subjects, there were 43 tumors of pancrea head, 14 tumors of inferior part of common bile duct, 18 tumors ooffvater ampulla, 2 tumors of duodenal, 2 chronical pancreatitis and 1 unspecific fibroma of liver external bile duct. Among 77 patients of tumor of pancrea head definitely diagnosed, there are 3 falsely positive cases and 3 negative cases by ultrasound. In 48 patients invasive structures in vessal bundle of superior mesenteriolum were diagnosed by surgery. Thus detecting pancrea head tumors, ultrasonic technique is a convenient and simple method with a sensibility of 96.1%
Pancreas ; Pancreatic Neoplasms ; ultrasonography ; diagnosis

A retrospective study on 7 patients with close renal trauma was carried out. The preoperative and postoperative ultrasound found that the patients experienced the renal pedicular lesion. 7/7 patients were in stable condition, and experienced the urination with diluted blood or without blood. 7/7 patients had ultrasonic images of mass blood clot in the postperitoneal that push the kidney into the front. The CT scanner can suggest the renal pedicular lesion. If there was the renal pedicular lesion in the CT scanner image, it should implement renal angiography.
Diagnostic Imaging ; Ultrasonography

A retrospective study on the 77 patients suspected the cerebral vascular lesions received the ultrasound Doppler and angiography to evaluated the stenosid of carotid of which 154 rounds of ultrasound and angiography for outer, inner and bifurcation of carotid. The results have shown that there was suitability between ultrasound and angiography in 100% cases of complete stenosid or nearly embolised stenosid. The false positive results of ultrasound occurred in 9 rounds for inner carotid stenosid, 4 rounds for outer carotid stenosid and 2 rounds for bifurcation of carotid. The false negative results occurred in the inner carotid, outer carotid and bifurcation of carotid was 5, 2 and 12 rounds.
Carotid Stenosis ; Ultrasonography ; Angiography