OBJECTIVE:To observe the efficacy and safety of paclitaxel combined with cisplatin and fluorouracil for gastric cancer with liver metastases via indwelling hepatic arterial catheter. METHODS:56 gastric cancer patients with liver metastases were randomly divided into control group(28 cases)and observation group(28 cases). Control group received Paclitaxel injection 135 mg/m2,d1+Cisplatin injection 75 mg/m2,d1+Fluorouracil injection 750 mg/m2,d1-5,pumping administrated via central venous. Ob-servation group received Paclitaxel injection 135 mg/m2,d1+Cisplatin injection 75 mg/m2,d1+Fluorouracil injection 750 mg/m2,d1-5, administrated via indwelling hepatic arterial catheter. 3-4 weeks were a course,it lasted 8 courses at most. Magnesium isoglycyrrhiz-inate injection 200 mg/d was intravenously infused for liver protection in 2 groups during treatment. Clinical efficacy,serum car-cinoembryonic antigen (CEA),alanine aminotransferase (ALT),aspartate aminotransferase (AST) levels before and after treat-ment,and the incidence of adverse reactions in 2 groups observed. RESULTS:Short-term clinical efficacy in observation group was significantly higher than control group,with statistical significance(P<0.01). Before treatment,there were no significant dif-ferences in CEA,ALT and AST levels(P>0.05). After treatment,CEA,ALT and AST levels in 2 groups were significantly high-er than before,ALT and AST levels in observation group were significantly higher than control group,while CEA level in observa-tion group was lower than control group,with statistical significances(P<0.05). The incidences of bone marrow suppression,nau-sea,vomiting and fever in observation group were significantly lower than control group,with statistical significances (P<0.05). CONCLUSIONS:Paclitaxel combined with cisplatin and fluorouracil has good efficacy for gastric cancer with liver metastases via indwelling hepatic arterial catheter,while it exists liver dysfunction.

Cerebral arteriovenous malformation (AVM) is a common cerebrovascular disease in clinical practice. Although the treatment of AVMs has been w idely studied, the prognosis of the patients does not get significantly improvement. The main therapeutic purpose of AVMs is to reduce the risk of bleeding. This article review s the risk of bleeding and treatment modalities of AVMs.

Objective To investigate the incidence and risk factors of neck and back pain in pilots, aviation cadets and me-chanical maintenance personnel, with an aim to prevent the occurrence of the disorder among them.Methods A survey of 2001 cases of medical data was conducted, and then, the derived data concerning neck and back pain were compared and analyzed between pilots, aviation cadets and mechanical maintenance personnel.Results The incidence of neck and back pain in aviation cadets was 19.3%, and the incidence rates of the same disorder in pilots and mechanical maintenance personnel were 43.0%and 31.9%respectively.The incidence of neck and back pain in the aviation cadets flying fighters was 29%, and the incidence rates of the same disorder in the avia-tion cadets flying transports and helicopters were 44.1%and 37.4% respectively.Risk factors of neck and back pain among aviation cadets included age, flying time, smoking history, body mass index and lumbodorsal muscular exercise.Conclusion The incidence of neck and back pain in pilots was significantly higher than that in aviation cadets and mechanical maintenance personnel, and the inci-dence of the disorder was also relatively high in pilots flying transports.Flying time was the most important risk factor of neck and back pain, and the survey revealed that lumbodorsal muscular exercise was an effective protective factor.Close attention should be paid to the prevention of neck and back pain and counter measures should be developed for effective prevention of the disorder.