Rationale and Background:: Rationale and Background: Little to known about information about epidemiological data and rationale antibiotic use in respiratory infection among children in Laos. Therefore, we need to know the antibiotic use for children with respiratory infection for proper health planning. Objectives: : to determine the proportion of antibiotic use in Respiratory infection among children in Vientiane Capital. Laos PDR. Methodology: : Cross sectional descriptive study was carried out. 320 mothers or fathers of ill children were interviewed. Data were collected in the children hospital in May 2023. Descriptive statistics will be used for data analysis. Results: : 99 (30.3%) children were taken antibiotic prior to see doctors. 55.5% were taken amoxicillin. 43.1% and 38.1% were diagnosed for common cold and tonsillitis respectively. Doctors prescribe antibiotic for 156 48.8% and writing unclear suggestion to take medicine 54%, 275 cases (86%) and 45 cases (14%) were diagnosed as upper respiratory infection and lower respiratory infection respectively. Conclusion: Irrational antibiotics use was done in this study. Therefore, the rationale antibiotic therapy guideline for respiratory infection must be developed and implemented properly in order to avoid the socio-economic and public health negative effects.