YTHDF2 is a key m6A RNA modification"reader"that plays a crucial role in cell biological processes and tumor development.This review deeply explores the biological role of YTHDF2 and the advances in its application in tumors.The YTHDF2 structures are divided into mRNA procsomes and YTH domains,which recognize and bind m6A modified RNA molecules.It plays a biological role by promoting mRNA degradation,regu-lating cell signaling pathways and metabolism,and can regulate macrophage function and maintain an immunosup-pressive state in the tumor microenvironment.YTHDF2 has the potential to serve as diagnostic markers,therapeu-tic targets and prognostic evaluation biomarkers in different tumors,but currently relevant studies are insufficient in sample size,molecular mechanism and clinical application.In the future,research can be conducted on compre-hensive clinical research,in-depth analysis of molecular mechanisms,and research and development of optimized treatment strategies.

YTHDF2 is a key m6A RNA modification"reader"that plays a crucial role in cell biological processes and tumor development.This review deeply explores the biological role of YTHDF2 and the advances in its application in tumors.The YTHDF2 structures are divided into mRNA procsomes and YTH domains,which recognize and bind m6A modified RNA molecules.It plays a biological role by promoting mRNA degradation,regu-lating cell signaling pathways and metabolism,and can regulate macrophage function and maintain an immunosup-pressive state in the tumor microenvironment.YTHDF2 has the potential to serve as diagnostic markers,therapeu-tic targets and prognostic evaluation biomarkers in different tumors,but currently relevant studies are insufficient in sample size,molecular mechanism and clinical application.In the future,research can be conducted on compre-hensive clinical research,in-depth analysis of molecular mechanisms,and research and development of optimized treatment strategies.

Exosomes are extracellular vesicles derived from the bilayer membrane structure of the cell. It has been reported that the contents of some miRNA, mRNA, lncRNA and protein in exosomes are different between renal cell carcinoma patients and healthy controls, and the differences are statistically significant. These substances in renal cell carcinoma exosomes may be helpful for the diagnosis of renal cell carcinoma which may improve the early diagnosis rate of renal cancer. This article reviews the research progress of exosomes in the diagnosis of renal cell carcinoma.

Objective To explore the effect of head acupuncturing therapy combined with massaging key head acupoints on language and cognitive function in children with autism.Methods 60 children with autism who visited the Department of Pediatric Rehabilitation of our hospital from January 2021 to June 2022 were selected as subjects,who were then randomly divided into the conventional group treated with the conventional rehabilitation training and the combination group treated with head acupuncturing therapy combined with massaging the key acu-points,apart from conventional rehabilitation training 30 cases in each group.The cognitive function,developmental status,and parental quality of life before and after the treatment were compared between the two groups,and so were the language function and safety.Results There were no significant differences in the scores by Autism Behavior Checklist(ABC)and Childhood Autism Rating Scale(CARS),adaptability scores,language scores,and individual-social interaction scores between the conventional group and the combination group before the treatment(P>0.05).After the treatment,the scores by ABC and CARS were significantly decreased in both groups,and the scores of the combination group were significantly lower than those in the conventional group(P<0.05);The adaptability scores,language,individual-social interaction scores were significantly increased in both groups,and the scores of the combined group were significantly higher than those of the conventional group(P<0.05).The abnormal rates of symbolic expression,language comprehension,action-oriented subjects,and language development delay in the combined group were all significantly lower than those in the conventional group(P<0.05).There was no significant difference in the scores by the QL-Index between the conventional group and the combined group before the treatment(P>0.05),but after the treatment,the QL-Index scores of the conventional group and the combination group were increased,and the score of the combination group was significantly higher than that of the conventional group(P<0.05).The results of blood routine,urine routine,stool routine,liver function,and kidney function in both groups were not significantly abnormal.There was one case of mild swelling and pain at the acupunctured site in the combination group,which was improved without intervention.Conclusion Head acupuncturing therapy combined with massaging the key head acupoints can improve language function,cognitive function,and development of autis-tic children.In addition,it can enhance parental quality of life and have a high level of safety.

Objective:To provide references for disease diagnosis, treatment and aeromedical assessment by analyzing the characteristics of neurosurgical diseases in hospitalized military flying personnel.Methods:The case data and aeromedical assessment conclusions of 56 military flying personnel admitted to the Neurosurgery Department of Air Force Medical Center from 2010 to 2020 were collected. The diagnosis and treatment, as well as the flight post and aircraft type were retrospectively analyzed against the assessment conclusions.Results:The constituent ratio descending order of the neurosurgical diseases in the flying personnel was cerebrovascular disease (35.71%), central nervous system tumors (17.86%), sellar lesions (17.86%), arachnoid cysts (16.07%), traumatic brain injury (5.36%), scalp tumors (3.57%) and syringomyelia (3.57%) respectively. Among the 20 patients with cerebrovascular diseases, 5 received surgical treatment and other 15 received conservative treatment. In which 10 cases were qualified or restricted qualified, 9 cases were temporarily grounded, and 1 case was disqualified for flight. Among the 10 cases with central nervous system tumor, 5 received surgical treatment, 1 received radiotherapy and 4 received conservative treatment. In which 3 cases were qualified or restricted qualified, 3 cases were temporarily grounded and 4 cases were disqualified for flight. Among the 10 cases with saddle area lesions, 2 received surgical treatment, 3 received medical treatment and other 5 were observed by followed up. In which 8 cases were qualified or restricted qualified, 1 was temporarily grounded and 1 was disqualified for flight. Among the 9 cases with arachnoid cysts, 1 received surgical treatment and 8 received conservative treatment. In which 5 cases were qualified or restricted qualified, 1 was temporarily grounded and 3 were disqualified for flight. Among the other 7 cases, 5 received medical treatment or observed by follow-up, and 2 received surgical treatment. In which 6 cases were qualified for flight and 1 was temporarily grounded.Conclusions:Neurosurgical diseases should be paid more for flight safety due to quite a few restricted qualified, temperedly grounding or disqualified cases existed in the military flying personnel with such diseases.

Objective:To provide references for disease diagnosis, treatment and aeromedical assessment by analyzing the characteristics of neurosurgical diseases in hospitalized military flying personnel.Methods:The case data and aeromedical assessment conclusions of 56 military flying personnel admitted to the Neurosurgery Department of Air Force Medical Center from 2010 to 2020 were collected. The diagnosis and treatment, as well as the flight post and aircraft type were retrospectively analyzed against the assessment conclusions.Results:The constituent ratio descending order of the neurosurgical diseases in the flying personnel was cerebrovascular disease (35.71%), central nervous system tumors (17.86%), sellar lesions (17.86%), arachnoid cysts (16.07%), traumatic brain injury (5.36%), scalp tumors (3.57%) and syringomyelia (3.57%) respectively. Among the 20 patients with cerebrovascular diseases, 5 received surgical treatment and other 15 received conservative treatment. In which 10 cases were qualified or restricted qualified, 9 cases were temporarily grounded, and 1 case was disqualified for flight. Among the 10 cases with central nervous system tumor, 5 received surgical treatment, 1 received radiotherapy and 4 received conservative treatment. In which 3 cases were qualified or restricted qualified, 3 cases were temporarily grounded and 4 cases were disqualified for flight. Among the 10 cases with saddle area lesions, 2 received surgical treatment, 3 received medical treatment and other 5 were observed by followed up. In which 8 cases were qualified or restricted qualified, 1 was temporarily grounded and 1 was disqualified for flight. Among the 9 cases with arachnoid cysts, 1 received surgical treatment and 8 received conservative treatment. In which 5 cases were qualified or restricted qualified, 1 was temporarily grounded and 3 were disqualified for flight. Among the other 7 cases, 5 received medical treatment or observed by follow-up, and 2 received surgical treatment. In which 6 cases were qualified for flight and 1 was temporarily grounded.Conclusions:Neurosurgical diseases should be paid more for flight safety due to quite a few restricted qualified, temperedly grounding or disqualified cases existed in the military flying personnel with such diseases.

Objective:To investigate the disability status of the elderly in medical-nursing integrated pension institutions in Beijing and analyze its influencing factors.Methods:Using the convenient sampling method, a total of 359 elderly people from 5 medical-nursing integrated pension institutions in Beijing were selected from May to August 2019. General data and Elderly Disability Assessment Scale (EDAS) were used to evaluate the disability status of the included population, and univariate and multivariate analysis were conducted.Results:A total of 95.3% (342/359) of the elderly had disability. The single factor analysis result showed that male, low education level, a large number of chronic diseases, history of fall, history of smoking, history of drinking, widowed and elderly people living in nursing homes at their public expense were more disabled ( P<0.05) . Multivariate analysis showed that, history of falls, the number of chronic diseases greater than or equal to 3 and widowhood were the influencing factors for aggravated disability ( P<0.05) . Conclusions:In this survey, the rate of disability of the elderly in medical-nursing integrated pension institutions in Beijing is relatively high and the degree of disability is serious. The focus should be on the elderly who are male, with low educational level, smoking history, drinking history, falling history, comorbidities of the aged, the loss of spouse and those who bear the expenses of pension institutions at public expense.

Objective? To analyze the paper on traditional Chinese medicine (TCM) nursing in hypertension and understand the paper published and hot topics to explore the new trend of research in this field. Methods? Literatures were retrieved in China National Knowledge Infrastructure (CNKI) according to the search terms "hypertension" and "traditional Chinese medicine nursing" from building database to 27th June 2019. CiteSpace visualization software was used to visual analysis on the keywords, authors and published institutions of the literatures. Results? After eliminating duplication, a total of 308 literatures were included. Among those literatures, the number of published papers increased year by year, but total number was small. The number of papers co-authored and co-institution was small; there were only 17 authors and 16 institutions publishing papers more than two. The hot topics focused on researches on elderly hypertension, nursing for hypertension complications, TCM nursing for hypertension, effects of TCM nursing on quality of life;in recent years, the research hot topics was that TCM nursing guided hypertension patients' self-management. Conclusions? Self-management is an effective method for prevention and control of hypertension. With ageing populations,self-management is the prerequisite for being the healthy aged. Self-service nursing for hypertension guided by TCM nursing may become a trend.

Objective To explore investigate the feasibility of transoral removal of macrosis benign neoplasms in parapharyngeal space.Methods Sixteen patients with well-defined macrosis benign parapharyngeal space tumors treated by surgery from January 2005 to December 2012 were enrolled in this study.All patients were assessed by CT scan,MRI and CT angiography before surgery.Surgery for the tumors with complete peplos,locating at medial side of carotid and accessible from the oropharynx was completed with the assistance of endoscope,bipolar electrocoagulation or radiofrequency ablation system.Results All neoplasms were removed by transoral approach.Tracheotomy was performed in 4 cases.All patients were treated successfully with good postoperative recovery and no significant complications.Postoperative pathological examination showed there were 9 cases of pleomorphic adenoma,5 cases of neurilemmoma and 2 cases of neurofibroma.By the follows-up of 1-8 years (median 31 months),among 16 cases only one case of neurofibroma recurred.Conclusion The transoral removal of macrosis benign neoplasms in parapharyngeal space is safe,manimally invasive and feasible in selected cases,with a high local control rate and a low surgical complication rate.

Objective To analyze the clinical characteristics and the positions of asymptomatic cerebral infarction (ACI) in flying personnel,and to explore its risk factors.Methods The clinical data of flying personnel in our hospital who had been diagnosed as ACI by brain magnetic resonance imaging (MRI) were reviewed.The cases were divided into multiple group and single group by the number of infarctions.Statistical analysis was performed to assess the risk factors between two groups.Results Thirty-five cases of aircrew with ACI were analyzed,among which 28 cases (80.0％) had diagnosed risk factors of cerebrovascular diseases,and 12 (34.3％) had single risk,16 (45.7％) had more than one risk factors.The main risk factors included cerebral atherosclerosis,hypertension and smoking habit.We also found that the ischemic lesions were mainly located at the basal ganglia and subcortical white matter.Single group and multiple group respectively contained 14 and 21 cases.The average flight time was statistically significant between the two groups (P＜0.05).Conclusions The main risk factors of ACI in flying personnel including hypertension and cerebral atherosclerosis.The positions of ACI are mainly located at the subcortical white matter and basal ganglia.