1.Pharmacovigilance Signal Mining and Analysis of Ustekinumab versus Upadacitinib for Inflammatory Bowel Disease Based on the FAERS Database
Dong XIE ; Yu WANG ; Haojia LIN ; Qiuyue TU ; Hetong ZHANG ; Huizhen LI ; Qinghua YI ; Zhengxiang LI ; Hengjie YUAN ; Xiaocang CAO
Medical Journal of Peking Union Medical College Hospital 2025;16(6):1376-1383
To analyze potential adverse drug events(ADEs) associated with ustekinumab and upadacitinib in the treatment of inflammatory bowel disease(IBD) based on an international authoritative database, thereby providing evidence for clinical medication safety. Data were extracted from the Food and Drug Administration Adverse Event Reporting System(FAERS) database using OpenVigil 2.1. ADE reports were collected for ustekinumab(from Q3 2017 to Q1 2025) and upadacitinib(from Q3 2019 to Q1 2025), where each drug was identified as the primary suspected medication for IBD. Signal detection and statistical analysis were performed using the reporting odds ratio(ROR) and proportional reporting ratio(PRR) methods. A total of 3648 ADE reports for ustekinumab and 3812 for upadacitinib, with each as the primary suspected drug in IBD treatment, were retrieved. Using the ROR-PRR combined detection method, relevant ADE signals were identified. High-frequency ADEs associated with ustekinumab included hypersensitivity reactions, various infections, and brain fog, while those associated with upadacitinib included acne, flatulence, and herpes zoster. System organ class(SOC) analysis of positive signals indicated that both drugs commonly caused ADEs in categories such as Infections and infestations, Gastrointestinal disorders, Nervous system disorders, Skin and subcutaneous tissue disorders, and Respiratory, thoracic, and mediastinal disorders. Among these, Infections and infestations were the most frequent SOC, involving preferred terms such as Escherichia sepsis and Pneumococcal pneumonia. Ustekinumab and upadacitinib exhibit distinct safety profiles in the treatment of IBD. In addition to known ADEs described in the prescribing information, ustekinumab requires close monitoring for hypersensitivity reactions, opportunistic infections, and potential neurological risks. For upadacitinib, attention should be paid to risks of acne, herpes zoster, hypercholesterolemia, and thrombotic events. These findings provide important safety information to support individualized clinical decision-making in IBD management.
2.Clinical research progress of non-invasive neuromodulation in the treatment of bipolar disorder
Xudong ZHAO ; Hetong ZHOU ; Minmin WANG ; Xiaomei ZHANG ; Xin ZU ; Baohua SONG ; Xilong JIN ; Xinhua SHEN ; Mincai QIAN ; Shaohua HU
Chinese Journal of Psychiatry 2024;57(4):239-244
Bipolar disorder is a chronic mental disorder with a high rate of relapse, disability and suicide. Safe, effective and rapid onset non-invasive neuromodulation therapy technology is becoming a research hotspot in the treatment of bipolar disorder. In this paper, the latest clinical research progress of the main techniques in this field is summarized and reviewed, and its future prospects is also forecasted.
3.Interpretation of association standard of Operating Specifications for Repetitive Transcranial Magnetic Stimulation in Clinical Applications on Psychiatric Disorders
Shangda LI ; Shaohua HU ; Hetong ZHOU ; Jingkai CHEN ; Wentian DONG ; Hongxing WANG ; Jijun WANG ; Liwen TAN ; Zhongchun LIU ; Huaning WANG ; Yuqi CHENG ; Zhifen LIU ; Yumei WANG ; Wei DENG ; Xinhua SHEN ; Bo WEI ; Da LI ; Lishu YAO ; Yufeng ZANG ; Lin LU ; Manli HUANG
Chinese Journal of Psychiatry 2024;57(3):133-137
Repetitive transcranial magnetic stimulation (rTMS) has become an essential method in psychiatric disorders. However, many problems occurred in clinical application. This article interpreted the Association Standard T/CMEAS 011-2023'Operating Specifications for Repetitive Transcranial Magnetic Stimulation in Clinical Applications on Psychiatric Disorders′ released by the Chinese Medicine Education Association. The main content included a range of applications, normative references, terms and definitions, site specifications, equipment specifications, ability specifications of rTMS operators and rTMS process specifications.This article provided suggestions for clinical applications of rTMS on psychiatric disorders.
4.Interpretation of association standard of Operating Specifications for Repetitive Transcranial Magnetic Stimulation in Clinical Applications on Psychiatric Disorders
Shangda LI ; Shaohua HU ; Hetong ZHOU ; Jingkai CHEN ; Wentian DONG ; Hongxing WANG ; Jijun WANG ; Liwen TAN ; Zhongchun LIU ; Huaning WANG ; Yuqi CHENG ; Zhifen LIU ; Yumei WANG ; Wei DENG ; Xinhua SHEN ; Bo WEI ; Da LI ; Lishu YAO ; Yufeng ZANG ; Lin LU ; Manli HUANG
Chinese Journal of Psychiatry 2024;57(3):133-137
Repetitive transcranial magnetic stimulation (rTMS) has become an essential method in psychiatric disorders. However, many problems occurred in clinical application. This article interpreted the Association Standard T/CMEAS 011-2023'Operating Specifications for Repetitive Transcranial Magnetic Stimulation in Clinical Applications on Psychiatric Disorders′ released by the Chinese Medicine Education Association. The main content included a range of applications, normative references, terms and definitions, site specifications, equipment specifications, ability specifications of rTMS operators and rTMS process specifications.This article provided suggestions for clinical applications of rTMS on psychiatric disorders.
5.Clinical research progress of non-invasive neuromodulation in the treatment of bipolar disorder
Xudong ZHAO ; Hetong ZHOU ; Minmin WANG ; Xiaomei ZHANG ; Xin ZU ; Baohua SONG ; Xilong JIN ; Xinhua SHEN ; Mincai QIAN ; Shaohua HU
Chinese Journal of Psychiatry 2024;57(4):239-244
Bipolar disorder is a chronic mental disorder with a high rate of relapse, disability and suicide. Safe, effective and rapid onset non-invasive neuromodulation therapy technology is becoming a research hotspot in the treatment of bipolar disorder. In this paper, the latest clinical research progress of the main techniques in this field is summarized and reviewed, and its future prospects is also forecasted.
6.Occupational distribution and management strategies of occupational contact dermatitis
Huachun WANG ; Hetong LI ; Faming TIAN
Journal of Environmental and Occupational Medicine 2023;40(1):111-117
Occupational contact dermatitis (OCD) is an occupational inflammatory skin disease. According to its pathogenesis, it can be divided into irritant contact dermatitis and allergic contact dermatitis. This review introduced the high-risk occupations of OCD, its incidence, common irritants and allergens, and corresponding treatments. Agriculture workers, construction workers, production workers, hairdressers, and medical workers are high-risk occupations of OCD who should be paid attention to.
7.Relationship between transforming growth factor gene single nucleotide polymorphisms and susceptibility of lung cancer
Lu BAI ; Hong YU ; Hetong WANG ; Yuxia ZHAO
Chinese Journal of Postgraduates of Medicine 2016;39(4):292-295
Objective To investigate the association of transforming growth factor (TGF) gene rs1800469 (TGF1-509C/T) and rs1982073 (TGF1+869T/C) single nucleotide polymorphisms (SNP) with susceptibility of lung cancer. Methods The case group consisted of 193 histologically diagnosed lung cancer patients, and control group of 211 controls were selected from cancer-free patients at the same time. The single nucleotide polymorphisms of rs1800469 (TGF1-509C/T) and rs1982073(TGF1+869T/C) were analyzed by real-time fluorescent quantitative reverse transcription polymerase chain reaction method. The demographic characteristics, correlated risk factors of exposure and SNP between 2 groups were compared. Results The genotype distribution frequency of TGF1+869T/C and TGF1-509C/T in control group was accorded with Hardy-Weinberg law (P>0.05). The TT, TC and CC genotype distribution frequency in TGF1+869T/C in case group were 16.1%(31/193), 55.4%(107/193) and 28.5%(55/193), while these in control group were 22.3% (47/211), 50.2% (106/211) and 27.5% (58/211), and there were no statistical differences (P>0.05). The TT, TC and CC genotype distribution frequency in TGF1-509C/T in case group were 28.0%(54/193), 56.0%(108/193) and 16.1%(31/193), while these in control group were 27.0% (57/211), 51.2% (108/211) and 21.8% (46/211), and there were no statistical differences (P>0.05). The allele in rs1800469 (TGF1-509C/T) and rs1982073 (TGF1+869T/C) showed no association with lung cancer (P>0.05). Conclusions TGF gene SNP may not be associated with susceptibility to lung cancer in Han Chinese in North China.
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