Tooth eruption is a localised event whereby the signals for eruption for a given tooth are synthesised in the dental follicle of that tooth with a possible cross talk of signals coming from the adjacent stellate reticulum. The eruption process requires alveolar bone resorption that is primarily regulated by the dental follicle. This is reflected by the fact that failures of eruption often can be traced to either osteoclast deficiencies or to dental follicle abnormalities. Recent advances in application of molecular techniques to animal models allowed for better understanding of gene regulatory events involved in the physiology of tooth eruption. This article attempts to consolidate and organise the facts that offshoot from animal studies.
Tooth Eruption ; Dental Sac ; Molecular Biology

Objective: This study aimed to compare the predicted and achieved labiolingual inclinations of the maxillary central incisors in adult Class II division 2 malocclusions treated with clear aligners using Power Ridges® and composite attachments. Methods: This retrospective study included 24 patients (mean age, 26.5 ± 3.3 years). The patients had Class II division 2 malocclusion and were treated with non-extraction with Invisalign® clear aligners with either Power Ridges® or composite attachments to enhance the predictability of required change in labiolingual inclination for the maxillary central incisors.Before treatment, treatment prediction and final digital models were exported as stereolithography files and superimposed using the eModel 9.0 “Compare” software. The predicted and achieved labiolingual incisor inclinations were compared. Results: The mean accuracies of the achieved inclination of the central incisors were 68.3% in the Power Ridges® group and 71.6% in the attachments group. No statistically significant differences in predictability were found between the groups (P > 0.05). A low positive correlation was observed between the predicted inclination change and the average absolute difference between the predicted and achieved inclinations (r = 0.19). Conclusions Predicted labiolingual inclination is not fully achieved with clear aligners in both the Power Ridges® and attachment groups. Clinicians must take measures to counteract this limitation, specifically in Class II division 2 cases.

Background: Myasthenia gravis is an autoimmune disorder which affects the neuromuscular junction, resulting in muscle weakness and respiratory complications. Recurrent myasthenic crises may necessitate mechanical ventilation due to respiratory failure.Case Report: We present a 21-year-old female with myasthenia gravis who experienced recurrent myasthenic crises requiring mechanical ventilation. She underwent plasma exchange therapy and inspiratory muscle training (IMT) program to improve respiratory function. Gradual ventilator adjustments and a structured IMT protocol led to significant improvements in oxygenation and carbon dioxide elimination. The patient met the weaning criteria, including the PaO2/FiO2 ratio and rapid shallow breathing index, and was successfully extubated after 12 days of mechanical ventilation. Conclusion This case highlights the importance of a multidisciplinary approach in managing myasthenic crises and suggests that IMT may expedite weaning from mechanical ventilation.

NK cells belong to innate lymphoid cells and able to eliminate infected cells and tumor cells.NK cells play a valuable role in controlling viral infections. Also, they have the potential to shape the adaptive immunity via a unique crosstalk with the different immune cells. Murine models are important tools for delineating the immunological phenomena in viral infection.To decipher the immunological virus-host interactions, two major infection models are being investigated in mice regarding NK cell-mediated recognition: murine cytomegalovirus (MCMV) and lymphocytic choriomeningitis virus (LCMV). In this review, we recapitulate recent findings regarding the multifaceted role of NK cells in controlling LCMV and MCMV infections and outline the exquisite interplay between NK cells and other immune cells in these two settings. Considering that, infections with MCMV and LCMV recapitulates many physiopathological characteristics of human cytomegalovirus infection and chronic virus infections respectively, this study will extend our understanding of NK cells biology in interactions between the virus and its natural host.

Objective: This study aimed to compare the predicted and achieved labiolingual inclinations of the maxillary central incisors in adult Class II division 2 malocclusions treated with clear aligners using Power Ridges® and composite attachments. Methods: This retrospective study included 24 patients (mean age, 26.5 ± 3.3 years). The patients had Class II division 2 malocclusion and were treated with non-extraction with Invisalign® clear aligners with either Power Ridges® or composite attachments to enhance the predictability of required change in labiolingual inclination for the maxillary central incisors.Before treatment, treatment prediction and final digital models were exported as stereolithography files and superimposed using the eModel 9.0 “Compare” software. The predicted and achieved labiolingual incisor inclinations were compared. Results: The mean accuracies of the achieved inclination of the central incisors were 68.3% in the Power Ridges® group and 71.6% in the attachments group. No statistically significant differences in predictability were found between the groups (P > 0.05). A low positive correlation was observed between the predicted inclination change and the average absolute difference between the predicted and achieved inclinations (r = 0.19). Conclusions Predicted labiolingual inclination is not fully achieved with clear aligners in both the Power Ridges® and attachment groups. Clinicians must take measures to counteract this limitation, specifically in Class II division 2 cases.

Objective: This study aimed to compare the predicted and achieved labiolingual inclinations of the maxillary central incisors in adult Class II division 2 malocclusions treated with clear aligners using Power Ridges® and composite attachments. Methods: This retrospective study included 24 patients (mean age, 26.5 ± 3.3 years). The patients had Class II division 2 malocclusion and were treated with non-extraction with Invisalign® clear aligners with either Power Ridges® or composite attachments to enhance the predictability of required change in labiolingual inclination for the maxillary central incisors.Before treatment, treatment prediction and final digital models were exported as stereolithography files and superimposed using the eModel 9.0 “Compare” software. The predicted and achieved labiolingual incisor inclinations were compared. Results: The mean accuracies of the achieved inclination of the central incisors were 68.3% in the Power Ridges® group and 71.6% in the attachments group. No statistically significant differences in predictability were found between the groups (P > 0.05). A low positive correlation was observed between the predicted inclination change and the average absolute difference between the predicted and achieved inclinations (r = 0.19). Conclusions Predicted labiolingual inclination is not fully achieved with clear aligners in both the Power Ridges® and attachment groups. Clinicians must take measures to counteract this limitation, specifically in Class II division 2 cases.

Introduction: First permanent molars (FPMs) erupt early and their anatomy and location leave them susceptible to dental caries. This study aimed to retrospectively determine the prevalence, severity and pattern of dental caries of FPMs and investigate their relationship if any with demographics and medical health status of the partcipants. Methods: This was a retrospective cross-sectional study. A sample of the digital case notes and radiographs of children aged 5 to 12 years who attended the only postgraduate dental hospital in Dubai were accessed. The recorded data included the children’s demographic variables and the carious status of each FPM as recorded in the notes on the initial assessment. Descriptive and statistical analyses were conducted (P<0.05). Results: A total of 2984 FPMs were obtained from the digital records of 774 children. Their mean age was 8.07 (±2.23) years and only those that met the inclusion criteria were included in the study. The prevalence of dental caries and mean Decayed Missing Filled Surfaces of FPMs, were 42% and 0.3 (±0.04), respectively. The most prevalent decayed surface was the occlusal (29.2%), followed by mesial, buccal, palatal/ lingual, distal surfaces (24.2 %; 6.6 %; 3.1 %; 2.3 %) respectively. Children with medical problems and/or special needs had a significantly higher level of caries in the buccal surfaces (12.3%) (P=0.042). Conclusion: Caries of FPMs in a sample of Dubai children studied was prevalent, especially in those with special healthcare needs, thus indicating a necessity for targeted prevention and treatment focused on these keystone teeth.

NK cells belong to innate lymphoid cells and able to eliminate infected cells and tumor cells.NK cells play a valuable role in controlling viral infections. Also, they have the potential to shape the adaptive immunity via a unique crosstalk with the different immune cells. Murine models are important tools for delineating the immunological phenomena in viral infection.To decipher the immunological virus-host interactions, two major infection models are being investigated in mice regarding NK cell-mediated recognition: murine cytomegalovirus (MCMV) and lymphocytic choriomeningitis virus (LCMV). In this review, we recapitulate recent findings regarding the multifaceted role of NK cells in controlling LCMV and MCMV infections and outline the exquisite interplay between NK cells and other immune cells in these two settings. Considering that, infections with MCMV and LCMV recapitulates many physiopathological characteristics of human cytomegalovirus infection and chronic virus infections respectively, this study will extend our understanding of NK cells biology in interactions between the virus and its natural host.

Objective: This study aimed to compare the predicted and achieved labiolingual inclinations of the maxillary central incisors in adult Class II division 2 malocclusions treated with clear aligners using Power Ridges® and composite attachments. Methods: This retrospective study included 24 patients (mean age, 26.5 ± 3.3 years). The patients had Class II division 2 malocclusion and were treated with non-extraction with Invisalign® clear aligners with either Power Ridges® or composite attachments to enhance the predictability of required change in labiolingual inclination for the maxillary central incisors.Before treatment, treatment prediction and final digital models were exported as stereolithography files and superimposed using the eModel 9.0 “Compare” software. The predicted and achieved labiolingual incisor inclinations were compared. Results: The mean accuracies of the achieved inclination of the central incisors were 68.3% in the Power Ridges® group and 71.6% in the attachments group. No statistically significant differences in predictability were found between the groups (P > 0.05). A low positive correlation was observed between the predicted inclination change and the average absolute difference between the predicted and achieved inclinations (r = 0.19). Conclusions Predicted labiolingual inclination is not fully achieved with clear aligners in both the Power Ridges® and attachment groups. Clinicians must take measures to counteract this limitation, specifically in Class II division 2 cases.

Background: Myasthenia gravis is an autoimmune disorder which affects the neuromuscular junction, resulting in muscle weakness and respiratory complications. Recurrent myasthenic crises may necessitate mechanical ventilation due to respiratory failure.Case Report: We present a 21-year-old female with myasthenia gravis who experienced recurrent myasthenic crises requiring mechanical ventilation. She underwent plasma exchange therapy and inspiratory muscle training (IMT) program to improve respiratory function. Gradual ventilator adjustments and a structured IMT protocol led to significant improvements in oxygenation and carbon dioxide elimination. The patient met the weaning criteria, including the PaO2/FiO2 ratio and rapid shallow breathing index, and was successfully extubated after 12 days of mechanical ventilation. Conclusion This case highlights the importance of a multidisciplinary approach in managing myasthenic crises and suggests that IMT may expedite weaning from mechanical ventilation.