Objective To investigate the methodology,technical considerations,and precautions of transcatheter arterial emboliza-tion(TAE)using medical adhesive as the primary embolic agent for visceral artery aneurysm(VAA).Methods A total of 14 patients with VAA treated with medical adhesive-based TAE were retrospectively analyzed.Among the 14 patients,6 cases were hepatic artery pseudoaneurysms,4 cases were true gastroduodenal aneurysms,3 cases were gastroduodenal pseudoaneurysms,and 1 case was renal artery pseudoaneurysm.Among the 14 patients,medical adhesive alone was used in 12 cases,while the other 2 cases were employed medical adhesive combined with supplemental coil embolization.Follow-up assessments including abdominal computed tomography angiography(CTA)and laboratory tests were conducted at 3,6,and 12 months post-procedure.Results Technical success was achieved in all cases with mean procedure duration of(60.4±8.2)min and average hospital stay of(8.9±2.1)d.No recanalization,aneurysm enlargement,or non-target embolization were observed during follow-up.Conclusion Medical adhesive-based TAE demonstrates high technical success when performed by experienced interventionists,with low complication rate,low recurrence rate,and low pro-cedure-related mortality,representing a cost-effective preferred treatment for VAA.

Objective To investigate the methodology,technical considerations,and precautions of transcatheter arterial emboliza-tion(TAE)using medical adhesive as the primary embolic agent for visceral artery aneurysm(VAA).Methods A total of 14 patients with VAA treated with medical adhesive-based TAE were retrospectively analyzed.Among the 14 patients,6 cases were hepatic artery pseudoaneurysms,4 cases were true gastroduodenal aneurysms,3 cases were gastroduodenal pseudoaneurysms,and 1 case was renal artery pseudoaneurysm.Among the 14 patients,medical adhesive alone was used in 12 cases,while the other 2 cases were employed medical adhesive combined with supplemental coil embolization.Follow-up assessments including abdominal computed tomography angiography(CTA)and laboratory tests were conducted at 3,6,and 12 months post-procedure.Results Technical success was achieved in all cases with mean procedure duration of(60.4±8.2)min and average hospital stay of(8.9±2.1)d.No recanalization,aneurysm enlargement,or non-target embolization were observed during follow-up.Conclusion Medical adhesive-based TAE demonstrates high technical success when performed by experienced interventionists,with low complication rate,low recurrence rate,and low pro-cedure-related mortality,representing a cost-effective preferred treatment for VAA.

Objective:To study the application of "experiential training on death education" in teaching nursing interns in the oncology department, and to explore a novel method of death education for nursing interns.Methods:From September 2019 to September 2023, a total of 120 nursing students who interned in the Department of Oncology, Nuclear Industry 416 Hospital were assigned to the control group (53 students) and the study group (67 students) based on their enrollment time. The control group received traditional theoretical teaching and experience in caring for terminally ill patients, while the study group received experiential training on death education. The Chinese death attitude profile-revised (DAP-R), coping with death scale (CDS), course satisfaction, and learning outcomes were observed after 3-month internship. A data analysis was conducted using SPSS 26.0. The differences between two groups were compared using the independent samples t-test. The differences before and after education in the same group were compared using paired t-test. The comparison of categorical data between groups was performed using the chi-square test, while ranked data were compared using the rank-sum test. Results:There were no significant differences in the DAP-R scores between the two groups before education ( P>0.05). The scores of five dimensions of DAP-R were significantly higher in the study group than in the control group after education [fear of death: (22.11±5.38) points vs. (17.14±5.23) points, P<0.05; death evasion: (14.83±4.07) points vs. (12.31±4.15) points, P<0.05; neutral acceptance: (19.95±4.44) points vs. (22.31±5.14) points, P<0.05; approaching acceptance: (32.16±6.93) points vs. (35.23±7.33) points, P<0.05; avoiding acceptance: (16.47±5.86) points vs. (18.94±5.09) points, P<0.05]. There were no significant differences in the six factors of CDS between the two groups before education ( P>0.05). The CDS scores were significantly higher in the study group than in the control group after education ( P<0.05). The scores of three dimensions (novelty of course content, course satisfaction, and self-engagement) were significantly higher in the study group than in the control group after education ( P<0.05). The scores of improvement of empathy [(2.44±0.55) points vs. (3.16±0.50) points], attention to spiritual issues [(2.61±0.49) points vs. (3.11±0.52) points], improvement of communication skills [(3.10±0.51) points vs. (4.23±0.47) points], and correct values of life [(2.29±0.44) points vs. (3.37±0.55) points] were significantly higher in the study group than in the control group after education ( P<0.05). Conclusions:Experiential training on death education can increase the experience of students, improve their attitude towards death and ability to cope with death, and enhance their initiative and enthusiasm for learning.

Objective:To study the application of "experiential training on death education" in teaching nursing interns in the oncology department, and to explore a novel method of death education for nursing interns.Methods:From September 2019 to September 2023, a total of 120 nursing students who interned in the Department of Oncology, Nuclear Industry 416 Hospital were assigned to the control group (53 students) and the study group (67 students) based on their enrollment time. The control group received traditional theoretical teaching and experience in caring for terminally ill patients, while the study group received experiential training on death education. The Chinese death attitude profile-revised (DAP-R), coping with death scale (CDS), course satisfaction, and learning outcomes were observed after 3-month internship. A data analysis was conducted using SPSS 26.0. The differences between two groups were compared using the independent samples t-test. The differences before and after education in the same group were compared using paired t-test. The comparison of categorical data between groups was performed using the chi-square test, while ranked data were compared using the rank-sum test. Results:There were no significant differences in the DAP-R scores between the two groups before education ( P>0.05). The scores of five dimensions of DAP-R were significantly higher in the study group than in the control group after education [fear of death: (22.11±5.38) points vs. (17.14±5.23) points, P<0.05; death evasion: (14.83±4.07) points vs. (12.31±4.15) points, P<0.05; neutral acceptance: (19.95±4.44) points vs. (22.31±5.14) points, P<0.05; approaching acceptance: (32.16±6.93) points vs. (35.23±7.33) points, P<0.05; avoiding acceptance: (16.47±5.86) points vs. (18.94±5.09) points, P<0.05]. There were no significant differences in the six factors of CDS between the two groups before education ( P>0.05). The CDS scores were significantly higher in the study group than in the control group after education ( P<0.05). The scores of three dimensions (novelty of course content, course satisfaction, and self-engagement) were significantly higher in the study group than in the control group after education ( P<0.05). The scores of improvement of empathy [(2.44±0.55) points vs. (3.16±0.50) points], attention to spiritual issues [(2.61±0.49) points vs. (3.11±0.52) points], improvement of communication skills [(3.10±0.51) points vs. (4.23±0.47) points], and correct values of life [(2.29±0.44) points vs. (3.37±0.55) points] were significantly higher in the study group than in the control group after education ( P<0.05). Conclusions:Experiential training on death education can increase the experience of students, improve their attitude towards death and ability to cope with death, and enhance their initiative and enthusiasm for learning.

OBJECTIVE To establish the specific chromatogram of Qianghuo Shengshi Tang(QHSS) reference sample, clarify the key quality attributes of QHSS, providing reference for the quality evaluation of QHSS reference sample. METHODS The SilGreen C18 column(4.6 mm×250 mm, 5 μm) was used. The mobile phase consisted acetonitrile and 0.2% formic acid aqueous solution. The detection wavelength was 328 nm. Established an HPLC characteristic spectrum analysis method for the reference sample of QHSS. A variety of chromatographic columns and different instruments were applied to investigate the adaptability of the system. HPLC-LTQ-Orbitrap MS was used to identify the specific peaks of the QHSS reference samples in positive ion mode. RESULTS There were 14 peaks in the specific chromatogram, which belonged to Notopterygii Rhizoma Et Radix, Angelicae Pubescentis Radix, Ligustici Rhizoma Et Radix, Chuanxiong Rhizome, Viticis Fructus, respectively. Ferulic acid(peak 3) was reference peak. A total of 22 compounds were identified by mass spectrometry, including coumarin and flavonoids. CONCLUSION The established specific chromatogram method of QHSS is simple, stable and reproducible. The material basis of QHSS reference sample is basically determined, providing a reference for the development and quality control of QHSS.

Objective To provide a reference for the selection of frailty assessment tools for stroke patients by conducting a literature review of existing frailty assessment tools for stroke patients. Methods Systematic searches were conducted in PubMed, Web of Science, EMbase, SinoMed, Wanfang, VIP, and China National Knowledge Infrastructure(CNKI) databases from their inception to May 2023. The literature that met the research purpose and question were screened, and the basic information of each article, including the first author, publication year, country of publication, type of research design, name of the assessment tool, dimensions of scale, the number of items, and assessment time, was extracted. Results A total of 1, 729 articles were retrieved in this study. After multiple screenings, 22 articles (including 8 frailty assessment tools) were ultimately included. The analysis results showed that the evaluation indicators, evaluation time, and evaluation methods of the 8 frailty assessment tools were different and had their own advantages and disadvantages. Among them, the frailty index was the most commonly used frailty assessment tool for stroke patients. The selection of effective frailty assessment tools for stroke patients is essential for strengthening prestroke risk stratification and improving poststroke outcomes. Conclusion There are significant differences among different frailty assessment tools, and existing assessment tools have limitations in measuring frailty in stroke patients. Comprehensive assessments should be conducted in combination with clinicians' experience and judgment. New frailty assessment tools are needed in future research to better guide the rehabilitation treatment and management of stroke patients.

Objective:To develop and evaluate a rapid and sensitive point-of-care chemiluminescent assay(POC-CLIA)for β-human chorionic gonadotropin(β-HCG).Methods:POC-CLIA was constructed based on alkaline phosphatase(Alp)-AMPPD lumi-nescence system and magnetic particles(Mps)carrier.Performance of POC-CLIA,including sensitivity,precision,accuracy,linear dilution,specificity,stability,hook effect and clinical application were evaluated.Results:Detection limit of β-HCG was 0.71 mU/ml,linear detection range was 0.710～1.092×104 mU/ml,and was no hook effect up to 1.7×105 mU/ml.Intra and inter batch coefficients of variation were less than 10％,and could be stored stably at 37℃ for 10 days.Accuracy deviation was within±10％,so results were reliable.There was no cross-reactivity between interfering substances and anti-β-HCG antibdies.For detecting β-HCG in 100 clinical serum samples,results were highly correlated with those that were tested by clinical standard methods(R2=0.997 0).Turnaround time for single sample was less than 15 min and throughput could reach 200 T/h.Conclusion:This method is adequate that can be widely used in grassroots communities to help large-scale screening of pregnancy and related diseases.

Objective To explore the clinical features and prognostic factors of gastric cancer patients liver metastasis.Methods Data from 7055 patients with gastric cancer were retrieved from Surveillance,Epidemiology and End Results(SEER)database between 2010 and 2015.The patients were divided into the liver metastases group(901 cases)and the non-liver metastases group(6154 cases)according to whether liver metastasis occurred.Univariate and multivariate Cox regression were used to analyze the prognostic risk factors,and the Kaplan-Meier method was used for survival analysis.Results There was a significant difference in age,gender,race,T stage,N stage,primary surgery,radiotherapy and tumor size between the two groups(P<0.05),and the median survival time of patients in the liver metastases group was 6 months,non-liver metastases group was 25 months.Cox regression analysis showed that age(P=0.009),tumor grade(P<0.001),surgery(P<0.001)and chemotherapy(P<0.001)were the main factors affecting the prognosis of gastric cancer with liver metastases.Conclusion Age,tumor grade,surgery and chemotherapy were the prognostic risk factors for gastric cancer with liver metastases.A nomogram based on age,tumor grade,surgery and chemotherapy has a good survival prediction significance for gastric cancer with liver metastases.

Objective To explore the clinical features and risk factors of preoperative anemia in patients with gastric cancer.Methods The clinical data of 218gastric cancer patients who received gastric cancer surgery in the Second Affiliated Hospital of Nanjing Medical University from January 2015 to December 2018 were retrospectively analyzed.Patients were divided into the anemia group(n = 84)and non-anemia group(n =134)based on hemoglobin levels.The gender,age,hypertension,diabetes,body mass index(BMI),carcinoembryonic antigen(CEA),cancer antigen 199(CA199),cancer antigen 724(CA724),tumor location,tumor size,clinical stage and lymph node metastasis were collected.The Logistic regression analysis was performed to analyze the risk factors of preoperative anemia in patients with gastric cancer.Results Among 218 patients with gastric cancer,the incidence of preoperative anemia was 38.53%,including 51 cases(60.7%)of mild anemia and 50 cases(59.5%)of normocytic anemia.There were no statistically signifi-cant differences in BMI,hypertension,diabetes,CEA,CA199,CA724,tumor location,and lymph node metastasis between the two groups(P>0.05),while there were statistically significant differences in the terms of gender,age,tumor size,and clinical stage be-tween the two groups(P<0.05).Multivariate Logistic regression analysis showed that gender(P = 0.002),age(P = 0.023),tumor size(P =0.001),and clinical stage(P =0.003)were independent risk factors for preoperative anemia in patients with gastric cancer.Conclusion Gender,age,tumor size and clinical stage are independent risk factors for preoperative anemia in patients with gastric canc-er,which is helpful for clinicians to take some intervention strategies for patients.