Objective To explore the relationship of the preoperative serum alanine aminotransferase(ALT)/aspartate aminotransferase(AST)ratio and imaging features to the prognosis of patients with hepatocellular carcinoma(HCC)after receiving transarterial chemoembolization(TACE),and to develop a nomogram model used for predicting the patient's overall survival(OS).Methods A total of 211 patients,who were diagnosed as HCC and were treated with TACE as the initial therapy at the Guangci Branch of the First Affiliated Hospital of Soochow University of China between July 2016 and July 2020,were enrolled in this study.The patients were randomly divided into the modeling group(n=139)and validation group(n=72).The receiver operating characteristic(ROC)curve was used to determine the optimal cutoff value of AST/ALT ratio.The univariate and multivariate Cox regression analyses were conducted in the modeling group to screen out the independent predictors affecting HCC patient's OS and to establish a prognostic model.Harrell consistency index(C-index)was used to evaluate the predictive ability of the nomogram model for OS in HCC patients,and the calibration curves were plotted to assess the predictive accuracy of the nomogram model.Results No statistically significant difference in the baseline feature distribution existed between the modeling group and validation group(P＞0.05).The median OS of the modeling group and validation group was 28.5 months(95％CI:22.1-34.9)and 25.1 months(95％CI:19.2-29.0)respectively,the difference was not statistically significant(x2=1.395,P=0.322).The optimal cutoff value of AST/ALT ratio for predicting OS was 1.10,and the area under curve(AUC)value was 0.674(95％CI:0.604-0.753).The Cox regression analysis indicated that the tumor number(HR=2.080,95％CI=1.245-3.475,P=0.005),tumor capsule(HR=1.771,95％CI=1.128-2.780,P=0.013),irregular marginal enhancement(HR=1.884,95％CI=1.190-2.984,P=0.007),and AST/ALT ratio(HR=2.450,95％CI=1.506-3.987,P＜0.01)were the independent prognostic factors for HCC patients receiving TACE treatment.Based on the above variables,a nomogram model for predicting OS was established,and the C-index values in the modeling group and validation group were 0.733(95％CI:0.650-0.826)and 0.770(95％CI:0.688-0.862)respectively.The calibration curves showed that no significant deviations existed between the predictive curves of the prognostic model and the ideal reference curves for one-,2-and 3-year OS.Conclusion The nomogram model,which is established based on the tumor number,imaging features and preoperative AST/ALT ratio,has an excellent value in predicting the prognosis of HCC patients treated with TACE.

This article presents a case study of a patient who had Cronkhite-Canada syndrome in combination with an asymptomatic novel coronavirus infection. The patient exhibited clinical symptoms of loss of appetite, hair and nail loss, and skin pigmentation. Digestive endoscopy revealed widespread and varying-sized polypoid changes in the mucosa of the stomach, duodenum, and colon. During the course of the illness, the patient tested positive for novel coronavirus nucleic acid. Treatment with moderate doses of prednisone resulted in the patient's hair regrowth and decreased skin hypopigmentation. The article provides a summary of the patient's diagnosis and treatment and a review of relevant literature, with the aim of enhancing clinicians' understanding of the disease.

Attracting the return of overseas medical consumption is not only a driving force for promoting supply side structural reform and improving industrial development quality and efficiency under the current"dual circulation"new development pattern,but also a powerful lever and new engine for promoting high-quality economic development.The main reasons for attracting the outflow of domestic medical consumption include the pursuit of advanced medical technology from abroad,the attraction of high-quality medical services from overseas,the huge price difference between domestic and foreign medical consumption,and domestic policies,laws,and institutional restrictions.Measures need to be taken to improve the level of medical technology,increase the supply of medical consumption,improve the quality of medical services,optimize the medical consumption environment,and reduce medical service costs to attract the return of overseas medical consumption.

Sanming launched substantial healthcare system reform in 2012,deeply recognizing that healthcare service price reform is an important healthcare system reform.Combined with the actual situation,Sanming systematically pushes forward the reform of medical service prices,dynamic adjustment and linkage reform,and explores the way that conforms to its own development,and has achieved better results.It primarily discusses the approaches,development outcomes,experiences,and insights of Sanming's healthcare service price reform.

Attracting the return of overseas medical consumption is not only a driving force for promoting supply side structural reform and improving industrial development quality and efficiency under the current"dual circulation"new development pattern,but also a powerful lever and new engine for promoting high-quality economic development.The main reasons for attracting the outflow of domestic medical consumption include the pursuit of advanced medical technology from abroad,the attraction of high-quality medical services from overseas,the huge price difference between domestic and foreign medical consumption,and domestic policies,laws,and institutional restrictions.Measures need to be taken to improve the level of medical technology,increase the supply of medical consumption,improve the quality of medical services,optimize the medical consumption environment,and reduce medical service costs to attract the return of overseas medical consumption.

Sanming launched substantial healthcare system reform in 2012,deeply recognizing that healthcare service price reform is an important healthcare system reform.Combined with the actual situation,Sanming systematically pushes forward the reform of medical service prices,dynamic adjustment and linkage reform,and explores the way that conforms to its own development,and has achieved better results.It primarily discusses the approaches,development outcomes,experiences,and insights of Sanming's healthcare service price reform.

Objective To investigate the effect of palmitoleic acid(POA)on pyroptosis of cardiomyocytes after hy-poxia/reoxygenation-induced injury in the human myocardium.Methods The experiment comprised a control group(Control,normal culture),a hypoxia/reoxygenation group(HR),a palmitoleic acid-treated group(HR+POA),and an anhydrous ethanol control group(HR+ET).Cardiomyocytes viability was assessed using CCK-8 assay,and the level of pyroptosis of cardiomyocytes was measured through the double staining with Hoechst33342/PI and LDH assay.ELISA was employed to detect the release of inflammatory factors IL-1 β and IL-18 in the cell culture supernatant.qRT-PCR and Western blot were utilized to determine the relative expression levels of mRNA and protein of pyroptosis-related genes,namely NLRP3,ASC,Caspase-1,GSDMD,IL-1 β and IL-18,respective-ly.Results CCK-8 assay showed that the survival of hypoxic/reoxygenated cardiomyocytes increased with the ad-dition of POA at concentrations ranging from 25 to 100 μmol/L,as compared to the HR group;a hypoxia/reoxy-genation model of cardiomyocyte was established.The expression of protein and mRNA increased in NLRP3,ASC,Cleaved caspase-1,GSDMD-N,IL-Iβ and IL-18 vs the control group(P＜0.05),the positive percentage of Ho-echst33342/PI staining in cardiomyocytes increased significantly(P＜0.05),the release of LDH,IL-Iβ,and IL-18 increased(P＜0.05).After intervention with 100 μmol/L POA,the protein and mRNA expression levels of NLRP3,ASC,Cleaved caspase-1,GSDMD-N,IL-Iβ,and IL-18 were significantly reduced in the HR+POA group vs HR+ET group(P＜0.05).The positive percentage of Hoechst33342/PI staining in cardiomyocytes de-creased significantly,and the levels of LDH,IL-Iβ and IL-18 significantly decreased(P＜0.05).Conclusion Palmitoleic acid may alleviate hypoxia/reoxygenation-induced injury of cardiomyocytes by inhibiting pyroptosis and inflammatory response after hypoxia/reoxygenation in human myocardium.

BACKGROUND:Tissue flossing is a new injury prevention tool and auxiliary exercise training strategy.Tissue flossing can increase joint range of motion,improve athletic performance,and relieve pain,and is increasingly widely used in the field of sports and rehabilitation. OBJECTIVE:To review the mechanism of tissue flossing and its application in sports and rehabilitation to provide a reference for follow-up research. METHODS:"Tissue flossing;compression tissue flossing;floss band;voodoo flossband;blood flow restriction;shearing of fascia;musculoskeletal rehabilitation;sport injury"were used as Chinese and English search terms to search on the databases of CNKI,WanFang,VIP,PubMed and EBSCO databases.Relevant articles from January 2000 to October 2022 were retrieved,and 86 articles were finally included according to inclusion and exclusion criteria. RESULTS AND CONCLUSION:Tissue flossing intervention can improve lower limb joint motion,improve sprint and jump performance,promote joint injury rehabilitation,and relieve pain subjectively.However,tissue flossing intervention did not improve the range of motion of the upper limb.There is still controversy on the acute enhancement of lower limb muscle strength.It has a good tendency to improve lower limb balance and stability and improve mental state,but more studies are needed to confirm.The possible mechanisms of tissue flossing intervention are mainly fascia shear,pain gating,blood flow restriction and reperfusion,and compression.Tissue flossing is a useful treatment option that can provide important contributions in the future in the areas of sports training,sports injury prevention and rehabilitation,but more long-term in-depth studies are needed.

Attracting the return of overseas medical consumption is not only a driving force for promoting supply side structural reform and improving industrial development quality and efficiency under the current"dual circulation"new development pattern,but also a powerful lever and new engine for promoting high-quality economic development.The main reasons for attracting the outflow of domestic medical consumption include the pursuit of advanced medical technology from abroad,the attraction of high-quality medical services from overseas,the huge price difference between domestic and foreign medical consumption,and domestic policies,laws,and institutional restrictions.Measures need to be taken to improve the level of medical technology,increase the supply of medical consumption,improve the quality of medical services,optimize the medical consumption environment,and reduce medical service costs to attract the return of overseas medical consumption.

Sanming launched substantial healthcare system reform in 2012,deeply recognizing that healthcare service price reform is an important healthcare system reform.Combined with the actual situation,Sanming systematically pushes forward the reform of medical service prices,dynamic adjustment and linkage reform,and explores the way that conforms to its own development,and has achieved better results.It primarily discusses the approaches,development outcomes,experiences,and insights of Sanming's healthcare service price reform.