Objective To identify potential serum metabolic biomarkers in colorectal cancer(CRC)patients using untargeted metabolomics and to evaluate their diagnostic and staging value.Methods Serum samples from 100 healthy controls and 100 CRC patients were analyzed by ultra-performance liquid chromatography-mass spectrometry(UPLC-MS).After data normalization,differential metabolites were screened using multivariate statistical analyses(PCA,OPLS-DA)and subjected to pathway enrichment analysis.Diagnostic performance was assessed via univari-ate and multivariate regression,while Mfuzz clustering was applied to analyze stage-related metabolites(Ⅰ-Ⅳ).Results A total of 432 metabolites were identified with 59 showing significant alterations.Starch and sucrose me-tabolism and glycerophospholipid metabolism pathways were significantly enriched.A three-metabolite panel(4,8-dimethylnonanoyl carnitine,9,13-dihydroxy-4-megastigmen-3-one 9-glucoside and C17 sphingosine-1-phosphate)achieved a diagnostic AUC of 0.907,while L-Carnitine and L-Norleucine showed an AUC of 0.776 in staging anal-ysis.Conclusions Specific serum metabolite panel exhibit high diagnostic accuracy,and dysregulated metabolic pathways are associated with CRC progression,suggesting their potential value as biomarkers.

Objective:To explore the relationships among psychological resilience,spiritual health,and illness uncertainty in cancer patients,and to analyze the mediating role of disease uncertainty.Methods:The cancer patients were selected by convenience sampling method from Feb 2024 to May 2024 in the Department of Oncology of a Grade Ⅲ-A general hospital in Wuhu City.Data were collected using a general information questionnaire,the Mishel Uncertainty in Illness Scale(MUIS),the Functional Assessment of Chronic Illness Therapy-Spiritual Well-being Scale(FACIT-SP-12,Chinese version),and the Connor-Davidson Resilience Scale(CD-RISC-10).Pearson correlation analysis was conducted to assess the relationships among psychological resilience,illness uncertainty,and spiritual health.The mediating effect of illness uncertainty was tested using Hayes'PROCESS Model 4 and the Bootstrap method.Results:The total scores of spiritual health,psychological resilience and illness uncertainty of cancer patients was(25.11±7.19),(24.36±6.75)and(67.75±13.06),respectively.The spiritual health was positively correlated with psychological resilience(r=0.415,P＜0.01)and negatively correlated with illness uncertainty(r=-0.398,P＜0.01).The psychological resilience was negatively correlated with illness uncertainty(r=-0.668,P＜0.01).Illness uncertainty partially mediated the relationship between psychological resilience and spiritual health,accounting for 35.29%of the total effect.Conclusions:The spiritual health of cancer patients is at a moderate level.Enhancing psychological resilience and reducing illness uncertainty can alleviate psychological burden and improve spiritual health,thereby promoting overall quality of life.

[Objective]To investigate the prevalence rate of chronic non-communicable diseases(NCDs)and the association with quality of life in middle-aged and elderly patients with HIV/AIDS.[Methods]This cross-sectional study surveyed 432 patients with HIV/AIDS(aged≥45 years)in the Infectious Disease Center in Guangzhou Eighth People's Hospital of Guangzhou Medical University,and 366 participants were included in the analysis after quality control.A questionnaire and the EuroQol 5-Dimensional 3-level version(EQ-5D-3L)were used to investigate NCDs and quality of life and Tobit regression model was used to estimate the association between chronic diseases and quality of life.[Results]Among the 366 participants,29(7.9%)had cardiovascular disease,45(12.3%)had hypertension,122(33.3%)had hyperglycemia,151(41.3%)had hyperlipidemia,7(1.9%)had cancer,17(4.6%)had chronic kidney disease,38(10.4%)had chronic liver disease,21(5.7%)had musculoskeletal disorders,and 253(69.1%)suffered from at least one type of chronic diseases.The median(lower and upper quartiles)of EQ-5D utility index was 1.000(0.964～1.000).Multivariate Tobit regression results of the total population showed that cancer[ba=-0.08,95%CI(-0.15,-0.01),P=0.036],chronic kidney disease[ba=-0.07,95%CI(-0.12,-0.02),P=0.006],musculoskeletal disease[ba=-0.09,95%CI(-0.13,-0.05),P<0.001],and≥3 types of chronic diseases[ba=-0.05,95%CI(-0.08,-0.01),P=0.013]were negatively correlated with EQ-5D utility index.The stratified analysis results of different CD4+T cell levels showed that hypertension[ba=-0.07,95%CI(-0.12,-0.02),P=0.007],chronic kidney disease[ba=-0.10,95%CI(-0.18,-0.03),P=0.006],musculoskeletal disease[ba=-0.15,95%CI(-0.22,-0.07),P<0.001]and≥3 types of chronic diseases[ba=-0.09,95%CI(-0.09,-0.01),P<0.001]were negatively correlated with EQ-5D utility index in the group with CD4≤500(cells/μL),whereas cancer[ba=-0.11,95%CI(-0.20,-0.01),P=0.031]was negatively correlated with EQ-5D utility index in the group with CD4＞500(cells/μL).[Conclusions]The prevalence rate of chronic non-communicable diseases in middle-aged and elderly patients with HIV/AIDS is relatively high.The classification of NCDs such as cancer or chronic kidney disease or other chronic diseases and the numbers of NCDs categories are negatively correlated with quality of life.However,this association varies among patients with HIV/AIDS of different CD4+T cell levels.It is suggested that we should try to prevent and identify NCDs at an early stage,strengthen linkages and integration of health services for AIDS and chronic NCDs,and jointly manage and control AIDS with chronic diseases to improve the quality of life among people living with HIV/AIDS.

Objective:To explore the relationships among psychological resilience,spiritual health,and illness uncertainty in cancer patients,and to analyze the mediating role of disease uncertainty.Methods:The cancer patients were selected by convenience sampling method from Feb 2024 to May 2024 in the Department of Oncology of a Grade Ⅲ-A general hospital in Wuhu City.Data were collected using a general information questionnaire,the Mishel Uncertainty in Illness Scale(MUIS),the Functional Assessment of Chronic Illness Therapy-Spiritual Well-being Scale(FACIT-SP-12,Chinese version),and the Connor-Davidson Resilience Scale(CD-RISC-10).Pearson correlation analysis was conducted to assess the relationships among psychological resilience,illness uncertainty,and spiritual health.The mediating effect of illness uncertainty was tested using Hayes'PROCESS Model 4 and the Bootstrap method.Results:The total scores of spiritual health,psychological resilience and illness uncertainty of cancer patients was(25.11±7.19),(24.36±6.75)and(67.75±13.06),respectively.The spiritual health was positively correlated with psychological resilience(r=0.415,P＜0.01)and negatively correlated with illness uncertainty(r=-0.398,P＜0.01).The psychological resilience was negatively correlated with illness uncertainty(r=-0.668,P＜0.01).Illness uncertainty partially mediated the relationship between psychological resilience and spiritual health,accounting for 35.29%of the total effect.Conclusions:The spiritual health of cancer patients is at a moderate level.Enhancing psychological resilience and reducing illness uncertainty can alleviate psychological burden and improve spiritual health,thereby promoting overall quality of life.

Notoginseng Radix et Rhizoma as a traditional Chinese herbal medicine has now been recognized and paid attention to by the pharmaceutical community.Modern phytochemical studies have shown that Panax notoginseng saponin is the main chemical compo-nent of Notoginseng Radix et Rhizoma.Modern pharmacological studies and clinical applications have revealed that it has anti-cancer,antioxidant and cardiovascular disease effects.In this study,we reviewed the research progress of the main chemical components and pharmacological effects of Notoginseng Radix et Rhizoma,with the aim of providing assistance for the clinical application and later stud-ies of Notoginseng Radix et Rhizoma.

ObjectiveTo construct rehabilitation competency framework (RCF) of the speciality of education and rehabilitation (SER-RCF) based on World Health Organization RCF, to innovate the curriculum system. MethodsThe competency for undergraduate level professionals in the speciality of education and rehabilitation were analyzed to develop curriculum using RCF theory and methodology. ResultsTalent training was a kind of competency-based and outcome-based education. SER-RCF integrated the competencies and activities in the areas of professionalism, practice, learning and development, management and leadership, and research required for professional work in education and rehabilitation around core values and beliefs. It also designed the training objectives of the speciality of education and rehabilitation: to be ethical and correct, to be physically and mentally healthy, to have a solid foundation, to be sustainable, to be co-operative and enjoyable, and to be reflective and enquiring. SER-RCF played a central role in developing the curriculum system of rehabilitation, education and psychology, and practice. ConclusionReshaping the undergraduate level curriculum system of education and rehabilitation based on RCF is not only the implementation of the construction concept of new medicine and new liberal arts, but also can effectively connect with the international standard of rehabilitation higher education.

Objective To investigate the characteristics of spatial orientation language comprehension and expression behavior ofchildren with autism. MethodsA three-ladder test was designed to test the comprehension and expression of "(go/come) to" sentences, including general subject-predicate sentences, conjunctive-predicate sentences with displacement purposes, and conjunctive-predicate sentences with displacement modes. March to June, 2022, the test was conducted on 17 children with autism from a special education school and 17 healthy children matched the scores of Peabody Picture Vocabulary Test-Chinese revised from a kindergarten. The typical errors were analyzed for children with autism. ResultsThe main effects of sentence ladders (F > 3.718, P < 0.05) and children groups (F > 8.782, P < 0.001) were significant on comprehension and expression of sentences, while the performance was poor for the complex sentences and for the children with autism. The common types of errors in expression were missing components, mixed sentences, autonomous sentences, inaccurate wording, inconsistent content, blending errors and non-response. The numbers and the distribution of error types were quite different from the children with autism to the healthy children. ConclusionChildren with autism are more difficult to understand and express "(go/come) to" sentences, mainly manifested in a higher error frequency and more kinds of error.

Objective:To explore the status quo and influencing factors of nursing staff's nursing informatics competencies and provide reference for the relevant departments of the hospital and nursing managers to cultivate their informatics competencies.Methods:In this cross-sectional study, from July 31 to August 12, 2019, totally 982 nurses from Peking University First Hospital were selected by convenient sampling and investigated with the General Informatics Questionnaire and Nursing Informatics Competency Scale. Multiple linear regression analysis was used to analyze the influencing factors of nursing informatics competencies. A total of 982 questionnaires were distributed in this study, and 982 valid questionnaires were recovered, with an effective recovery rate of 100%.Results:The total score of nursing informatics competencies of the 982 nurses was (125.61±22.79) , including (45.70±9.74) for informatics management ability, (31.83±6.08) for computer operation ability, (20.16±4.07) for computer software management ability, (15.54±3.23) for nursing informatics awareness, and (12.37±2.49) for nursing informatics operation ability. The multiple linear regression analysis showed that age, education, department and whether they had received informatics-related training were the main factors affecting their nursing informatics competencies ( P<0.05) . Conclusions:The nursing informatics competencies of the nursing staff of Peking University First Hospital is satisfactory. Age, education, department and whether they have received informatics-related training may affect their nursing informatics competencies. It is suggested that hospital managers and relevant departments should provide more individualized training for personnel of different age groups, different educational backgrounds and different departments.

Objective:To study the hypocalcemia in patients with inflammatory bowel disease (IBD) and its risk factors.Methods:Clinical data of 72 patients with IBD who were admitted to the Second Affiliated Hospital of Xi′an Jiaotong University from December 2017 to December 2019 were analyzed respectively, including 59 patients with ulcerative colitis (UC) and 13 with Crohn′s disease (CD) . The patients were divided into the hypocalcemia group ( n = 29) and the normal blood calcium group ( n = 43) . Univariate analysis was conducted on the influencing factors of the hypocalcemia, and the factors with statistical significance were included in the Logistic regression model for multivariate analysis. The factors were analyzed by receiver operator characteristic (ROC) curve and the area under curve (AUC) was calculated. Results:The univariate analysis showed that prealbumin, total protein, albumin, hemoglobin, total cholesterol, serum sodium, serum phosphorus, disease activity index (DAI) , Crohn′s disease activity index (CDAI) and sunshine duration ≤2 h/d were the influencing factors of hypocalcemia in IBD patients (all P<0.05) . Multivariate Logistic regression analysis showed that albumin ( OR = 3.421, 95% CI: 1.301-4.134, P = 0.008) , DAI ( OR = 3.096, 95% CI: 1.901-8.907, P = 0.024) , CDAI ( OR = 2.248, 95% CI: 1.211-7.352, P = 0.033) and sunshine duration ≤2 h/d ( OR = 1.442, 95% CI: 1.334-5.881, P = 0.007) were the independent risk factors for hypocalcemia in IBD patients. The AUC of the above four indexes were all >0.7. Conclusions:The patients with IBD are prone to hypocalcemia. If IBD patients have lower albumin, higher DAI or CDAI, and sunshine duration ≤2 h/d, the risk of hypocalcemia will increase.

Objective:To study the hypocalcemia in patients with inflammatory bowel disease (IBD) and its risk factors.Methods:Clinical data of 72 patients with IBD who were admitted to the Second Affiliated Hospital of Xi′an Jiaotong University from December 2017 to December 2019 were analyzed respectively, including 59 patients with ulcerative colitis (UC) and 13 with Crohn′s disease (CD) . The patients were divided into the hypocalcemia group ( n = 29) and the normal blood calcium group ( n = 43) . Univariate analysis was conducted on the influencing factors of the hypocalcemia, and the factors with statistical significance were included in the Logistic regression model for multivariate analysis. The factors were analyzed by receiver operator characteristic (ROC) curve and the area under curve (AUC) was calculated. Results:The univariate analysis showed that prealbumin, total protein, albumin, hemoglobin, total cholesterol, serum sodium, serum phosphorus, disease activity index (DAI) , Crohn′s disease activity index (CDAI) and sunshine duration ≤2 h/d were the influencing factors of hypocalcemia in IBD patients (all P<0.05) . Multivariate Logistic regression analysis showed that albumin ( OR = 3.421, 95% CI: 1.301-4.134, P = 0.008) , DAI ( OR = 3.096, 95% CI: 1.901-8.907, P = 0.024) , CDAI ( OR = 2.248, 95% CI: 1.211-7.352, P = 0.033) and sunshine duration ≤2 h/d ( OR = 1.442, 95% CI: 1.334-5.881, P = 0.007) were the independent risk factors for hypocalcemia in IBD patients. The AUC of the above four indexes were all >0.7. Conclusions:The patients with IBD are prone to hypocalcemia. If IBD patients have lower albumin, higher DAI or CDAI, and sunshine duration ≤2 h/d, the risk of hypocalcemia will increase.